Tirosint-Sol: A Brand New Thyroid Medication (Should you give it a try?)

Tirosint-Sol: A Brand New Thyroid Medication (Should you give it a try?)

Tirosint-Sol is a new thyroid medication which was recently released in the United States to treat hypothyroidism. 

And it is now the 'cleanest' thyroid medication on the market today!

There are a great many benefits to this medication (1) that I want to explore with you in this article. 

I fear that the benefits of this new medication may be understated by doctors who don't understand that so many people have problems with thyroid medication absorption. 

So let this article be a guide to help you understand the issues with other thyroid medications and why Tirosint-Sol can be a great asset to many thyroid patients. 

Disclaimer: While I am writing about the benefits of Tirosint-Sol I have NO affiliation with the pharmaceutical company who produces or manufactures this medication. All of the opinions you see here are mine. All financial interests between doctors and pharmaceutical companies are made public and you can confirm that I have no affiliation with them in any way through public forms. I actually believe that this medication can provide a great benefit to many thyroid patients which is why I am sharing this information. 


What is Tirosint-Sol?

Put simply:

Tirosint-Sol is a new thyroid medication (2) which is designed to treat hypothyroidism and is also FDA approved to treat people with thyroid cancer who need a suppressed TSH. 

New thyroid medications can be confusing to people who are already taking thyroid medication. 

They see a 'new medication' and may think that we have made new advancements in thyroid medication technology. 

While that is partially true, it's probably not exactly what you think. 

Tirosint-Sol is really just an elaboration on a medication that already existed known as Tirosint. 

Tirosint should be differentiated from Tirosint-Sol, however, because they are different (more on that below)!

So, while the medication is new, the relative treatment has stayed the same. 

Tirosint-Sol is unique among thyroid medications not because it contains a new thyroid hormone but because of how it comes prepared and how you take it. 

You are probably used to taking medications which are either formulated in capsules or formulated in tablets. 

These tablets are necessary to help stabilize the medication, but they can also cause trouble for a number of patients (again, an elaboration on that very topic below!). 

Tirosint-Sol bypasses this problem because it comes in a liquid form. 

Yes, that's right, Tirosint-Sol is a liquid thyroid medication that can be swallowed or placed in a cup of water. 

The reason this is so important has to do with how many thyroid patients suffer from thyroid hormone malabsorption from things like medications they take (3), supplements they are using, low stomach acid (4), binders/fillers in existing thyroid medications, existing intestinal issues (5), and so on. 

Let's explore these topics in more detail to see if Tirosint-Sol is right for you.

Download my Free Resources:

Foods to Avoid if you have Thyroid Problems: 

I've found that these 10 foods cause the most problems for thyroid patients. Learn which foods you should absolutely be avoiding if you have thyroid disease of any type. 

The Complete List of Thyroid Lab Tests:

This list includes optimal ranges, normal ranges, and the complete list of tests you need to diagnose thyroid hypothyroidism correctly!

Download more free resources on this page

Inactive Ingredients and How they Impact your Thyroid

You're probably used to thinking about medication side effects before you take a medication. 

Thyroid medication is no exception, and you should absolutely be thinking about these effects before you start taking any medicine. 

But you need to understand what causes these side effects. 

You can get side effects from the active ingredients in the medication (this is the part of the medication which impacts your physiology) but you can also get them from the inactive ingredients in the medication (6) (these ingredients do not serve a physiologic purpose but they are there to stabilize your medicine and manipulate how it is absorbed). 

When it comes to thyroid medication, you really need to understand how these two things impact how you feel while taking a medication. 

Because the active ingredient in any thyroid medication (including Tirosint-Sol) is the exact same replica of the thyroid hormone that your body makes on its own, any reaction you get related to this part of the medication is DOSE-RELATED (7). 

The reason is simple:

Unless you were born without a thyroid, your body knows how to handle thyroid hormone. It knows how to eliminate it, it knows how to use it on your cells, etc.

But what it doesn't necessarily know how to use are the inactive ingredients. 

And these ingredients can cause issues which are unrelated to the active ingredient (the actual thyroid hormone). 

You are, therefore, much more likely to respond to these ingredients when you take thyroid medicine. 

And the way that you react to these ingredients can include a number of negative side effects and symptoms

Reactions to inactive ingredients may include:

  • Urticaria (hives)
  • Pruritis (itching of the skin)
  • Skin rash
  • Flushing
  • Angioedema (rapid swelling)
  • Abdominal pain, nausea, vomiting, diarrhea
  • Fever
  • Arthralgia (joint pain)
  • Wheezing

These are all potential symptoms that can occur if you do not react well to the inactive ingredients in medications!

Collectively they are known as hypersensitivity reactions. 

The good news is that these symptoms stem only from the inactive ingredients which means if you have them that they should go away once you stop taking the medication. 

It also means that you can typically get rid of them by switching to a medication (such as Tirosint-Sol) which does not contain them. 

These symptoms are severely underdiagnosed and it is my belief that these hypersensitivity reactions tend to occur more commonly in people with hypothyroidism and especially those with Hashimoto's thyroiditis.

These patients (including you if you fall into this category) tend to be more sensitive to all types of medications and ingredients!

And, as an aside, this is also why I typically recommend who have hypothyroidism eliminate all unnecessary exposure to chemicals and pesticides just to be on the safe side. 

One last point while we are on this topic:

There are no patients who are known to be sensitive to thyroxine which is the active ingredient in Tirosint-Sol and all other thyroid medications (except Cytomel/liothyronine), so if you are having a negative reaction it is either dose-related (meaning you are taking too much or too little) or you are reacting to the inactive ingredients/binders/fillers in the medication itself

Tirosint-Sol Ingredient List

As I mentioned previously, Tirosint-Sol is now the 'cleanest' thyroid medication on the market because it has the fewest inactive ingredients. 

You generally want a medication with fewer inactive ingredients because it means that you are much less likely to react negatively to those inactive ingredients. 

Active ingredient in Tirosint-Sol:

  • Thyroxine (This is the T4 thyroid hormone that your body produces naturally)

Inactive ingredients in Tirosint-Sol (8):

  • Water
  • Glycerin

This gives Tirosint-Sol a grand total of 3 ingredients (1 active and 2 inactive). 

The next closest medication is Tirosint which contains 4 total ingredients. 

This might not seem like a big deal until you realize how your body can react to all of the inactive ingredients that I mentioned above. 

And until you realize just how many inactive ingredients other medications have. 

Let's compare this to Synthroid to help give you a better picture:

Active ingredients in Synthroid:

  • Thyroxine (This is the T4 thyroid hormone that your body produces naturally)

Inactive ingredients in Synthroid (9):

inactive ingredients in synthroid
  • Acacia
  • Confectioner's sugar (contains corn starch)
  • Lactose monohydrate - Yes this is lactose which may cause reactions in those who have lactose intolerance!
  • Magnesium stearate
  • Povidone
  • Talc
  • Color additives by strength which may include any of the following: FD&C Yellow No. 6 Aluminum Lake, Red No. 40, Blue No. 2, Yellow No. 10, Red No. 27 and 30, Blue No. 1, 
color additives in each dose of synthroid

How its Dosed

Tirosint-Sol is unique among thyroid medications because it is not contained in a tablet or capsule. 

This means it does require some basic measurements to get your dose. 

When you pick up the prescription it is given to you in an ampule which contains a liquid of thyroid hormone suspension.  

Each liquid suspension contains a certain concentration per milliliter of fluid. 

Tirosint-Sol ampules and doses

You then obtain your target dose by either directly putting the ampule into your mouth or by diluting it in water. 

Each packet comes with 30 ampules which can be taken daily. 

You can see an image of what that looks like below:

Tirosint-Sol ampules

Let's use a real-world example to make it more clear:

Imagine you are taking 100mcg of Synthroid and you want to switch to Tirosint-Sol because you are experiencing hypersensitivity side effects. 

In this case, you would get a new prescription for 100mcg of Tirosint-Sol which would come in a yellow suspension. 

Each day you would swallow or put into your mouth 1 milliliter of this fluid. 

Each milliliter of fluid you consume equals the same 100mcg of thyroxine you were getting from your Synthroid. 

You are probably not used to using liquid medications as an adult, but they may be hugely beneficial to those who have the issues we are about to discuss!

Who should use Tirosint-Sol?

So, should you run out and switch your prescription to Tirosint-Sol after reading this article?

Not necessarily, but you should definitely consider it if you fit into any of the classifications below. 

These people tend to have issues with regular thyroid medication due to a myriad of issues which can limit how much thyroid medication they are absorbing from capsules or tablets. 

A list of people who should consider switching from their current thyroid medication to Tirosint-Sol include:

  • Those people with intestinal issues (this includes conditions such as Celiac disease, IBS, IBD, acid reflux, low stomach acid, etc.) - all of these conditions make absorbing your thyroid medication more difficult. 
  • People who have hypersensitivity symptoms when taking Synthroid or levothyroxine
  • People who are lactose intolerant (10). 
  • Those people who have trouble balancing their TSH and free T4/free T3 despite taking their medication faithfully each day. 
  • People who continue to have the symptoms of hypothyroidism (weight gain, fatigue, hair loss, etc.) despite taking their thyroid medication each day and having "normal" labs
  • People who have a schedule which doesn't allow for their thyroid medication to be taken on an empty stomach. 
  • People who take multiple other types of prescription medications (these medications can all potentially interfere with thyroid medication absorption)
  • People taking iron, calcium supplements (11), or chromium picolinate (12) (these supplements can bind to and inhibit the absorption of thyroid medication in your intestinal tract). 
  • People who find it difficult to take their thyroid medication on an empty stomach (due to side effects or schedule). 
  • People who are taking antacids, sucralfate,  or proton pump inhibitors (13) (these all lower stomach acid and may decrease how well your body can breakdown the inactive ingredients in medications like Synthroid and levothyroxine). 


Not every single person will react the same way to thyroid medication.

So even if you fall into the categories listed above doesn't mean you HAVE to switch medications. 

But it does mean you should seriously consider it, especially if you are feeling poorly and you (or your doctor) don't have a good explanation for it. 

Tirosint vs Tirosint-Sol

We won't spend too much time on this topic but I want to quickly discuss the difference between Tirosint and Tirosint-Sol because I foresee this being an issue. 

Tirosint is a thyroid medication which has been available for some time and contains very few inactive fillers and ingredients

It is different from Tirosint-Sol, however, because it comes in a GEL CAPSULE. 

It is also different because it has a few more inactive ingredients compared to Tirosint-Sol. 

natural thyroid supplements version 2

Tirosint-Sol, on the other hand, is a complete liquid which comes in ampules and which only contains water, glycerin, and Thyroxine making it the cleanest thyroid medication available. 

Tirosint should also be differentiated from Tirosint-Sol because it is quite expensive. 

A month supply of Tirosint in a gel capsule will run you over $100 per month if you pay the cash price. 

Tirosint does have coupons available which you can take advantage of, however, to help reduce this price. 

In the past, I would typically start people directly on Tirosint because of these inactive ingredients (and skip levothyroxine/Synthroid), but that recommendation may switch to Tirosint-Sol in the future. 

How Much Does it Cost and Where can I get it?

As you might imagine, new medications can be expensive. 

It's not easy to find pricing on Tirosint-Sol because it is so new, but I called around to get the price from a couple of pharmacies and I can report on that below. 

It looks like any pharmacy can order supplies for this particular medication, but it's specifically available to 3 select specialty pharmacies per their website. 

Specialty pharmacies which can get you Tirosint-Sol as soon as possible include:

You can have your doctor call directly to order it for you through the number listed above. 

When I spoke on the phone to the pharmacist I found that there is an introductory price of $35 per month with the use of a coupon which the manufacturer is giving to everyone. 

Their goal is to eventually increase the price of this medication, but you can take advantage of this low price for a limited time (I'm not sure how long it will be). 

So, at least for now, you should pay no more than $35 per month for Tirosint-Sol. 

This $35 per month cost is the worst case scenario (cash pay) and it's possible that your insurance may cover the majority of the cost (but this varies based on what type of insurance you have). 

You can also try to get your doctor to send the prescription to your local pharmacy and they can order it from the main supplier as well. 

I was also able to find another coupon online which allows you to get the medication for no more than $15 per month (cash price) with a maximum benefit up to $85. 

Either way, it seems very likely that you can get this medication for a reasonable price especially when compared to Tirosint which can run over $150 cash price for a 1 month supply. 

These prices make Tirosint-Sol more cost-effective than Tirosint and Levoxyl and some NDT medications. 


If Tirosint-Sol continues to remain cost-effective (and cheap) then I honestly believe it may be worth it for MANY thyroid patients (probably the majority) to switch to it. 

The reason is simple:

In order for thyroid hormone to work, it must get into your body and bloodstream. And I think the number of people who suffer from thyroid hormone malabsorption (for a variety of reasons) is grossly underestimated. 

If you can afford Tirosint-Sol and you have a provider who is willing to give it a try, then I would at least consider a trial of this new medication. 

If the price of this medication shoots up to an unreasonable amount over the coming months then I may retract my statement, but I believe a great many people can benefit from using it right now. 

Now I want to hear from you:

Are you taking thyroid medication like Synthroid, levothyroxine or Levoxyl?

Are these medications working for you?

Have you tried switching medications in the past?

Are you thinking about using Tirosint-Sol? Why or why not?

Leave your questions or comments below!

References (Click to Expand)

Tirosint-sol thyroid medication (1)
Dr. Westin Childs

Dr. Westin Childs is a Doctor of Osteopathic Medicine. He provides well-researched actionable information about hormone-related disorders and formulates supplements to treat these disorders. He is trained in Internal Medicine, Functional Medicine, and Integrative Medicine. His focus is on managing thyroid disorders, weight loss resistance, and other sex hormone imbalances. You can read more about his own personal journey here.

64 thoughts on “Tirosint-Sol: A Brand New Thyroid Medication (Should you give it a try?)”

  1. Thank you for this update. I noticed it contained T4 only. Are there any suggestions for those of us needing a T4/T3 combination?

    • hi Kathleen,

      Yes, it is synthetic. I don’t really like that term, however, because there is no “natural” thyroid medication. Even the natural thyroid medication is from animals and not from humans, so it’s only natural in the sense that it isn’t created in a lab.

  2. Hello, I take Synthroid and my prescription bottle says Levothyroxine underneath.
    Does that mean it wasn’t available?
    Also would you know if Tirosint-Sol is available in Canada?
    Thanks for your help.

    • Hi Ian,

      It sounds like you are on the generic for levothyroxine which is standard for most people. I’m not 100% sure if it’s available in Canada or not because different countries allow the use of different medications.

      You can always ask your doctor to see if they are willing to prescribe it to you, however.

  3. Thank you so much for this info! I’ve been taking Synthroid for 32 years. My TSH was high in recent blood work. I have a new PCP who is a DO. Could be an absorption issue due to drinking my morning coffee 30 minutes after taking my Synthroid instead of waiting an hour like I was doing. I’m going back to waiting an hour and will have a repeat blood draw in 6 weeks. I have Celiac, too, and am sensitive to chemicals and additives, etc.. I am excited about Tiring Sol! I plan to ask my new PCP about it in 6 weeks after I get my test results. I believe your email and this info is an answer to prayer!

    • Hi Vicki,

      Glad you found it helpful! And yes, coffee can definitely interfere with thyroid medication absorption. Several studies have shown this to be the case. Coffee can also suppress T3/T4 levels as well.

  4. Thank you so much for this information. I no longer have a thyroid (removed after thyroid cancer almost 20 years ago). I’m going to talk to my doc about switching. One question. Will this or any medication ‘normalize’ my TSH number? TSH results generally confuse me – it’s always “too low” on the labs but I don’t have a thyroid so I can’t see why it matters as long as the other numbers are in range. Thanks so much.

    • Hi Debbie,

      Yes, all thyroid medications will lower the TSH through feedback loops in the brain. Most endocrinologists use the TSH as a way to fine-tune your dose of medication. I don’t believe that this is the best method for finding the correct dose, but most people do it because it’s so “easy”.

  5. I did not do well on Thyroxine, many years trying different doses etc. Tried adding T3 as a combo, too hard having to multi dose…. now taking NDT THYROVANZ.
    I am in Australia, will Tirosint Sol be available here?

    • Hi Trish,

      I’m not sure, each country has its own set of bodies that determine if they will allow a new drug in. You can always call a local pharmacy and ask if they have any plans of getting it and they can give you more information.

  6. I’m going to my doctor on Thursday and I am going to tell her about this. I was on desiccated thyroid medicine for 3 months, for the first time ever, and my t4 surprisingly dropped 2 full points. Do you know why? I’m pretty disappointed in the medicine actually.

  7. I am pretty sure I have side affects from inactive ingredients in the Levothyroxine. I did however switch to the 50mcgs, take 1 and a half a day in the AM, as I read it doesn’t have an ingredient all the others have. I’m also on Liothyronine 5 m (1 twice a day). I take Dexilant as I have gerd. I feel like this Tirosint-Sol may benefit me because of low acid. I have always waited at least a half an hour to drink coffee after my dosage and a full hour for food, so this liquid thyroid will enable me to take whenever? Also, do you treat patients ever with JUST cytomel or is it always a combo of the tirosint or Levo and the liothyronine. That’s a question out of curiosity. My numbers did seem to be in range and I actually had my Levo dose lowered after taking cytomel WITH my Levo. Anyway, thanks in advance for your answer!! I soooo wish you were in Texas!!! Thanks Doc!

    • Hi Renee,

      You can theoretically take this and Tirosint (the original) with food and with coffee without any issue, but I still wouldn’t recommend it.

      And yes, you can take T3 medications without T4, but I generally don’t advise it for everyone.

  8. I tried to switch to tirosint. Dr lowered my dose because she said it could seem stronger since it was going straight into my system. I only took 25mcg of synthroid so we tired lowest dose of tirosint which is 13mcg. I normally take my med around 4am when I wake to use restroom so I continued that schedule. The first night I took it, about an hour later I woke up with almost a rush of adrenaline. So next night I tired again, same thing. I took it one more night and just couldn’t deal with that feeling. I went back to synthroid on 4th night. I’m super bummed it didn’t work for me. I also had my numbers check a few weeks later and my tsh went from 1.61 to 3.96 and my tpo went from 5 to 66! I have been wondering if maybe I was going into a Hashimotos flair and it was a Coincidence that it happened when I changed medication or if the lower dose did it?

    • Hi Christina,

      Yes, there are a number of factors that could have contributed to your symptoms when you took it. Also, you are probably referring to using Tirosint and not Tirosint-Sol which is what this article is about.

      Both are new, but Tirosint-Sol is newer.

  9. I am a type 1 diabetic and I have hashimotos. I took nature throid for 3 months and levothyroxine for 1 month and my blood sugars ran 300-500. I had to quit taking thyroid medicine. I would love to take Tirosint-Sol but will it raise my blood sugar?

  10. Thank you for the info on Tyrosint-Sol. I plan to ask my doctor about it. I was previously taking Nature-throid for hypothyroidism and did very well with it. Because it is no longer available, I switched to Armour thyroid several months ago. In just five months my TSH has gone from .647 to 0.18 with my T3 and T4 levels staying within normal range. I am experiencing symptoms of fatigue, joint pain, and very dry itchy skin. I would value your input.

  11. After having side effects to levothyroxine, my endo switched me to Tirosint – 7mcg an titrated up. TSH sill increased. After consulting with a Functional-Integrative group, a test revealed my body wasn’t able to convert T4 to T3. I am now taking Cytomel. How long does it take to feel side effects from this medication? I’m keeping a symptoms diary – noting side effects Day One. Is this considered “typical”? Thank you!

  12. Thank you, so much, Dr. Childs. I just picked up my prescription. Wondering if you might comment on the best time to take the tirosint sol.
    sincerely, Helen Hartley

  13. Doctor. I had my thyroid removed 16 years ago when I was 22 years old! From that day until January 24, 2019, I had been on Levothyroxine and felt awful! Finally found a doctor who added cytomel to my Levothyroxine with no results except feeling worse! So at the end of February, she allowed me to change to NP THYROID because WP and Nature throid isn’t available anywhere around right now, and I had waited for the Nature throid! The NP has caused a rash under my chin of large itchy bumps? Will they go away? Do you have an opinion on what I should try? I also have PCOS and diabetes type 2! Can I up the np thyroid? I’m currently taking 120mg the largest dose with tiredness! I also take daily adrenal support, d3 5000, b12 and b complex. Thank you so much!!

  14. I have recently switched from Synthroid to Levoxyl because of cost. I’m not feeling well and have most of the allergic side effects you listed in your article, most especially severe joint pain and wheezing. I had these side effects with Synthroid also, but not as severe.
    I had my thyroid removed 16 years ago due to cancer. Would you recommend tirisint – sol or tirosint for me?

  15. Thank you for all of the information. I’m on 137.5 mcg Levothyroxine. I have to stay in a hypo state in order to not have a screaming headache. My hair is extremely thin, and I have steadily gained weight since my total thyroidectomy in Oct 2016. I am asking my doctor for Tyrosint tomorrow morning. I’m excited to give the SOL a try, but my pharmacy said to give it a few months to get more out to the pharmacies. Hopefully this is a game changer for me! Thanks for all of the great information you provided.

  16. Extremely informative! Totally supports/validates all the research I’ve done in last 20 years. Now 70, I’ve been on Synthroid since I was 50 but needed it when I was 30. Of course my PCP thought I was just fat, forty, and female who needed to diet and exercise in spite of strong family history of Hashimotos. Never even had a doctor actually feel of my neck/thyroid gland until I was 50. Although I was fortunate to have an immediate, positive result from Synthroid recent issues make me think it’s time to change so I had already been considering Tirosint. So blessed to discover your site and stoked to try the Tirosint-Sol. Thank you!

  17. I have been on tirosint for 4 months, am experiencing a sore neck and shoulders. My doctor wants me to switch to Levoxyl at the same dose. Would the tirosint-sol be a better option for me?
    Thanks, kathy Conway

  18. I started taking Tirosint-Sol 137mcg about 2 weeks ago and I am have having terrible acid reflux and GERD symptoms. I don’t dilute the ampule in water but I do drink quite a bit of water after I swallow the dose. I usually go back to sleep after taking the medication. I can’t find anything in the package insert about staying upright for a determined amount of time after ingesting the medication. Nor can I find anything about acid reflux or GERD is a side effect of this medication. Is there anything that I should be doing differently to avoid these issues?

  19. I have been refusing to go on medication because I fear side effects and have a deep mistrust of the pharmaceutical industry. I tried NDT for a few months and did great until I started waking up with swollen lips every morning. Stopped taking it, and that stopped happening.

    I was considering Tirosint-Sol because I have so many sensitivities, but recent patient reviews (drugs.com) indicate that some patients were happy on Tirosint and suddenly started having all kinds of horrible problems. Then they learned that Tirosint has recently changed manufacturers (I think the owner is actually manufacturing it themselves rather than outsourcing it as they had been). This is incredibly discouraging to read. Is it really that hard for manufacturers to duplicate a formula? I have emailed the company to see what they can tell me about this. Will let you know what they say (although I’m not expecting a lot of helpful info from them). I think the reviews were about Tirosint, but I would assume that any inconsistency issues with Tirosint could also impact Tirosint Sol?

    Also, I just read Sheila’s comment above mine and would also love to hear your thoughts, as I have GERD too.

    Thanks so much for all you do, Dr. Childs!

  20. I am over 75 yrs. old. I have been exhausted all my life. Synthroid never helped and I have been taking Levothyroxine, 50 mcg, tablet for several years. One doctor told me, “your thyroid is dead.” Needless to say, I am exhausted. All side effects apply to me. Currently I am waiting to see an Endocrinologist for several nodules on my thyroid. The nodules were needle biopsied about 4 years ago and were benign. I know the nodules are bigger now because I find it harder to swallow food, my throat is sore and my voice is hoarse. My neck feels full and uncomfortable. So far, doctors are useless. Blood tests come back normal, in normal range, and that’s it. Medication stays the same and no further testing is ordered. When I was young and pregnant (twice) my thyroid dosage was raised and I felt like a million dollars. After babies were born, my dosage was lowered to previous strength. Then I was back to being exhausted. I plan to print your article and give it to the new doctors I will see in the near future. Thank you for posting your article, and because you did, I have a hope that I haven’t had for years.

  21. I am on Nature-throid 98mg daily. I have been taking Mag Oxide faithfully for months and after reading this I will immediately switch to citrate.
    My provider is not sure if I’m hypo or hyper thyroid cuz my labs are all over the place. I have had some mild weight gain, dry skin, constipation. I am still an active 65!
    What do you think of Nature-throid?

  22. I know this is an older blog, but I just wanted you to know that I just switched over to Tirosint-sol after first being on Armour, then Naturthroid and finally NP. (I was on synthroid for years before I began my journey with NDT). I did well on all the NDT’s until they each changed their formulas. After finding out that NP changed as well and many people had horrible symptoms along with hypo symptoms that came back, I switched to Thyrovanz. I began waking up each morning with many itchy welts and allergy medicines wouldn’t help. sigh…

    So, finding this information about Tirosint-Sol seemed timely. (I also have many gut issues that I suspect were from being severely under dosed and from all the formulation changes). So, today begins my last ditch effort in hopes that Tirosint-Sol will work for me and that they will continue to offer the coupons so that I can afford to take a medicine that is close to $500 for three months!

    I am very curious if others have used it (I understand it’s super new), and maybe had really good luck on it? I did read some reviews and was disheartened by what I saw, but am trying to give it time and hoping I settle into this. I really need to get my old life back.

    So, if anyone IS on Tirosint-sol and are doing well on it, please post and share so that I can have a bit of encouragement while I wait the 4-6 weeks to see if it works for me.

  23. I just started Tirosint Sol. I’ve always been on NDT. First WP thyroid then NP when WP became unavailable. I did so well. I lost a lot of weight and was living the best life. That all ended. NP did something to their medication and it makes me terribly sick. After searching hard I found WP. It too has changed and is worthless. I even tried compounded NDT and t3/t4. The capsules made me sick with the NDT and the t3 in the other felt like it was way too much. I have celiac and many sensitivities. I have taken Levothryoxine once before and it caused me severe shoulder wrist and finger pain. I also swelled. This was before I went gluten free or knew of my gluten sensitivity. I tried Tirosint capsules and it hurt my stomach for some reason. This is my last hope. I was on 30mg NDT and have taken 50mcg of Levothryoxine in the past. I started on 25mcg of Tirosint Sol. I hope this works for me. I have nothing else.

  24. My doctor recently gave me trials of tirosint sol. I have been taking it for just over a month with no issues. I have malabsorption issues due to having bariatric surgery, so we are hoping that my next round of labs will show a difference. My only concern is whether or not my insurance will cover it. I have to say that I was worried that the taste of the liquid would make me gag, but it actually doesn’t taste bad. I hate swallowing pills, so that alone is a win for me.

  25. Dr. Childs,

    Might some people have trouble with the glycerine in Tirosint and Tirosint-Sol? Do I understand correctly that it is often called glycerol and is a sugar alcohol? Sorbitol and mannitol give me headaches.


  26. I love your site,, which I came upon by accident. I am having trouble sleeping and wake every morning with tremors. My PCP sent me to a neurologist who said I don’t have a neurological problem, she thinks it’s from my new asthma inhalers, so I stopped Perforomist and continue taking Budesonide & Ventolin. After 6 months of these symptoms, I remembered getting my Tirosint 13 mcg from a different manufacturer, so could that be the reason for the tremors?

  27. I was on Tirosint but my body metabolizes very quickly and I was crashing in afternoon. My doctor switched me to a compounded T4/T3 with extra methocel (50%) but I’ve gained weight rapidly! I am hoping to go back to a tirosint amd compounded T3 and just do 2 doses to sustain me. ExoressScriots actually was great and covered tirosint for me for $4 due to absorption issues with every other med I’ve tried. But now my husbands insurance switched to OptumRx who I’m not impressed with!! They don’t want to cover it any longer so I may try the SOL if my dr allows since it’s cheaper with the coupon code.

  28. I just came across this article because I am having an absurdly hard time regulating on Armor (right now it’s back to 2.5 grains split into two doses) I was on Tirosint plus a compounded T3 for years before I had my fourth child. Ever since V has been born (she just turned two) I can’t regulate my Hashimoto’s it’s in constant flux. I am going to my doc tomorrow and had planned on begging for Tirosint and T3 but now maybe I’ll bring up Tirosint-Sol. Thank you.

  29. I only have half a thyroid. Had a cyst on right side so it was removed. I do not currently take meds but I know when my thyroid is out of whack. I have struggled with the weight gaining for the last 20 years. My results always come back in the “normal range”. Do you think this new medicine would helo me?

  30. Hi there,
    First, thank you for a very well explained video describing Tirosint.
    My endo diagnosed me with sub clinical hypothyroidism in early 2019. I first tried Armour thyroid30-60mg, my labs improved as she wanted me at an “optimal level.” However, the side effects were HORRIBLE! I started having heart palpitations, and experienced my first ever anxiety attack, no fun! She then put me on levothyroxine, that somewhat helped but then I started noticing major hair shedding. She then prescribed Synthyroid 50mcg, and I still have hair shedding. Finally, today (3/31/20), she wants me to try Tirosint 50mcg, I bought the medication which was $127, kind of pricey but I’ll pay anything just to stop this hair loss and start seeing the benefits of my thyroid medication.
    I plan to start this medication tomorrow, but had a little concerns and questions.
    1. I know i’m extremely sensitive to armour thyroid and stimulants. Will this medication cause any anxiety or heart palpitations or nervousness?
    2. Was I likely losing hair because of the “fillers” in my Synthroid medication?

    Thank you again for your help and guidance with this new drug! Any feedback is helpful!

  31. Hi, I could use some help to just figure out if this is something in my head or a realistic thing that could happen. My doctor also thinks it might be going through perimenopause and anxiety has been a part of that.

    Anyways, I’ve been on tirosint regular gel caps and I was on 50mcg. I did take a 75 gel cap the night before and didn’t feel anything and slept good. I was switched over to The Tirosint SOL at my request which is a liquid. I took the liquid last night and then I felt like for the next 3 hours I couldn’t sleep and my heart felt like it kept palpitating. I felt it as soon as I took the medication so I’m wondering if my anxiety kicked in or could a liquid medication really cause that.

    I will admit I went into the medication with anxiety.

    Now, my heart feels fine.

  32. Hi Dr. Childs,

    How would one go about converting from NDT to Tyrosint-Sol? I’m currently taking 113.5 mcg of NatureThroid plus 10 mcg of Liothyronine (divided into two 5mcg doses) daily. Would I keep my dose of Liothyronine the same and start with a low dose of Tyrosint-Sol to be safe?


    • I tried to take my usual dose when switching to Tirosint gel capsules 88mcg and it was too much. I started getting heart flutters, weepy, head numbness, and depression, and acid reflux. I went down to 75 mcg then started getting wrist and foot pain and body fatigue with the acid reflux.
      I haven’t tried the Sol solution so I can’t say but one can assume it may be stronger because it’s more absorbed so be prepared to move down some if you have those symptoms. I’m not a person with absorption issues, however and my T4 levels on levothyroxine were always a bit on the high side already.

  33. I gave Tirosint Gel capsules a try but suffered extreme acid reflux which caused burning, coughing and choking on two different doses. It resolved within two days of discontinuing. I don’t have this issue with pill forms.
    Do you think I could avoid this issue on Tirosint Sol? I also have the issue of one dose too strong and the other too low. This isn’t exactly a cheap medication to have to mix and match. How does a person handle this issue with a medication that you can’t split?


Leave a Comment

Item added to cart.
0 items - $0.00