Leptin Resistance Rx | Leptin Sensitizer with ORALVISC & GAGs

Leptin Resistance Rx | Leptin Sensitizer with ORALVISC & GAGs for Metabolic Support (60 Count)

$69.99 or subscribe and save 5%

Leptin Resistance Rx is a weight loss support supplement that features ORALVISC, a trademarked blend of hyaluronic acid and glycosaminoglycans designed to help you lose weight, control your appetite, and manage leptin resistance when used with healthy lifestyle changes.*

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Manufactured in The USA

Third-party tested for purity

60-day Money Back Guarantee


Lose Weight By Targeting Your Fat Cells & Leptin Levels

Is Leptin Resistance Rx a magical weight loss pill that will help you effortlessly shed pounds and melt body fat while eating whatever you want?

No, definitely not!

But it is a weight loss support supplement that contains tested and researched ingredients that can support your weight loss efforts when combined with healthy lifestyle changes like eating a whole food diet, exercising regularly, and fasting intermittently.

And when you purchase any supplement from Dr. Westin Childs you get the added benefit of knowing:

  • Every single supplement is third-party tested by an ISO-accredited lab for purity, contaminants, microbes, mold, and heavy metals.
  • Total transparency is the standard when it comes to reviews and opinions from people who have used our supplements (we have a 99% transparency medal from our third-party review aggregator judge.me)
  • All of my supplements are made in an FDA-inspected and GMP-compliant facility.
  • And that we have a 60-day no-questions-asked money-back return policy.

With all of this in mind, let’s talk about how Leptin Resistance can help you:

Leptin Resistance Rx is an over-the-counter supplement that contains a blend of glycosaminoglycans (GAGs for short) and hyaluronic acid combined with vitamin C designed with one purpose:

To target the most important hormone responsible for regulating fat cells in your body…


The result?

It is one of the very few ingredients that have been shown in in-vitro, human, and animal trials to help lower serum leptin levels, manage body weight, and impact inflammatory markers.

Based on my research and experience, I’ve found leptin to be one of the most important markers of weight loss success.

Those people who are able to manage their leptin levels are better able to burn fat and build muscle mass compared to those who neglect them.

But the key to losing weight and keeping it off isn’t just about taking a supplement and calling it a day, it’s about putting together a comprehensive program that includes your diet and exercise routine as well.

How Lowering Your Leptin Level Will Help You Lose Weight

The reason targeting leptin levels is so important for weight loss is because of what it does for the body.

Leptin’s primary responsibility is to act as a messenger between your fat cells and your brain.

As fat cells increase in volume, leptin levels increase.

The rise in leptin is supposed to stimulate your brain to make changes to your appetite and metabolism to compensate for the increase in fat.

But this communication breaks down in certain inflammatory states and when your fat cells get sick (known as adiposopathy).

If your fat cells can no longer communicate with your brain, then you end up with an increase in appetite and a slowing of your metabolism when you really need the opposite.

This state is called leptin resistance and it’s a problem that just about every person who can’t lose weight is experiencing to some degree or another.

The key to weight loss is re-establishing the connection between your fat cells and your brain so that your metabolism can increase and your appetite is better controlled.

Targeting leptin does just that.

As you lower leptin levels your brain becomes more sensitive to the hormone which means it can receive the message more effectively.

Leptin Resistance Rx may help fight leptin resistance by helping to lower serum leptin levels (thereby sensitizing your body to leptin), by helping to reduce inflammation (thereby indirectly improving thyroid function), and by improving fat cell turnover by influencing genetic markers on fat cells.

Dr westin childs photo

Why Dr. Childs Recommends It

“If weight loss is your primary goal then I can’t think of anything more important than targeting and managing your leptin levels.

Leptin is one of if not the primary regulators of adipose tissue and metabolism and represents a unique target for treatments like supplements and medications.”

Used by over 80,000+ people who have left over 10,000+ reviews

Ingredients That Work

Ingredients and dosages are thoughtfully chosen, relentlessly tested, and continually refined.

Physician Formulated

All formulas have been created by Dr. Westin Childs based on his clinical experience and evaluation of peer-reviewed scientific research.

Made in the USA

Our supplements are proudly made in the USA, with globally sourced ingredients, in a GMP-compliant facility and shipped from Mesa, Arizona.  

Third-Party Tested

Every single supplement lot is third-party tested for heavy metals, microbes, mold, and contaminants by an ISO-accredited lab testing facility.

Free Domestic Shipping

Every order (regardless of price) placed in the U.S.A. will ship free with USPS.

60-Day Money Back Guarantee

If you don’t love your supplements then you can return them for a full refund! No questions asked and no hoops to jump through. 

Frequently Asked Questions

In short, yes, it will help you lose weight but it should never just be used by itself as something that you plan on taking without any extra effort.

Here’s what I mean:

Leptin Resistance Rx is best thought of as a supplement that puts your body into a state where weight loss becomes much easier than it was previously.

But just putting your body into that state doesn’t mean you will lose weight.

You need other inputs from things like your diet, or your exercise routine, or from fasting to actually initiate the weight loss.

In this way, Leptin Resistance Rx makes weight loss easier but doesn’t cause it all by itself.

I’m so glad you asked!

If you want to lose weight, keep it off, and change your body into a well-oiled machine then you need to be doing more than taking supplements.

Yes, supplements can absolutely help, but they don’t replace important lifestyle changes like diet and exercise.

No matter what you are doing, these need to be done as well.

Based on my extensive research in helping patients with weight loss, here’s what works best when using Leptin Resistance Rx:

  • A whole food diet (I’ve seen just about every single one work including the ketogenic diet, carnivore diet, low carb, vegan, whole30, etc. Just make sure to find a whole food diet that works for you).
  • Regular exercise at least 3-5 times per week. My preference is weight lifting as it helps with weight loss and building muscle mass but anything that puts stress on the body will work.
  • Intermittent fasting. If you are overweight then going for several hours to even a full day without food is incredibly helpful for balancing fat-storing hormones like leptin resistance and insulin resistance. My favorite fasting protocols include 2, 24-hour fasts each week, one meal a day, every other day fasting, or 16-hour fasting windows (see more information below).

Fasting is simply going without food for a set period of time and it’s been a regular part of cultures and religions for thousands of years.

Taking advantage of fasting as a therapy allows you to get more benefits out of weight loss therapies including supplements, medications, and even exercise.

If you are new to fasting, here are several protocols that can be considered (I’ve seen them all work):

  • 2, 24-hour fasts each week: This fasting protocol is easy, you just take 2 days out of the week and you go without food for a 24-hour period.
  • Every other day fasting (3, 24-hour fasts each week): Every other day fasting is very similar but you can pick whatever 3 days work best for you based on your schedule. Most people who use this method do 1, 24 hour fast on Monday then again on Wednesday then again on Friday.
  • OMAD (one meal a day): One meal a day is exactly as it sounds, you eat one gigantic meal each day.
  • 16-hour fasting windows: This is similar to the one meal a dan plan but it allows you to eat for an 8-hour window (as opposed to just one meal) every day. This means that each day you will be fasting for at least 16 hours. This is an easier way to jump into fasting if some of the other options seem too intense for you.

Don’t be afraid to play around with these fasting protocols to find something that works best for your body and your situation!

No matter what you do, just make sure you are doing some form of fasting if you are trying to lose weight!

Great question!

I have a somewhat unique approach to weight loss in that I believe hormones are the primary driver of weight gain.

This means that therapies that balance hormones are often much more impactful on weight than therapies that focus primarily on calories.

Leptin Resistance Rx is one of those therapies because it targets leptin levels.

If you have a very severe case of weight loss resistance then you are someone who may ultimately need more aggressive therapies beyond just supplements and lifestyle changes.

If that’s you then you will probably find these case study walk-throughs very beneficial:

These case studies are from real people who have used my methods with great success.

And the links above will walk you through everything they used to lose weight and keep it off including what type of diet they used, the supplements they took, the medications and hormones that they needed, and much more.

I’ve also included a lot of additional information including how to use hormones, therapies, and other supplements to help with weight loss in my 60-day weight loss program.

My 60-day weight loss program is found inside my weight loss supplement bundle.


Leptin Resistance Rx contains ingredients that are not commonly found in pretty much any other weight loss supplement or medication which means that it can be combined with them without any issue.

It’s also even more beneficial to do what I call therapy stacking, which is the addition of multiple weight loss therapies on top of each other if you are interested in weight loss.

The more therapies you add, the better synergy and success you will see.

That depends on a lot of factors including how you are checking but, for most people, you should expect to see results in about 4-6 weeks.

Whenever you are losing weight the right way, it will always be a slow and steady process.

Any diet or weight loss therapy that promises fast results will almost always come with unwanted side effects like metabolic damage.

Safe and effective weight loss, on the other hand, allows you to lose weight and keep it off while also improving your overall health.

For most people, you should expect to start seeing the scale moving downward within about 6 weeks of daily consistent use.

In reality, the benefits will be seen almost right away, but it takes time for those changes which are occurring at the cellular level to manifest in your overall weight, muscle mass, and fat mass.

Again, this is completely normal and is standard for weight loss therapies that help you lose weight the right way.

When you are losing weight in a safe and effective way the best way to measure your success is not the scale!

Here’s why:

The scale is a measurement of your total body mass which takes into account many factors including your fat mass, your muscle mass, and your water weight.

What most people who need to lose weight fail to understand is that obesity causes a combination of two things:

A decline in muscle mass and a rise in fat mass.

When you start losing weight correctly, your body will naturally build muscle mass while burning fat mass simultaneously.

When this occurs the scale stays the same (at least initially) and this is perfectly normal!

It’s actually a good thing, too, because muscle mass is much more metabolically active and will help you lose more weight down the road.

At some point, your muscles will reach a steady state and they will no longer grow (unless you are specifically focused on them with strength training).

When this happens, you will start to see the scale move downward.

This process takes around 4-6 weeks which is why using the scale for the first 1-2 months is a very poor metric of your success.

A better tool to assess whether or not what you are doing is working is to use body measurements.

You’ve probably heard the adage that muscle is heavier than fat, right? Even though your total weight will stay the same initially, the size of your body will shrink.

Body measurements provide a safe and easy tool to assess for body fat loss while also taking into account the building of muscle mass.

For best results, take the following measurements when you start and periodically (every 1-2 weeks) as needed:

  • Hips: Find the widest part of your glutes and take the measurement.
  • Chest: Find the widest part of your chest and take the measurement (be mindful of your menstrual cycle which can impact your breast size)
  • Thighs: Find the midpoint between the lower glutes and the back of the knee, and take your measurement here.
  • Waist: Find the narrowest part of your natural waist and take your measurement.
  • Arms: Find the midpoint between your shoulder bone and the elbow of your arm. Take the measurement here.

Oralvisc is a trademarked, proprietary blend that contains roughly 70% hyaluronic acid and glycosaminoglycans and is the active ingredient in Leptin Resistance Rx.

It is included in this supplement because it has been shown to impact body weight, inflammatory levels, and leptin levels in in-vitro, animal, and human studies.

Yes! If you are feeling like you need more assistance then I have multiple resources that can help.

If you want something to help guide you through the weight loss process then my 60-day weight loss program would be a great option.

It contains meal plans, medication guides, a supplement guide, a detox guide, and much more.

It’s built into my weight loss supplement support bundle at no extra charge.

If you are looking for some free information just so you can learn more then I would recommend checking out the many articles I’ve written and videos I’ve produced on the topic of weight loss.

Yes! It doesn’t contain any calories which means it will not negatively impact your fast.

Feel free to supplement with Leptin Resistance Rx at any time of the day including during your fast.

Unfortunately, we are not able to ship Leptin Resistance Rx to those who reside in Canada.

ORALVISC, the active ingredient, is considered a pharmaceutical in Canada which means we can’t ship it across the border. We are still able to ship ORALVISC to every state in the United States, however.

The formula did NOT change and Leptin Resistance Rx is still the exact same as it was previously.

We recently changed the capsule from a red capsule to a clear capsule for 2 main reasons:

#1. Due to shortages, the red capsule was not readily available which would have put Leptin Resistance Rx on backorder for quite some time.

#2. We used this opportunity to cut down on any unnecessary fillers/dyes. Even though the old red capsule contained natural colorings, there were a small handful of people who reacted to it. Now, these people can take advantage of the new capsule and there are fewer ingredients to worry about.

Other than the color of the capsule, the ingredients are 100% the exact same.

If you are struggling with weight gain, the inability to lose weight, or just want help losing a couple of extra pounds then this supplement is ideal for you.

Almost every single overweight person has some degree of leptin resistance and when present, leptin resistance limits your ability to lose weight and keep it off.

By improving your leptin level you will help your body lose weight faster and keep it off longer.

You do NOT have to check your leptin level prior to using this supplement. Just being overweight is enough to know that you have some degree of leptin resistance.

Checking your level can help you determine how severe your leptin resistance is and can be useful, however.

Take 1-2 capsules per day, with or without food, while you are trying to lose weight.

The more severe your leptin resistance or the more weight that you want to lose you should take Leptin Resistance Rx for longer.

For more severe forms of leptin resistance, you should also consider adding additional supplements (guidelines above).

Yes! Leptin Resistance Rx can be used with my other supplements (and, in fact, works better this way) and it can be used with all types of thyroid medications.

The duration of therapy depends on how quickly you lose weight and how severe your leptin resistance is.

In general, it’s a good idea to use Leptin Resistance Rx throughout the duration of your weight loss phase and at least 1-2 months into your maintenance phase.

As long as you are trying to lose weight you should be taking it!

You should not experience negative side effects while using Leptin Resistance Rx.

As with all of my supplements, I try to use the smallest amount of inactive fillers.

In addition to the active ingredients, Leptin Resistance Rx contains the following:

  • HPMC (veggie capsules)
  • Microcrystalline cellulose
  • Nu-FLOW (Rice extract)

All domestic orders receive free shipping regardless of price. Orders are typically processed within 1 business day, they are shipped out via USPS Ground Advantage and typically arrive within 1-3 business days.

We also offer intentional shipping to most countries as well! International orders ship free if the order value is greater than $250 USD. Otherwise, the price of shipping is calculated on the checkout page. We primarily use USPS for international shipments.

All of my products come with a 60-day money-back guarantee. I’m confident that my products will work for you but, in case they don’t, for whatever reason, you can return them for a full refund within 60 days. It makes purchasing them a no-brainer!

You can find more information about our return and refund policy by clicking here.

Yep! Every single batch of supplements undergoes third-party testing for heavy metals, pathogens, ingredient profile, and purity. In addition, my products are produced in a GMP-compliant facility in the United States.

Don’t hesitate to reach out! Please email us at hello@restartmed.com and we will do our best to get back to you within a day or so! You can also call us here: (480) 331-9431.

Questions about our quality standards? Please see this article for more information.

Scientific References

#1. The effects of an oral preparation containing hyaluronic acid (Oralvisc®) on obese knee osteoarthritis patients determined by pain, function, bradykinin, leptin, inflammatory cytokines, and heavy water analyses: https://pubmed.ncbi.nlm.nih.gov/24899570/

#2. Short-Term Effect of a New Oral Sodium Hyaluronate Formulation on Knee Osteoarthritis: A Double-Blind, Randomized, Placebo-Controlled Clinical Trial: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564147/

#3. Synergistic Effects of a Mixture of Glycosaminoglycans to Inhibit Adipogenesis and Enhance Chondrocyte Features in Multipotent Cells: https://www.researchgate.net/publication/283791276_Synergistic_Effects_of_a_Mixture_of_Glycosaminoglycans_to_Inhibit_Adipogenesis_and_Enhance_Chondrocyte_Features_in_Multipotent_Cells

#4. Synergistic Effects of a Mixture of Glycosaminoglycans to Inhibit Adipogenesis and Enhance Chondrocyte Features in Multipotent Cells: https://www.karger.com/Article/Fulltext/438542

Additional information

Weight 0.25 lbs
Dimensions 2.5 × 2.5 × 5.0 in

30 Capsules, 60 Capsules

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

**Results may vary.

Customer Reviews

Based on 795 reviews
Melissa C.
Still losing weight

I’ve been using the weight loss bundle, eating healthy and trying to exercise and I’m down 17 pounds, which is unheard of for me… love the products!

Anna L.


Larissa C.
Knee pain relief

I am taking this for my knee pain relief. My Doctor suggested it. I have osteoarthritis in begginning stages and Type II diabetes. I don't know how, but it reduces my knee pain more than 80%. I know that it is the Oralvisc at work, because my pain returns after few days of stopping to take the supplement and goes away again when I resume taking it. Grateful for finding your product.

Felicia K.
Leptin Resistance

Love taking the Leptin with the Berberine. They are helping me lose weight. Thank you

hannelore c.
Leptin resistance

Seems to be helping. Have had 8 lb wt loss after 45 days

leptin resistance rx 60 count front bottle image 1500 x 1500
Leptin Resistance Rx | Leptin Sensitizer with ORALVISC & GAGs for Metabolic Support (60 Count)
$69.99 or subscribe and save 5%
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