Tirosint-Sol: Is it Really Better Than Other Thyroid Medications?

Tirosint-Sol: Is it Really Better Than Other Thyroid Medications?

Tirosint-Sol is a newer thyroid medication that was recently released in the United States to treat hypothyroidism. 

And it is now the ‘cleanest’ thyroid medication on the market today!

There are a great many benefits to this medication (1) that I want to explore with you in this article. 

I fear that the benefits of this new medication may be understated by doctors who don’t understand that so many people have problems with thyroid medication absorption. 

So let this article be a guide to help you understand the issues with other thyroid medications and why Tirosint-Sol can be a great asset to many thyroid patients. 

Disclaimer: While I am writing about the benefits of Tirosint-Sol I have NO affiliation with the pharmaceutical company that produces or manufactures this medication. All of the opinions you see here are mine. All financial interests between doctors and pharmaceutical companies are made public and you can confirm that I have no affiliation with them in any way through public forms. I actually believe that this medication can provide a great benefit to many thyroid patients which is why I am sharing this information. 

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What is Tirosint-Sol?

Put simply:

Tirosint-Sol is a new thyroid medication (2) that is designed to treat hypothyroidism and is also FDA-approved to treat people with thyroid cancer who need a suppressed TSH. 

New thyroid medications can be confusing to people who are already taking thyroid medication. 

They see a ‘new medication’ and may think that we have made new advancements in thyroid medication technology. 

While that is partially true, it’s probably not exactly what you think. 

Tirosint-Sol is really just an elaboration on a medication that already existed known as Tirosint. 

Tirosint should be differentiated from Tirosint-Sol, however, because they are different (more on that below)!

So, while the medication is new, the relative treatment has stayed the same. 

Tirosint-Sol is unique among thyroid medications not because it contains a new thyroid hormone but because of how it comes prepared and how you take it. 

You are probably used to taking medications that are either formulated in capsules or formulated in tablets. 

These tablets are necessary to help stabilize the medication, but they can also cause trouble for a number of patients (again, an elaboration on that very topic below!). 

Tirosint-Sol bypasses this problem because it comes in a liquid form. 

Yes, that’s right, Tirosint-Sol is a liquid thyroid medication that can be swallowed or placed in a cup of water. 

The reason this is so important has to do with how many thyroid patients suffer from thyroid hormone malabsorption from things like medications they take (3), supplements they are using, low stomach acid (4), binders/fillers in existing thyroid medications, existing intestinal issues (5), and so on. 

Let’s explore these topics in more detail to see if Tirosint-Sol is right for you.

Inactive Ingredients and How they Impact your Thyroid

You’re probably used to thinking about medication side effects before you take a medication. 

Thyroid medication is no exception, and you should absolutely be thinking about these effects before you start taking any medicine. 

But you need to understand what causes these side effects. 

You can get side effects from the active ingredients in the medication (this is the part of the medication that impacts your physiology) but you can also get them from the inactive ingredients in the medication (6) (these ingredients do not serve a physiologic purpose but they are there to stabilize your medicine and manipulate how it is absorbed). 

When it comes to thyroid medication, you really need to understand how these two things impact how you feel while taking a medication. 

Because the active ingredient in any thyroid medication (including Tirosint-Sol) is the exact same replica of the thyroid hormone that your body makes on its own, any reaction you get related to this part of the medication is DOSE-RELATED (7). 

The reason is simple:

Unless you were born without a thyroid, your body knows how to handle thyroid hormones. It knows how to eliminate it, it knows how to use it on your cells, etc.

But what it doesn’t necessarily know how to use are the inactive ingredients. 

And these ingredients can cause issues that are unrelated to the active ingredient (the actual thyroid hormone). 

You are, therefore, much more likely to respond to these ingredients when you take thyroid medicine. 

And the way that you react to these ingredients can include a number of negative side effects and symptoms

Reactions to inactive ingredients may include:

  • Urticaria (hives)
  • Pruritis (itching of the skin)
  • Skin rash
  • Flushing
  • Angioedema (rapid swelling)
  • Abdominal pain, nausea, vomiting, diarrhea
  • Fever
  • Arthralgia (joint pain)
  • Wheezing

These are all potential symptoms that can occur if you do not react well to the inactive ingredients in medications!

Collectively they are known as hypersensitivity reactions. 

The good news is that these symptoms stem only from the inactive ingredients which means if you have them that they should go away once you stop taking the medication. 

It also means that you can typically get rid of them by switching to a medication (such as Tirosint-Sol) that does not contain them. 

These symptoms are severely underdiagnosed and it is my belief that these hypersensitivity reactions tend to occur more commonly in people with hypothyroidism and especially those with Hashimoto’s thyroiditis.

These patients (including you if you fall into this category) tend to be more sensitive to all types of medications and ingredients!

And, as an aside, this is also why I typically recommend who have hypothyroidism eliminate all unnecessary exposure to chemicals and pesticides just to be on the safe side. 

One last point while we are on this topic:

There are no patients who are known to be sensitive to thyroxine which is the active ingredient in Tirosint-Sol and all other thyroid medications (except Cytomel/liothyronine), so if you are having a negative reaction it is either dose-related (meaning you are taking too much or too little) or you are reacting to the inactive ingredients/binders/fillers in the medication itself

Tirosint-Sol Ingredient List

As I mentioned previously, Tirosint-Sol is now the ‘cleanest’ thyroid medication on the market because it has the fewest inactive ingredients. 

You generally want a medication with fewer inactive ingredients because it means that you are much less likely to react negatively to those inactive ingredients. 

Active ingredient in Tirosint-Sol:

  • Thyroxine (This is the T4 thyroid hormone that your body produces naturally)

Inactive ingredients in Tirosint-Sol (8):

  • Water
  • Glycerin

This gives Tirosint-Sol a grand total of 3 ingredients (1 active and 2 inactive). 

The next closest medication is Tirosint which contains 4 total ingredients. 

This might not seem like a big deal until you realize how your body can react to all of the inactive ingredients that I mentioned above. 

And until you realize just how many inactive ingredients other medications have. 

Let’s compare this to Synthroid to help give you a better picture:

Active ingredients in Synthroid:

  • Thyroxine (This is the T4 thyroid hormone that your body produces naturally)

Inactive ingredients in Synthroid (9):

inactive ingredients in synthroid
  • Acacia
  • Confectioner’s sugar (contains corn starch)
  • Lactose monohydrate – Yes this is lactose which may cause reactions in those who have lactose intolerance!
  • Magnesium stearate
  • Povidone
  • Talc
  • Color additives vary by strength and may include any of the following: FD&C Yellow No. 6 Aluminum Lake, Red No. 40, Blue No. 2, Yellow No. 10, Red No. 27 and 30, Blue No. 1,
color additives in each dose of synthroid

How its Dosed

Tirosint-Sol is unique among thyroid medications because it is not contained in a tablet or capsule. 

This means it does require some basic measurements to get your dose. 

When you pick up the prescription it is given to you in an ampule that contains a liquid of thyroid hormone suspension.  

Each liquid suspension contains a certain concentration per milliliter of fluid. 

Tirosint-Sol ampules and doses

You then obtain your target dose by either directly putting the ampule into your mouth or by diluting it in water. 

Each packet comes with 30 ampules that can be taken daily. 

You can see an image of what that looks like below:

Tirosint-Sol ampules

Let’s use a real-world example to make it more clear:

Imagine you are taking 100mcg of Synthroid and you want to switch to Tirosint-Sol because you are experiencing hypersensitivity side effects. 

In this case, you would get a new prescription for 100mcg of Tirosint-Sol which would come in a yellow suspension. 

Each day you would swallow or put into your mouth 1 milliliter of this fluid. 

Each milliliter of fluid you consume equals the same 100mcg of thyroxine you were getting from your Synthroid. 

You are probably not used to using liquid medications as an adult, but they may be hugely beneficial to those who have the issues we are about to discuss!

Who should use Tirosint-Sol?

So, should you run out and switch your prescription to Tirosint-Sol after reading this article?

Not necessarily, but you should definitely consider it if you fit into any of the classifications below. 

These people tend to have issues with regular thyroid medication due to a myriad of issues that can limit how much thyroid medication they are absorbing from capsules or tablets. 

A list of people who should consider switching from their current thyroid medication to Tirosint-Sol include:

  • Those people with intestinal issues (this includes conditions such as Celiac disease, IBS, IBD, acid reflux, low stomach acid, etc.) – all of these conditions make absorbing your thyroid medication more difficult. 
  • People who have hypersensitivity symptoms when taking Synthroid or levothyroxine
  • People who are lactose intolerant (10). 
  • Those people who have trouble balancing their TSH and free T4/free T3 despite taking their medication faithfully each day. 
  • People who continue to have the symptoms of hypothyroidism (weight gain, fatigue, hair loss, etc.) despite taking their thyroid medication each day and having “normal” labs
  • People who have a schedule that doesn’t allow for their thyroid medication to be taken on an empty stomach. 
  • People who take multiple other types of prescription medications (these medications can all potentially interfere with thyroid medication absorption)
  • People taking iron, calcium supplements (11), or chromium picolinate (12) (these supplements can bind to and inhibit the absorption of thyroid medication in your intestinal tract). 
  • People who find it difficult to take their thyroid medication on an empty stomach (due to side effects or schedule). 
  • People who are taking antacids, sucralfate,  or proton pump inhibitors (13) (these all lower stomach acid and may decrease how well your body can break down the inactive ingredients in medications like Synthroid and levothyroxine).

Remember:

Not every single person will react the same way to thyroid medication.

So even if you fall into the categories listed above doesn’t mean you HAVE to switch medications. 

But it does mean you should seriously consider it, especially if you are feeling poorly and you (or your doctor) don’t have a good explanation for it. 

Tirosint vs Tirosint-Sol

We won’t spend too much time on this topic but I want to quickly discuss the difference between Tirosint and Tirosint-Sol because I foresee this being an issue. 

Tirosint is a thyroid medication that has been available for some time and contains very few inactive fillers and ingredients

It is different from Tirosint-Sol, however, because it comes in a GEL CAPSULE. 

It is also different because it has a few more inactive ingredients compared to Tirosint-Sol. 

Tirosint-Sol, on the other hand, is a complete liquid that comes in ampules and which only contains water, glycerin, and thyroxine making it the cleanest thyroid medication available. 

Tirosint should also be differentiated from Tirosint-Sol because it is quite expensive. 

join 80000 thyroid patients

A month’s supply of Tirosint in a gel capsule will run you over $100 per month if you pay the cash price. 

Tirosint does have coupons available which you can take advantage of, however, to help reduce this price. 

In addition, there is now a generic Tirosint available from two pharmaceutical companies. 

These generic versions are brand new as of late 2020 and early 2021 but they can be added to the family of Tirosint medications. 

You now have the option of using Tirosint (brand name), Tirosint (generic), and Tirosint-Sol. 

In the past, I would typically start people directly on Tirosint because of these inactive ingredients (and skip levothyroxine/Synthroid), but that recommendation may switch to Tirosint-Sol in the future. 

How Much Does it Cost and Where can I get it?

At the time that I wrote this article, it was actually somewhat difficult to get Tirosint-Sol. 

Now that’s not the case. 

While it’s still expensive compared to other thyroid medications, it’s now available at many other locations. 

You can find Tirosint-Sol at pretty much every major box pharmacy out there including places like Walgreens, CVS, Costco, Target, and Walmart. 

The cash price for 30 ampules of 100mcg of Tirosint-Sol will run anywhere between $115 to $200 based on my own location and zip code: 

tirosint sol prices by pharmacy

This is obviously much more expensive than the generic $4 monthly price of something like levothyroxine but the price may be worth it if it means feeling better and having your life back. 

There are also other ways to help reduce the cost including some coupons from the manufacturer. 

There are some savings that you can find directly from the manufacturer here

These savings don’t work for everyone and do have some limits but you may be able to get them to work with your doctor. 

Another trick you can try is to ask your prescribing doctor for some samples. 

Doctors are often given samples of medications to give to patients so they can try them out. 

Sometimes these samples can be quite large!

If you can get your doctor to give you some samples then you may be able to try the medication out to see if it works for you before dropping the money. 

If you can get Tirosint-Sol at a price that is even remotely similar to that of levothyroxine then it’s a no-brainer. 

The increased absorption and flexibility in dosing will make jumping through some hoops well worth the process. 

Conclusion

If Tirosint-Sol continues to remain cost-effective (and cheap) then I honestly believe it may be worth it for MANY thyroid patients (probably the majority) to switch to it. 

The reason is simple:

In order for thyroid hormone to work, it must get into your body and bloodstream. And I think the number of people who suffer from thyroid hormone malabsorption (for a variety of reasons) is grossly underestimated. 

If you can afford Tirosint-Sol and you have a provider who is willing to give it a try, then I would at least consider a trial of this new medication. 

If the price of this medication shoots up to an unreasonable amount over the coming months then I may retract my statement, but I believe a great many people can benefit from using it right now. 

Now I want to hear from you:

Are you taking thyroid medication like Synthroid, levothyroxine, or Levoxyl?

Are these medications working for you?

Have you tried switching medications in the past?

Are you thinking about using Tirosint-Sol? Why or why not?

Leave your questions or comments below!

#1. https://www.ncbi.nlm.nih.gov/pubmed/28151692

#2. https://tirosintsol.com/

#3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1070767/

#4. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2699000/

#5. https://www.ncbi.nlm.nih.gov/pubmed/22933169

#6. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1337187/

#7. https://www.ncbi.nlm.nih.gov/pubmed/8585400

#8. https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/206977s000lbl.pdf

#9. https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/021402s017lbl.pdf

#10. https://www.ncbi.nlm.nih.gov/pubmed/17123345

#11. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3092723/

#12. https://www.ncbi.nlm.nih.gov/pubmed/17725434

#13. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1070767/

tirosint-sol is the cleanest thyroid medication on the market

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About Dr. Westin Childs

Hey! I'm Westin Childs D.O. (former Osteopathic Physician). I don't practice medicine anymore and instead specialize in helping people like YOU who have thyroid problems, hormone imbalances, and weight loss resistance. I love to write and share what I've learned over the years. I also happen to formulate the best supplements on the market (well, at least in my opinion!) and I'm proud to say that over 70,000+ people have used them over the last 6 years. You can read more about my own personal health journey and why I am so passionate about what I do here.

P.S. Need more help? Check out my free thyroid downloads and resources.

93 thoughts on “Tirosint-Sol: Is it Really Better Than Other Thyroid Medications?”

  1. Thank you for this update. I noticed it contained T4 only. Are there any suggestions for those of us needing a T4/T3 combination?

    Reply
    • Hi Lucy,

      Yes, this is a T4 only thyroid medication but it can be used with other T3 medications such as Cytomel, liothyronine or SR T3. If you are already doing well on NDT then you probably wouldn’t need to consider switching medications.

      Reply
    • hi Kathleen,

      Yes, it is synthetic. I don’t really like that term, however, because there is no “natural” thyroid medication. Even the natural thyroid medication is from animals and not from humans, so it’s only natural in the sense that it isn’t created in a lab.

      Reply
  2. Hello, I take Synthroid and my prescription bottle says Levothyroxine underneath.
    Does that mean it wasn’t available?
    Also would you know if Tirosint-Sol is available in Canada?
    Thanks for your help.

    Reply
    • Hi Ian,

      It sounds like you are on the generic for levothyroxine which is standard for most people. I’m not 100% sure if it’s available in Canada or not because different countries allow the use of different medications.

      You can always ask your doctor to see if they are willing to prescribe it to you, however.

      Reply
  3. Thank you so much for this info! I’ve been taking Synthroid for 32 years. My TSH was high in recent blood work. I have a new PCP who is a DO. Could be an absorption issue due to drinking my morning coffee 30 minutes after taking my Synthroid instead of waiting an hour like I was doing. I’m going back to waiting an hour and will have a repeat blood draw in 6 weeks. I have Celiac, too, and am sensitive to chemicals and additives, etc.. I am excited about Tiring Sol! I plan to ask my new PCP about it in 6 weeks after I get my test results. I believe your email and this info is an answer to prayer!

    Reply
    • Hi Vicki,

      Glad you found it helpful! And yes, coffee can definitely interfere with thyroid medication absorption. Several studies have shown this to be the case. Coffee can also suppress T3/T4 levels as well.

      Reply
  4. Thank you so much for this information. I no longer have a thyroid (removed after thyroid cancer almost 20 years ago). I’m going to talk to my doc about switching. One question. Will this or any medication ‘normalize’ my TSH number? TSH results generally confuse me – it’s always “too low” on the labs but I don’t have a thyroid so I can’t see why it matters as long as the other numbers are in range. Thanks so much.

    Reply
    • Hi Debbie,

      Yes, all thyroid medications will lower the TSH through feedback loops in the brain. Most endocrinologists use the TSH as a way to fine-tune your dose of medication. I don’t believe that this is the best method for finding the correct dose, but most people do it because it’s so “easy”.

      Reply
  5. I did not do well on Thyroxine, many years trying different doses etc. Tried adding T3 as a combo, too hard having to multi dose…. now taking NDT THYROVANZ.
    I am in Australia, will Tirosint Sol be available here?

    Reply
    • Hi Trish,

      I’m not sure, each country has its own set of bodies that determine if they will allow a new drug in. You can always call a local pharmacy and ask if they have any plans of getting it and they can give you more information.

      Reply
  6. I’m going to my doctor on Thursday and I am going to tell her about this. I was on desiccated thyroid medicine for 3 months, for the first time ever, and my t4 surprisingly dropped 2 full points. Do you know why? I’m pretty disappointed in the medicine actually.

    Reply
    • Hi Eboney,

      Yes, any medication with T3 in it may cause a drop in T4 levels. Some people on NDT seem to be more sensitive to this effect than others.

      Reply
  7. I am pretty sure I have side affects from inactive ingredients in the Levothyroxine. I did however switch to the 50mcgs, take 1 and a half a day in the AM, as I read it doesn’t have an ingredient all the others have. I’m also on Liothyronine 5 m (1 twice a day). I take Dexilant as I have gerd. I feel like this Tirosint-Sol may benefit me because of low acid. I have always waited at least a half an hour to drink coffee after my dosage and a full hour for food, so this liquid thyroid will enable me to take whenever? Also, do you treat patients ever with JUST cytomel or is it always a combo of the tirosint or Levo and the liothyronine. That’s a question out of curiosity. My numbers did seem to be in range and I actually had my Levo dose lowered after taking cytomel WITH my Levo. Anyway, thanks in advance for your answer!! I soooo wish you were in Texas!!! Thanks Doc!

    Reply
    • Hi Renee,

      You can theoretically take this and Tirosint (the original) with food and with coffee without any issue, but I still wouldn’t recommend it.

      And yes, you can take T3 medications without T4, but I generally don’t advise it for everyone.

      Reply
  8. I tried to switch to tirosint. Dr lowered my dose because she said it could seem stronger since it was going straight into my system. I only took 25mcg of synthroid so we tired lowest dose of tirosint which is 13mcg. I normally take my med around 4am when I wake to use restroom so I continued that schedule. The first night I took it, about an hour later I woke up with almost a rush of adrenaline. So next night I tired again, same thing. I took it one more night and just couldn’t deal with that feeling. I went back to synthroid on 4th night. I’m super bummed it didn’t work for me. I also had my numbers check a few weeks later and my tsh went from 1.61 to 3.96 and my tpo went from 5 to 66! I have been wondering if maybe I was going into a Hashimotos flair and it was a Coincidence that it happened when I changed medication or if the lower dose did it?

    Reply
    • Hi Christina,

      Yes, there are a number of factors that could have contributed to your symptoms when you took it. Also, you are probably referring to using Tirosint and not Tirosint-Sol which is what this article is about.

      Both are new, but Tirosint-Sol is newer.

      Reply
  9. I am a type 1 diabetic and I have hashimotos. I took nature throid for 3 months and levothyroxine for 1 month and my blood sugars ran 300-500. I had to quit taking thyroid medicine. I would love to take Tirosint-Sol but will it raise my blood sugar?

    Reply
  10. Thank you for the info on Tyrosint-Sol. I plan to ask my doctor about it. I was previously taking Nature-throid for hypothyroidism and did very well with it. Because it is no longer available, I switched to Armour thyroid several months ago. In just five months my TSH has gone from .647 to 0.18 with my T3 and T4 levels staying within normal range. I am experiencing symptoms of fatigue, joint pain, and very dry itchy skin. I would value your input.

    Reply
  11. After having side effects to levothyroxine, my endo switched me to Tirosint – 7mcg an titrated up. TSH sill increased. After consulting with a Functional-Integrative group, a test revealed my body wasn’t able to convert T4 to T3. I am now taking Cytomel. How long does it take to feel side effects from this medication? I’m keeping a symptoms diary – noting side effects Day One. Is this considered “typical”? Thank you!

    Reply
  12. Thank you, so much, Dr. Childs. I just picked up my prescription. Wondering if you might comment on the best time to take the tirosint sol.
    sincerely, Helen Hartley

    Reply
  13. Doctor. I had my thyroid removed 16 years ago when I was 22 years old! From that day until January 24, 2019, I had been on Levothyroxine and felt awful! Finally found a doctor who added cytomel to my Levothyroxine with no results except feeling worse! So at the end of February, she allowed me to change to NP THYROID because WP and Nature throid isn’t available anywhere around right now, and I had waited for the Nature throid! The NP has caused a rash under my chin of large itchy bumps? Will they go away? Do you have an opinion on what I should try? I also have PCOS and diabetes type 2! Can I up the np thyroid? I’m currently taking 120mg the largest dose with tiredness! I also take daily adrenal support, d3 5000, b12 and b complex. Thank you so much!!

    Reply
  14. I have recently switched from Synthroid to Levoxyl because of cost. I’m not feeling well and have most of the allergic side effects you listed in your article, most especially severe joint pain and wheezing. I had these side effects with Synthroid also, but not as severe.
    I had my thyroid removed 16 years ago due to cancer. Would you recommend tirisint – sol or tirosint for me?

    Reply
    • Hi Mary,

      It wouldn’t hurt to try either of them, to be honest. As to which one you will do best on, that’s a matter of trial and error.

      Reply
  15. Thank you for all of the information. I’m on 137.5 mcg Levothyroxine. I have to stay in a hypo state in order to not have a screaming headache. My hair is extremely thin, and I have steadily gained weight since my total thyroidectomy in Oct 2016. I am asking my doctor for Tyrosint tomorrow morning. I’m excited to give the SOL a try, but my pharmacy said to give it a few months to get more out to the pharmacies. Hopefully this is a game changer for me! Thanks for all of the great information you provided.

    Reply
    • Hi Jamie,

      You are welcome! Tirosint-Sol should definitely be out in more pharmacies as time passes but it is still very new.

      Reply
  16. Extremely informative! Totally supports/validates all the research I’ve done in last 20 years. Now 70, I’ve been on Synthroid since I was 50 but needed it when I was 30. Of course my PCP thought I was just fat, forty, and female who needed to diet and exercise in spite of strong family history of Hashimotos. Never even had a doctor actually feel of my neck/thyroid gland until I was 50. Although I was fortunate to have an immediate, positive result from Synthroid recent issues make me think it’s time to change so I had already been considering Tirosint. So blessed to discover your site and stoked to try the Tirosint-Sol. Thank you!

    Reply
  17. I have been on tirosint for 4 months, am experiencing a sore neck and shoulders. My doctor wants me to switch to Levoxyl at the same dose. Would the tirosint-sol be a better option for me?
    Thanks, kathy Conway

    Reply
  18. I started taking Tirosint-Sol 137mcg about 2 weeks ago and I am have having terrible acid reflux and GERD symptoms. I don’t dilute the ampule in water but I do drink quite a bit of water after I swallow the dose. I usually go back to sleep after taking the medication. I can’t find anything in the package insert about staying upright for a determined amount of time after ingesting the medication. Nor can I find anything about acid reflux or GERD is a side effect of this medication. Is there anything that I should be doing differently to avoid these issues?

    Reply
  19. I have been refusing to go on medication because I fear side effects and have a deep mistrust of the pharmaceutical industry. I tried NDT for a few months and did great until I started waking up with swollen lips every morning. Stopped taking it, and that stopped happening.

    I was considering Tirosint-Sol because I have so many sensitivities, but recent patient reviews (drugs.com) indicate that some patients were happy on Tirosint and suddenly started having all kinds of horrible problems. Then they learned that Tirosint has recently changed manufacturers (I think the owner is actually manufacturing it themselves rather than outsourcing it as they had been). This is incredibly discouraging to read. Is it really that hard for manufacturers to duplicate a formula? I have emailed the company to see what they can tell me about this. Will let you know what they say (although I’m not expecting a lot of helpful info from them). I think the reviews were about Tirosint, but I would assume that any inconsistency issues with Tirosint could also impact Tirosint Sol?

    Also, I just read Sheila’s comment above mine and would also love to hear your thoughts, as I have GERD too.

    Thanks so much for all you do, Dr. Childs!

    Reply
  20. I am over 75 yrs. old. I have been exhausted all my life. Synthroid never helped and I have been taking Levothyroxine, 50 mcg, tablet for several years. One doctor told me, “your thyroid is dead.” Needless to say, I am exhausted. All side effects apply to me. Currently I am waiting to see an Endocrinologist for several nodules on my thyroid. The nodules were needle biopsied about 4 years ago and were benign. I know the nodules are bigger now because I find it harder to swallow food, my throat is sore and my voice is hoarse. My neck feels full and uncomfortable. So far, doctors are useless. Blood tests come back normal, in normal range, and that’s it. Medication stays the same and no further testing is ordered. When I was young and pregnant (twice) my thyroid dosage was raised and I felt like a million dollars. After babies were born, my dosage was lowered to previous strength. Then I was back to being exhausted. I plan to print your article and give it to the new doctors I will see in the near future. Thank you for posting your article, and because you did, I have a hope that I haven’t had for years.

    Reply
  21. I am on Nature-throid 98mg daily. I have been taking Mag Oxide faithfully for months and after reading this I will immediately switch to citrate.
    My provider is not sure if I’m hypo or hyper thyroid cuz my labs are all over the place. I have had some mild weight gain, dry skin, constipation. I am still an active 65!
    What do you think of Nature-throid?

    Reply
  22. I know this is an older blog, but I just wanted you to know that I just switched over to Tirosint-sol after first being on Armour, then Naturthroid and finally NP. (I was on synthroid for years before I began my journey with NDT). I did well on all the NDT’s until they each changed their formulas. After finding out that NP changed as well and many people had horrible symptoms along with hypo symptoms that came back, I switched to Thyrovanz. I began waking up each morning with many itchy welts and allergy medicines wouldn’t help. sigh…

    So, finding this information about Tirosint-Sol seemed timely. (I also have many gut issues that I suspect were from being severely under dosed and from all the formulation changes). So, today begins my last ditch effort in hopes that Tirosint-Sol will work for me and that they will continue to offer the coupons so that I can afford to take a medicine that is close to $500 for three months!

    I am very curious if others have used it (I understand it’s super new), and maybe had really good luck on it? I did read some reviews and was disheartened by what I saw, but am trying to give it time and hoping I settle into this. I really need to get my old life back.

    So, if anyone IS on Tirosint-sol and are doing well on it, please post and share so that I can have a bit of encouragement while I wait the 4-6 weeks to see if it works for me.

    Reply
  23. I just started Tirosint Sol. I’ve always been on NDT. First WP thyroid then NP when WP became unavailable. I did so well. I lost a lot of weight and was living the best life. That all ended. NP did something to their medication and it makes me terribly sick. After searching hard I found WP. It too has changed and is worthless. I even tried compounded NDT and t3/t4. The capsules made me sick with the NDT and the t3 in the other felt like it was way too much. I have celiac and many sensitivities. I have taken Levothryoxine once before and it caused me severe shoulder wrist and finger pain. I also swelled. This was before I went gluten free or knew of my gluten sensitivity. I tried Tirosint capsules and it hurt my stomach for some reason. This is my last hope. I was on 30mg NDT and have taken 50mcg of Levothryoxine in the past. I started on 25mcg of Tirosint Sol. I hope this works for me. I have nothing else.

    Reply
  24. My doctor recently gave me trials of tirosint sol. I have been taking it for just over a month with no issues. I have malabsorption issues due to having bariatric surgery, so we are hoping that my next round of labs will show a difference. My only concern is whether or not my insurance will cover it. I have to say that I was worried that the taste of the liquid would make me gag, but it actually doesn’t taste bad. I hate swallowing pills, so that alone is a win for me.

    Reply
    • Hi Amy,

      Insurance hates to pay for Tirosint but they do have some coupon codes that may work for you that you should try if they balk at payment.

      Reply
  25. Dr. Childs,

    Might some people have trouble with the glycerine in Tirosint and Tirosint-Sol? Do I understand correctly that it is often called glycerol and is a sugar alcohol? Sorbitol and mannitol give me headaches.

    Thanks.
    Dale

    Reply
    • Hi Dale,

      I’ve never seen anyone react to the glycerin personally but I’m sure it’s possible. You are correct that it is a polyol compound.

      Reply
  26. I love your site,, which I came upon by accident. I am having trouble sleeping and wake every morning with tremors. My PCP sent me to a neurologist who said I don’t have a neurological problem, she thinks it’s from my new asthma inhalers, so I stopped Perforomist and continue taking Budesonide & Ventolin. After 6 months of these symptoms, I remembered getting my Tirosint 13 mcg from a different manufacturer, so could that be the reason for the tremors?

    Reply
  27. I was on Tirosint but my body metabolizes very quickly and I was crashing in afternoon. My doctor switched me to a compounded T4/T3 with extra methocel (50%) but I’ve gained weight rapidly! I am hoping to go back to a tirosint amd compounded T3 and just do 2 doses to sustain me. ExoressScriots actually was great and covered tirosint for me for $4 due to absorption issues with every other med I’ve tried. But now my husbands insurance switched to OptumRx who I’m not impressed with!! They don’t want to cover it any longer so I may try the SOL if my dr allows since it’s cheaper with the coupon code.

    Reply
  28. I just came across this article because I am having an absurdly hard time regulating on Armor (right now it’s back to 2.5 grains split into two doses) I was on Tirosint plus a compounded T3 for years before I had my fourth child. Ever since V has been born (she just turned two) I can’t regulate my Hashimoto’s it’s in constant flux. I am going to my doc tomorrow and had planned on begging for Tirosint and T3 but now maybe I’ll bring up Tirosint-Sol. Thank you.

    Reply
  29. I only have half a thyroid. Had a cyst on right side so it was removed. I do not currently take meds but I know when my thyroid is out of whack. I have struggled with the weight gaining for the last 20 years. My results always come back in the “normal range”. Do you think this new medicine would helo me?

    Reply
  30. Hi there,
    First, thank you for a very well explained video describing Tirosint.
    My endo diagnosed me with sub clinical hypothyroidism in early 2019. I first tried Armour thyroid30-60mg, my labs improved as she wanted me at an “optimal level.” However, the side effects were HORRIBLE! I started having heart palpitations, and experienced my first ever anxiety attack, no fun! She then put me on levothyroxine, that somewhat helped but then I started noticing major hair shedding. She then prescribed Synthyroid 50mcg, and I still have hair shedding. Finally, today (3/31/20), she wants me to try Tirosint 50mcg, I bought the medication which was $127, kind of pricey but I’ll pay anything just to stop this hair loss and start seeing the benefits of my thyroid medication.
    I plan to start this medication tomorrow, but had a little concerns and questions.
    1. I know i’m extremely sensitive to armour thyroid and stimulants. Will this medication cause any anxiety or heart palpitations or nervousness?
    2. Was I likely losing hair because of the “fillers” in my Synthroid medication?

    Thank you again for your help and guidance with this new drug! Any feedback is helpful!

    Reply
  31. Hi, I could use some help to just figure out if this is something in my head or a realistic thing that could happen. My doctor also thinks it might be going through perimenopause and anxiety has been a part of that.

    Anyways, I’ve been on tirosint regular gel caps and I was on 50mcg. I did take a 75 gel cap the night before and didn’t feel anything and slept good. I was switched over to The Tirosint SOL at my request which is a liquid. I took the liquid last night and then I felt like for the next 3 hours I couldn’t sleep and my heart felt like it kept palpitating. I felt it as soon as I took the medication so I’m wondering if my anxiety kicked in or could a liquid medication really cause that.

    I will admit I went into the medication with anxiety.

    Now, my heart feels fine.

    Reply
  32. Hi Dr. Childs,

    How would one go about converting from NDT to Tyrosint-Sol? I’m currently taking 113.5 mcg of NatureThroid plus 10 mcg of Liothyronine (divided into two 5mcg doses) daily. Would I keep my dose of Liothyronine the same and start with a low dose of Tyrosint-Sol to be safe?

    Thanks,
    Renee

    Reply
    • I tried to take my usual dose when switching to Tirosint gel capsules 88mcg and it was too much. I started getting heart flutters, weepy, head numbness, and depression, and acid reflux. I went down to 75 mcg then started getting wrist and foot pain and body fatigue with the acid reflux.
      I haven’t tried the Sol solution so I can’t say but one can assume it may be stronger because it’s more absorbed so be prepared to move down some if you have those symptoms. I’m not a person with absorption issues, however and my T4 levels on levothyroxine were always a bit on the high side already.

      Reply
  33. I gave Tirosint Gel capsules a try but suffered extreme acid reflux which caused burning, coughing and choking on two different doses. It resolved within two days of discontinuing. I don’t have this issue with pill forms.
    Do you think I could avoid this issue on Tirosint Sol? I also have the issue of one dose too strong and the other too low. This isn’t exactly a cheap medication to have to mix and match. How does a person handle this issue with a medication that you can’t split?

    Reply
  34. Thank you for this info! I switched to Tirosint-SOL recently after having my numbers “crash” from the WP Thyroid recall (I was doing so well on the 65mg of WP Thyroid). I started on 50mcg of the Tirosint-SOL along with my 2 doses of 15mcg of compounded T3 each day 3 weeks ago now. Still not feeling the best and was thinking bout adding a second dose of the Tirosint-SOL in the afternoon (with my Drs permission of course). What are your thoughts on taking the Tirosint-SOL twice a day for optimal benefits? I know I’ve heard that the T3 only stays in the body about 4 hours so that is why I take it early am and again mid morning. Thanks for your help!

    Reply
    • Hi Sarah,

      There probably is little to no benefit of split dosing Tirosint/T4. The reason is because one dose of Tirosint will stay in your body for about 4 weeks.

      Reply
  35. Hi Dr. Childs,

    I recently switched to Tirosint from levothyroxine and have been feeling so much better. I have celiac disease and many food sensitivities. However, I am very sensitive to thyroid hormone and find that 13mcg daily feels like too high of a dosage (I am a slow metabolizer-with 13mcg daily I start to feel sweaty, my eyes swell, etc., however without any thyroid medicine I can barely function). Is there any way to “split” the dose of Tirosint sol? I am considering this as an alternative. Do you understand if diluting in water and waiting a day to drink the other half of the cup would affect its activity? Due to the packaging of the ampules, it is a bit challenging to take only half without wasting the rest of the dose.

    Thank you very much for all of your knowledge and expertise, you have changed my life!

    Reply
  36. Hi. I found your article very interesting. I had a TSH that started getting lower and lower numbers back in 2001. I finally requested a consult with an endocrinologist in 2008 bc my hair had started falling out, I was tired all the time. I had a thyroid sonogram which showed nodules, neither hot nor cold. I was told I had a toxic multinodular goiter. But it could be solved with a thyroidectomy. So I had a thyroidectomy and lo and behold, it was malignant. So since 2009 I’ve not been able to keep my TSH on and even keel. I am considering talking to my provider about this medication. Thank you very much for this information.

    Reply
  37. Hello Dr. Childs,

    I’ve read that eating walnuts can interfere with Tirosint Sol. Should I not eat walnuts or do I need to inform my doctor in order to increase my Tirosint Sol dosage. Walnuts have many health benefits. Thank you

    Reply
  38. Dr. Child’s, thank you for the info on Tirosint-Sol. Recently visited a new Endo Dr. who is recommending the Tirosint med. He is the 1st dr. In a while who didn’t first spout out my need to watch diet & do exercise.
    Instead he listened to all my thyroid issues, then explained why I was probably not able to process the levothyroxine pill and recommended Tirosint. Pending bloodwork results he feels it would be a good choice to help restore my health. For the first time in about 10 yrs. I am hopeful. Thanks for your info!

    Reply
  39. Hi Dr. Westin Childs,
    I am using Tirosint Sol. If the medication just has 3 ingredients, what gives it the syrupy almost honey tasting sweet flavor? There has to be a sweetener in this. Do you have any information relating to this?

    Thank you.

    Reply
  40. After reading your article, I am considering trying the tirosent-sol. I have been on Synthroid 112 mcg since my total thyroidectomy. Life is difficult. Weight gain is a constant battle, despite diet and exercise. I am always hungry, like sever hunger pains, when I know I should not be. Body aches and brain fog. I fired my endo, because he would not listen to me. I have a new doctor now who listens to me and has suggested this medicine. However, I have heard you will lose your hair. I lost some with synthroid originally but it leveled out. Will switching from synthoid to tirosent-sol really cause as much hair loss as people are saying?

    Reply
  41. Hello Dr. Child,
    After taking synthroid for 40 years, I have decided to give Tirosint sol a try. My hypothryroid symptoms and fibromyalgia never resolved with synthroid.
    I am taking 5 mcg of slow release T3 from a compounding pharmacy.
    Should I take my T3 capsule at the same time with the tirosint sol? or appart?
    Could it happen that I won’t need T3 anymore the improve absorption of T4 from the tirosint sol? If my body starts converting well?

    Reply
    • Hi Rosa,

      It’s usually best to take T4 and T3 apart. Some people can get away taking them together, especially if you are using Tirosint or Tirosint-sol, but spreading them apart is still the safer approach.

      It’s possible that Tirosint may necessitate that you reduce your dose of T3.

      Reply
  42. Hello Dr Child’s,
    I just switched to tirosint sol about 3 months ago.
    Took synthroid all my live since 16 years old now I am 65.
    I was taking 0.75 of synthroid and recently added 5 mcg of slow release T3 since never felt well from hypo. I don t have hashis
    Since I started T3 I have bad leg pain. So know that is switched to tirosint sol 62.5 I want to stop the T3, and see how I do.
    Is there a possibility that if my body absorbed tirosint sol better that I might not need to supplement with T3?

    .

    Reply
      • Thanks for your feed back!. Have you ever had anyone complain of leg pain with such a small amount of slow release T3?
        And my hair has been falling off like crazy even before I started the T3.
        Please see my note bellow, where I sent you my lab results and the time line.
        I really value your feedback!!. After you see my history in my note bellow.
        Warm Regards,
        Rosa Bazzani RN BSN IBCLC

        Reply
        • Hi Rosa,

          Unfortunately, I can’t provide medical advice over the internet but I can tell you that I’ve really never seen anyone react with leg pain to small doses of T3. That doesn’t mean it can’t happen, though.

          Reply
  43. I take T3. I can not tolerate it. Even a low dosage. So, I had to stop. I don’t understand why this happens. Any ideas? I’m frustrated because I have hypothyroidism and am unable to do anything about it.

    Reply
    • Hi Donna,

      Some people just can’t tolerate T3, even at small doses. You can try getting T3 through slow-release capsules or getting it in something like NDT. These options may work.

      Reply
  44. Hello Dr. Child,
    Here are my results from 3 months ago taking synthroid 0.75 and 5 mcg of slow release T3 (compounded):
    Reverse T3 -27 (high)
    Free T4- 1.5
    TSH-0.4
    Free T3- 3.0
    After these results I started on tirosint sol 62.2. And continued with 5 mcg of slow release T3.
    I always had an issue with leg pains like muscular spasms, ever since I started on the T3 and also a lot of hair loss even before starting the T3.
    So Being a Registered Nurse myself I decided to try the tirosint sol which like you said so wisely is a cleaner preparation but since I was having leg pains I want to try only the tirosint sol and stop the slow release T3 and see how my body does.
    Have you ever heard of muscular pains with T3?
    It sounds weird to me. But every one reacts differently I guess. Please give me your feed back on this issues.
    Should I decrease the tirosint dosage? I went from 0.75 synthroid down to 62.5 tirosint so I lowered it a tinny bit.
    Most doctors don’t have a clue on how to work with compounded slow release T3 and don’t know about tirosint sol either.
    Your knowledge, your videos and teaching has help me and so manny others.
    I am so grateful of having you and you being a light of knowledge for so manny.

    Rosa

    Reply
  45. I am so glad I found this article. I will be giving a copy to my doctor at my next visit. I have tried every thyroid medication possible with no success. The Tirosint did work well for a while but then I started developing severe stomach pain. I stopped the Tirosint for a small time and then I tried the Tirosint again. Within two weeks I had stomach pains so severe I was doubled over. I stopped completely taking the medication. I am allergic to a lot of stuff, but with only three ingredients hopefully, it will work. What bothers me is the price. Holy cow! I am retired and the cost is high for me. I hope that my doctor and I can work something out with the company or maybe my provider?? Thank you for your time.

    Reply
    • Hi Wendellyn,

      There are some manufacturer coupons that you can look at, your doctor may also have some samples he/she can give you as well. It’s worth asking about!

      At the end of the day, the cost is worth it if it helps you feel better.

      Reply
  46. Hello Dr. Child,
    If you scroll up a bit you can see I sent you my last lab values and some questions.
    Could you take a look and give some feed back?

    Thank you so much, I would really appreciate it!

    Reply
  47. Hi Dr. Childs,
    could you give some feed back on my lab values and questions on the above post?

    Warm Regards,
    Rosa

    Reply

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