Thyroid Leptin BalanceLeptin Sensitizer with ORALVISC & GAGs for Metabolic Support (60 Count)
$49.99 — or subscribe to save 10%
- Supports healthy leptin-thyroid signaling: Helps restore communication between your metabolism, hunger hormones, and thyroid pathways*[1][7][13]
- Promotes natural satiety and fullness: Assists your brain in registering true “fullness” so you naturally feel satisfied with smaller portions*[7][14]
- Helps maintain a steady metabolism: Supports healthy cellular energy production to help manage age-related metabolism slowdown and fatigue*[9][12]
- Powered by clinically studied Oralvisc® & IGOB131®: Provides trademarked ingredients that have been scientifically shown to support healthy leptin levels and metabolic health*[2][8]
Ingredients
- Oralvisc® specialized glycosaminoglycans, clinically studied for leptin cell signaling
- IGOB131® African mango extract for leptin sensitivity
- Broccophane® and Trans-Resveratrol for cellular detox and the thyroid axis
- BioPerine® and Vitamin C for metabolic support and absorption
Completely stimulant-free. See the research below.
How to use
Take 2 capsules each morning, with or without food. If using with thyroid medication, take it 30-60 minutes before or after. Works alongside GLP-1s and other weight loss formulas.
Shipping and returns
Free US shipping on every order, processed within 1 business day, arriving in 3 to 5 business days via USPS Ground Advantage. 60 day money-back guarantee: if it does not work for you, return it for a full refund. No questions asked.
Why the weight won’t budge
Stop blaming your willpower when it’s your hormones
When you have leptin resistance, your brain slows down your metabolism and increases your appetite. No matter how hard you try, you won’t be able to eat your way out of this problem.
Thyroid Leptin Balance is formulated to re-sensitize your cells to leptin, ‘waking up’ your metabolism and helping your body finally respond to the hard work you’re already putting in.*
Dr. Westin ChildsThyroid specialist and formulator
Your thyroid starts the cycle
A slow thyroid makes gaining weight easy and losing weight more difficult. As you gain weight, your fat cells make more and more leptin.[7][14]
Your body becomes resistant to leptin
High leptin leads to leptin resistance, which makes losing weight slower and even more difficult.[1][7][13]
Thyroid Leptin Balance supports your goals
Ingredients like ORALVISC and IGOB131 have been clinically studied for their ability to support leptin sensitivity.[2][8]*
What’s inside
Six clinically studied ingredients, four jobs
Every ingredient is research-backed and hand-picked for its support of leptin signaling, appetite, and metabolism – exactly what thyroid patients need.
The actual label, straight off the bottle. Click to enlarge.Oralvisc® specialized glycosaminoglycans
This trademarked ingredient provides support to the immune system, which has a powerful impact on leptin cell signaling.[1][5][6] In states of chronic inflammation from diet and stress, your fat cells become inflamed and damaged, leading to constant weight gain, a sluggish metabolism, and constant cravings.[7] Oralvisc is clinically studied to support and manage this effect.[2][3][4]
IGOB131® African mango extract
Leptin is the hormone created by your fat cells, and its job is to act as a messenger between your fat cells and your brain.[7][14] When you become resistant to leptin, your metabolism slows down and your appetite increases, making weight loss feel impossible. IGOB131® is clinically studied to help restore normal leptin sensitivity so you can start burning fat instead of storing it.[8]
Broccophane® & Resveratrol cellular detox & thyroid axis
You need healthy cells if you want to lose weight and keep it off. Why? Because inflammation puts heavy stress on your body, leading to hormone imbalances and weight loss resistance. The combination of Broccophane (advanced sulforaphane) with Trans-Resveratrol provides the antioxidants your cells need to protect your thyroid and hormone pathways, assist your body’s natural detoxification processes, and support your fat cells’ primary functions.[9][10][12]
BioPerine® & Vitamin C complete metabolic boost
Losing weight isn’t about calories; it’s about your hormones. When your hormones are imbalanced, you can eat fewer calories without losing weight. BioPerine and Vitamin C support thermogenic energy production, helping to maintain a steady metabolism, vitality, and natural appetite control.[7][14] BioPerine also serves as a bioavailability enhancer, making all of the ingredients in this formula work even better.[11]
Real-world patient outcomes
What thyroid patients actually report
Pulled from verified reviews and the published Patient Outcomes Report for this formula, not from a study we paid for.
“I am a 70 year old who had tried unsuccessfully for months to lose weight. After starting the Thyroid Leptin Balance about a month ago I have lost 7 pounds. Very happy with this result and intend to purchase it again.”
Less hungry
This definitely makes me less hungry. I see a difference when I forget to take it. Highly recommend. No side effects.
Appetite control
I LOVE THIS PRODUCT. I would recommend it to anyone that needs a little extra help with appetite control.
Second bottle
This is my second bottle and I do notice how this suppressed my appetite and cravings.
Almost 30 lbs down
I think this is my 4th or 5th refill of leptin resistance. With a combination of balanced thyroid levels, managing stress, exercise, and diet I have lost almost 30 lbs since June 2022. I will continue to use this along with my other tools.
58 lbs in 3 months
I had my Labs ran to include my Leptin levels. Mine were very high. I was told I needed to have mine lower asap and it would help me naturally lose weight. Within 3 months I lost 58 lbs.
Menopause weight
Menopause gifted me 20 extra pounds that I couldn’t lose. After taking Leptin for a month I began to lose weight. Now about a year later I have lost 10 to 12 pounds and it has stayed off. I feel more energetic. I am 77 and weigh 120.
Read the full Patient Outcomes Report
Frequently bought together
Patients often pair it with these
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$53.99 — or subscribe to save 10%Berberine 500+Dihydroberberine Weight Loss Formula (60 Servings)Subscribe & Save 10%Shop NowFree US Shipping -
$44.99 — or subscribe to save 10%Thyroid Fat BurnerThermogenic Weight Loss Supplement (30 Servings)400+ bought in past monthSubscribe & Save 10%Shop NowFree US Shipping
Your new schedule
Two capsules, every morning
- 1Take 2 capsules each morningWith or without food.
- 2Space it from your thyroid medicationIf using with thyroid medication, take it 30-60 minutes before or after.
- 3Stay consistentLeptin and thyroid take weeks to respond, not days. The subscription exists so you never break the streak.
What to expect
The earliest changes
Subtle at first. This is when most people start to notice fewer cravings, less “food noise”, and a more balanced appetite.
Metabolic changes show
You may start to notice changes in how your clothes are fitting, changes in your measurements, and the scale starting to move downward.
Results compound
With consistent daily use, your body continues to respond as you become more sensitive to leptin. Judge it by your measurements and how your clothes fit.
How it compares
See how Thyroid Leptin Balance compares
| Thyroid Leptin Balance | Other weight loss supplements | GLP-1 medications (Rx) | Regular supplements | |
|---|---|---|---|---|
| Made for thyroid patients | ✓ | ✕ | ✕ | ✕ |
| Targets leptin resistance | ✓ | ? | ✕ | ✕ |
| Stimulant-free | ✓ | ? | ✓ | ? |
| Created by a thyroid expert | ✓ | ? | ✕ | ✕ |
| Clinically studied ingredients | ✓ | ? | ✓ | ? |
| Usable with thyroid meds | ✓ | ? | ✓ | ? |
| No injections | ✓ | ✓ | ✕ | ✓ |
| Available without prescription | ✓ | ✓ | ✕ | ✓ |
| 60 day money-back guarantee | ✓ | ✕ | ✕ | ✕ |
Frequently Asked Questions
Can I take Thyroid Leptin Balance if I’m already on prescription thyroid medication?
Yes! Thyroid Leptin Balance can be used with all thyroid medications.
For best results, make sure to use this 30-60 minutes away from whenever you take your thyroid meds.
What’s the difference between Thyroid Leptin Balance and Leptin Resistance Rx?
You can think of Thyroid Leptin Balance as the upgraded, more complete version of Leptin Resistance Rx.
The original formula (Leptin Resistance Rx) was built around two ingredients: ORALVISC and vitamin C.
Thyroid Leptin Balance includes these ingredients, but adds four more clinically studied ingredients: IGOB131 (African mango), trans-resveratrol, Broccophane, and BioPerine.
Together, they more completely address leptin resistance in thyroid patients, giving you a more powerful formula.
Can I take this if I’m on a GLP-1 agonist like Ozempic or Zepbound?
Yes! Thyroid Leptin Balance is safe to use with GLP-1 agonists like Ozempic, Wegovy, Zepbound, and Mounjaro.
They actually work very well together. Your GLP-1 supports appetite and blood sugar, while this formula helps with the hormone side of the equation (leptin and thyroid).
Does this formula contain caffeine or stimulants?
No! Thyroid Leptin Balance is completely stimulant-free.
It works by supporting your hormones (thyroid and leptin) and appetite, not by overstimulating your metabolism or adrenals, so you won’t get the jitters or afternoon crash that comes with caffeine and other stimulants.
You can also take it at any time of the day.
Are there any known side effects or digestive issues with these ingredients?
No, side effects are very uncommon with Thyroid Leptin Balance.
The formula was designed specifically for thyroid patients, so it’s gentle but powerful. And because it’s stimulant-free, you won’t experience jitters or a crash when using it.
If you have a sensitive stomach, just be sure to take it with food, and you will be good to go.
How soon can I expect to notice changes?
Every thyroid patient is unique and a little bit different, but here’s the general timeline of what to expect and when:
Weeks 1-2: The earliest changes will be subtle, but here is when most people start to notice fewer cravings, less “food noise”, and a more balanced appetite.
Weeks 4-6: This is when the metabolic changes start to show (remember leptin and thyroid take weeks to respond, not days). You may start to notice changes in how your clothes are fitting, changes in your measurements, and the scale starting to move downward.
Weeks 12+: With consistent daily use, this is where your results start to add up and compound. Your body will continue to respond as you become more sensitive to leptin, which means more obvious and noticeable changes to appetite, metabolism, weight loss, and body shape.
Just remember that healthy weight loss is a slow and steady process, but if you do it this way, your results will stick!
Do I need to follow a strict diet for this supplement to work?
No, you don’t need to follow a strict or restrictive diet for this to work.
Remember:
Weight loss isn’t only about counting calories for thyroid patients; it’s more about balancing your hormones.
Thyroid Leptin Balance helps with the hormone side, which is what makes your weight loss feel easier and “stickier”.
All that said, I strongly recommend that you combine this supplement with two things:
#1. A thyroid-safe fasting protocol (100 total hours per month, split up however you prefer).
#2. A thyroid-approved whole food-based diet.
You can find more information on fasting here and more information on my recommended diet here.
If you combine this all together, you will create an incredibly powerful weight loss routine which will work for about 98% of people (you just need to add in exercise to round it off).
How do I know if the formula is working if the scale isn’t moving right away?
This is one that confuses a lot of people, so allow me to explain:
The scale is actually one of the worst ways to measure weight loss if you have a thyroid problem or leptin resistance, especially early on.
Why? Because these conditions cause inflammation, fluid retention, stool retention, and lymphatic congestion. And all of these will add extra weight to the scale that is NOT fat.
In addition, when you lose weight the right way, your body will simultaneously build muscle while it burns fat. Since muscle is more dense than fat, the scale often stays steady, even when your body is physically changing, and you are losing weight.
The most accurate way to measure weight loss with thyroid and leptin problems is with body measurements. If you see your measurements shrinking (or your clothes fitting differently), then you know your body is losing fat.
Another method is to take pictures every 1-2 weeks and compare your body over a period of 2-3 months.
How long should I stay on this formula to maintain my results?
The short answer: for as long as you’re actively trying to lose weight.
Once you hit your weight loss goal, I recommend staying on it for another 1-2 months to make sure your results are “sticky”.
After that, it’s up to you. Because thyroid patients are prone to leptin resistance, many choose to stay on it long term to help maintain their appetite and metabolism, but it’s not required.
Can I safely combine this with other weight loss supplements?
Absolutely! Thyroid Leptin Balance contains ingredients that you won’t find in other weight loss supplements, so there is no risk of overlap or doubling up.
That means it can safely be combined with our other weight loss formulas like Berberine 500+ and Thyroid Fat Burner.
In fact, it’s even better if you stack this supplement with those for better synergy and results.
What makes this formula worth the price?
Thyroid Leptin Balance is built around trademarked, clinically studied ingredients like ORALVISC and IGOB131 that you won’t find in other supplements. These are specialized ingredients that have been proven in research studies to do what they say they do.
On top of that, every batch is third-party tested for purity and made in an NSF GMP-compliant facility in the United States.
In short, you get specialized ingredients at efficacious doses with a 60-day money-back guarantee.
What fasting schedule works best when using this?
Fasting is the best way to handle the “calorie” side of the equation when it comes to weight loss with thyroid and leptin problems.
My recommendation is to get a total of 100 hours of fasting each month.
This will naturally reduce your calories for those days without causing harm to your thyroid or hormones.
You can choose to split this up however you want, but I find that one 24-hour fast each week is the most effective way to do this.
24 hours of fasting x 4 days per month = 96 total hours of fasting.
What is ORALVISC?
ORALVISC is one of the star ingredients in Thyroid Leptin Balance.
It’s a trademarked, proprietary blend made up of roughly 70% hyaluronic acid and glycosaminoglycans.
I chose this because it’s one of the few ingredients that has been shown to impact body weight, inflammation, and leptin levels in animal and human studies.
It has a complicated mechanism of action, but the short version is that it helps calm immune signaling and reduce cellular inflammation, which in turn helps improve your body’s leptin sensitivity.
The more sensitive you are to leptin, the easier it is to lose weight and keep it off.
Will this help with my leptin level?
Yes! That is the whole point of this formula.
If you have leptin resistance, your leptin level is usually high because your body has stopped responding to it. By improving your leptin sensitivity, your body is better able to respond to leptin again, which allows those high levels to come back down to normal.
In short, your brain is better able to receive the message that your fat cells are sending to it.
How do I know if I have leptin resistance?
Contrary to popular belief, you don’t need fancy lab tests to tell:
If you’re overweight and struggling to lose weight, you almost certainly have some degree of leptin resistance.
And it’s especially common in thyroid patients because of how thyroid hormone impacts leptin sensitivity.[13]
Some of the biggest signs are constant hunger and cravings for food, trouble losing weight no matter what you try or do, and carrying extra weight in your belly or midsection.
Testing for your leptin level is not required to use this supplement, but you can use leptin testing to assess the severity of your leptin resistance.
The higher your leptin level, the more resistant you are.
Can Thyroid Leptin Balance be taken while fasting?
Yes! Thyroid Leptin Balance can be used while fasting, and taking it will not break your fast.
It does not contain any calories, sugar, or stimulants, so you can take it at any time of the day.
And since fasting also helps improve your leptin sensitivity, using them together is a great combination.
Can this product be shipped to Canada?
Unfortunately, no. We are not able to ship Thyroid Leptin Balance to Canada.
The reason is that it contains ORALVISC, which is classified as a pharmaceutical in Canada.
While we can’t ship it to Canada, we can ship it to all 50 states in the US, along with most other countries.
What is your Return/Refund Policy?
All of my products come with a 60-day money-back guarantee. I’m confident that my products will work for you but, in case they don’t, for whatever reason, you can return them for a full refund within 60 days. It makes purchasing them a no-brainer!
You can find more information about our return and refund policy by clicking here.
Are your supplements regulated for quality?
Yep! Every single batch of supplements undergoes third-party testing for heavy metals, pathogens, ingredient profile, and purity. In addition, my products are produced in an NSF GMP-certified facility in the United States.
What if I have other questions?
Don’t hesitate to reach out! Please email us at hello@restartmed.com and we will do our best to get back to you within a day or so! You can also call us here: (480) 331-9431.
Questions about our quality standards? Please see this article for more information.
Buying with confidence
If it doesn’t work, you don’t pay for it
60 day money-back guarantee
Return it within 60 days for a full refund. No questions asked and no hoops to jump through.
Third-party tested, every lot
Made in the USA in an FDA-registered, NSF-certified GMP facility, and every lot is tested by an ISO-accredited lab for heavy metals, pathogens, bacteria, mold and yeast. See the results
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Thyroid Leptin Balance
$49.99 or $44.99 with subscribe and save. 60 count bottle.
Scientific References
View All References
1. Childs, W. (2026). Overcoming Leptin Resistance in Thyroid Dysfunction: A Formulation Rationale and Consumer Case Series Utilizing High-Molecular-Weight Glycosaminoglycans. Restart Medical LLC.
2. Nelson, F.R., et al. (2015). The effects of an oral preparation containing hyaluronic acid (Oralvisc) on obese knee osteoarthritis patients determined by pain, function, bradykinin, leptin, inflammatory cytokines, and heavy water analyses. Rheumatology International. doi:10.1007/s00296-014-3047-6.
3. Cicero, A.F.G., et al. (2020). Short-Term Effect of a New Oral Sodium Hyaluronate Formulation on Knee Osteoarthritis: A Double-Blind, Randomized, Placebo-Controlled Clinical Trial. Diseases. doi:10.3390/diseases8030026.
4. Petrov, P., et al. (2015). Synergistic Effects of a Mixture of Glycosaminoglycans to Inhibit Adipogenesis and Enhance Chondrocyte Features in Multipotent Cells. Cellular Physiology and Biochemistry. doi:10.1159/000438542.
5. Taylor, K.R., et al. (2006). Glycosaminoglycans and their proteoglycans: host-associated molecular patterns for initiation and modulation of inflammation. The FASEB Journal. doi:10.1096/fj.05-4682rev.
6. Kim, Y., et al. (2020). The Role of Hyaluronan Treatment in Intestinal Innate Host Defense. Frontiers in Immunology. doi:10.3389/fimmu.2020.00569.
7. Gomez, W.A., et al. (2025). Leptin Signaling and Its Relationship with Obesity-induced Insulin Resistance: A Bioinformatics-assisted Review. Gene Expression. doi:10.14218/GE.2024.00039.
8. Ngondi, J.L., et al. (2009). IGOB131, a novel seed extract of the West African plant Irvingia gabonensis, significantly reduces body weight and improves metabolic parameters in overweight humans in a randomized double-blind placebo controlled investigation. Lipids in Health and Disease. doi:10.1186/1476-511X-8-7.
9. Timmers, S., et al. (2011). Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans. Cell Metabolism. doi:10.1016/j.cmet.2011.10.002.
10. Çakır, I., et al. (2022). Sulforaphane reduces obesity by reversing leptin resistance. eLife. doi:10.7554/eLife.67368.
11. Shoba, G., et al. (1998). Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Medica. doi:10.1055/s-2006-957450.
12. Axelsson, A.S., et al. (2017). Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes. Science Translational Medicine. doi:10.1126/scitranslmed.aah4477.
13. Duntas, L.H., et al. (2013). The interconnections between obesity, thyroid function, and autoimmunity: the multifold role of leptin. Thyroid. doi:10.1089/thy.2011.0499.
14. Klok, M.D., et al. (2007). The role of leptin and ghrelin in the regulation of food intake and body weight in humans: a review. Obesity Reviews. doi:10.1111/j.1467-789X.2006.00270.x.
Additional information
| Weight | 0.25 lbs |
|---|---|
| Dimensions | 2.5 × 2.5 × 5.0 in |
| Size | 30 Capsules, 60 Capsules |
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
**Results may vary.
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