Berberine 500+ | Dihydroberberine Complex For Weight Loss

Berberine 500+ | Dihydroberberine Weight Loss Formula (60 Servings)

$53.99 or subscribe and save 5%

Berberine 500+ is a research-backed, physician-formulated, weight loss-promoting supplement that provides you with the most powerful and bioavailable form of berberine (as dihydroberberine) which is combined with alpha lipoic acid, Ceylon cinnamon, and chromium to help you lose weight, balance your hormones, improve gut health, normalize cholesterol levels, and balance blood sugar.*

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Manufactured in The USA

Third-party tested for purity

60-day Money Back Guarantee


Will taking Berberine 500+ help you melt off body fat while simultaneously allowing you to increase your muscle mass and metabolism without any other work on your part?

Definitely not!

But it is a well-researched and well-formulated dietary supplement that can help you more easily lose weight, build muscle mass, and balance your hormones if combined with lifestyle changes like intermittent fasting, eating a whole food diet, and exercising regularly.

And when you purchase any supplement from Dr. Westin Childs you get the added benefit of knowing:

  • Every single supplement is third-party tested by an ISO-accredited lab for purity, contaminants, microbes, mold, and heavy metals.
  • Total transparency is the standard when it comes to reviews and opinions from people who have used our supplements (we have a 99% transparency medal from our third-party review aggregator
  • All of my supplements are made in an FDA-inspected and GMP-compliant facility.


This plant-derived isoquinoline alkaloid activates a powerful enzyme known as AMP kinase, the same enzyme that is activated during exercise and when taking certain medications like metformin.

And it is the activation of this enzyme that provides the majority of the benefits associated with berberine use including weight loss, blood sugar control, and lower cholesterol. 

Berberine 500+ has been formulated with a downstream derivative known as dihydroberberine which has been shown to be up to 5x more bioavailable than standard berberine. 

This means you get better results at lower dosages with reduced risk of side effects. 

Research shows that berberine can…

  • Help you lose weight*
  • Improve insulin sensitivity*
  • Lower cholesterol*
  • Increase fatty acid oxidation*
  • Improve gut health*
  • Increase mitochondrial density in skeletal muscle*
  • Activate brown fat*
  • Act as an anti-inflammatory agent*

…making berberine a no-brainer for anyone seeking to lose weight.

This plant-derived short-chain fatty acid acts as an incredibly powerful antioxidant making it an effective treatment against oxidative-stress-associated diseases and conditions.

It works by neutralizing free radicals and regenerating other antioxidant factors such as vitamin C and vitamin E which act to increase glutathione synthesis.

Because of these effects, research has shown that alpha lipoic acid can…

  • Reduce body weight and fat mass*
  • Decrease appetite and food intake*
  • Enhance energy expenditure*
  • Act as an anti-inflammatory agent*
  • Improve insulin sensitivity*
  • Improve nerve health
  • Prevent vascular damage*

…making it the perfect complementary ingredient to berberine for weight loss.

As a spice, cinnamon has gained notoriety not only for its delicious flavor but also for its ability to combat weight gain.

Research has shown that cinnamon has…

  • Weight loss promoting properties*
  • Blood sugar lowering properties*
  • Cholesterol-lowering properties*
  • Antioxidant properties*
  • Anti-inflammatory properties*

When it comes to the choice of cinnamon, Ceylon cinnamon (or “true cinnamon”) reigns supreme.

Compared to the more commonly used Saigon cinnamon, Ceylon cinnamon has more research supporting its use and contains lower levels of a toxic compound known as coumarin, making it a clear winner between the two.

Owing to cinnamon’s complementary effects on weight loss, blood sugar control, and its action as an anti-oxidant, it’s the perfect complementary ingredient to dihydroberberine and alpha lipoic acid.

Chromium is an essential trace element that the body uses to break down carbohydrates, protein, and fat.

It also happens to be a nutrient that many people are not getting enough of.

As a result, research has shown that supplementation with chromium…

  • Increases lean body mass and decrease body fat*
  • Enhances blood sugar and insulin sensitivity*
  • Normalizes total cholesterol, LDL, and apolipoprotein B*

There is some debate as to whether or not isolated chromium supplementation helps with weight loss when used alone but that doesn’t matter for Berberine 500+ because its inclusion is to provide synergistic support for the other more powerful ingredients.

Dr westin childs photo

Why Dr. Childs Recommends It

“Berberine and alpha lipoic acid are probably two of my favorite ingredients for weight loss because they target unique pathways, they are very effective, and hardly anyone knows about them.

Berberine has the potential to do two very important things: help you build muscle mass and lose fat mass while also balancing fat-storing hormones like insulin. It’s a great option for anyone trying to lose weight.”

Used by over 80,000+ people who have left over 10,000+ reviews

Ingredients That Work

Ingredients and dosages are thoughtfully chosen, relentlessly tested, and continually refined.

Physician Formulated

All formulas have been created by Dr. Westin Childs based on his clinical experience and evaluation of peer-reviewed scientific research.

Made in the USA

Our supplements are proudly made in the USA, with globally sourced ingredients, in a GMP-compliant facility and shipped from Mesa, Arizona.  

Third-Party Tested

Every single supplement lot is third-party tested for heavy metals, microbes, mold, and contaminants by an ISO-accredited lab testing facility.

Free Domestic Shipping

Every order (regardless of price) placed in the U.S.A. will ship free with USPS.

60-Day Money Back Guarantee

If you don’t love your supplements then you can return them for a full refund! No questions asked and no hoops to jump through. 

Frequently Asked Questions

Berberine 500+ has been reformulated with a new more powerful and bioavailable compound known as dihydroberberine.

Research shows that this version of berberine is absorbed at a rate of roughly 5x berberine HCL.

Given the 5x increase in bioavailability of dihydroberberine, the newly reformulated Berberine 500+ is now twice as powerful as the old version.

Not only is it more powerful, it is also better tolerated.

This means fewer side effects, more power, and better results.

In addition, each dose of Berberine 500+ now contains 250 mg of Ceylon cinnamon for more weight loss, insulin-lowering, and blood sugar-controlling effects.

If you loved the old version of Berberine 500+ then you are going to love this new version even more!

Yes, but perhaps a better way to state how it works is to say that it supports your existing weight loss efforts and makes those efforts more effective.

Berberine 500+ will put your body into a state where weight loss is more effective and easier, but it is unlikely to cause weight loss without any other effort or input on your part.

For this reason, you should always combine Berberine 500+ (or any of my other weight loss supplements) with things like a whole-food diet, regular exercise, and intermittent fasting.

Using my weight loss supplements in this way will make your efforts far more effective and help you obtain your goals.

That is a great question!

If you want to lose weight, keep it off, and change your body into a well-oiled fat-burning machine then you need to be doing more than just taking supplements.

Yes, supplements can absolutely help, but they don’t replace important lifestyle changes like diet and exercise.

No matter what you are doing, these need to be done as well.

Based on my extensive research in helping patients with weight loss, here’s what works best when using Berberine 500+:

  • A whole food diet (I’ve seen just about every single one work including the ketogenic diet, carnivore diet, low carb, vegan, whole30, etc. Just make sure to find a whole food diet that works for you).
  • Regular exercise at least 3-5 times per week. My preference is weight lifting as it helps with weight loss and building muscle mass but pretty much anything can work here. If cycling is your thing then go for that. If you prefer pilates or yoga or something less intense, more power to you. What you do is less important than making sure you do it consistently.
  • Intermittent fasting. If you are overweight then going for several hours to even a full day without food is incredibly helpful for balancing fat-storing hormones like leptin and insulin. My favorite fasting protocols include 2, 24-hour fasts each week, one meal a day, every other day fasting, or 16-hour fasting windows (see more information below).

Fasting is simply going without food for a set period of time and it’s been a regular part of cultures and religions for thousands of years.

Taking advantage of fasting as a therapy allows you to get more benefits out of weight loss therapies including supplements, medications, and even exercise.

If you are new to fasting, here are several protocols that can be considered (I’ve seen them all work):

  • 2, 24-hour fasts each week: This fasting protocol is easy, you just take 2 days out of the week and you go without food for a 24-hour period.
  • Every other day fasting (3, 24-hour fasts each week): Every other day fasting is very similar but you can pick whatever 3 days work best for you based on your schedule. Most people who use this method do 1, 24 hour fast on Monday then again on Wednesday then again on Friday.
  • OMAD (one meal a day): One meal a day is exactly as it sounds, you eat one gigantic meal each day.
  • 16-hour fasting windows: This is similar to the one meal-a-day plan but it allows you to eat for an 8-hour window (as opposed to just one meal) every day. This means that each day you will be fasting for at least 16 hours. This is an easier way to jump into fasting if some of the other options seem too intense for you.

Don’t be afraid to play around with these fasting protocols to find something that works best for your body and your situation!

No matter what you do, just make sure you are doing some form of fasting if you are trying to lose weight!

For best results take 2 capsules of berberine 500+ in the morning and 2 capsules in the evening with or without food.

If you take thyroid medication take this supplement 30-60 minutes away from your thyroid medication.

How quickly you see results depends on how you are checking for those results and factors including how resistant you are to weight loss.

Most people, however, should expect to see changes after about 4-6 weeks of daily consistent use.

This is because it takes time for the active ingredients to build up in your system and exert an impact on hormones (like insulin) and your muscle mass.

Don’t be alarmed with this timing, though, because it’s perfectly normal for any therapy that actually helps you lose weight the right way to take about this long.

If you are undergoing any weight loss therapy which purports to help you lose weight rapidly it will always come at a cost to your metabolic health.

Safe and effective weight loss, on the other hand, allows you to lose weight and keep it off while also improving your overall health.


You aren’t losing weight to get healthy, you are getting healthy to lose weight and this process takes time.

When you are losing weight in a safe and effective way the best way to measure your success is not the scale!

Here’s why:

The scale is a measurement of your total body mass which takes into account many factors including your fat mass, your muscle mass, and your water weight.

What most people who need to lose weight fail to understand is that obesity causes a combination of two things:

A decline in muscle mass and a rise in fat mass.

When you start losing weight correctly, your body will naturally build muscle mass while burning fat mass simultaneously.

When this occurs the scale stays the same (at least initially) and this is perfectly normal!

It’s actually a good thing, too, because muscle mass is much more metabolically active and will help you lose more weight down the road.

At some point, your muscles will reach a steady state and they will no longer grow (unless you are specifically focused on them with strength training).

When this happens, you will start to see the scale move downward.

This process takes around 4-6 weeks which is why using the scale for the first 1-2 months is a very poor metric of your success.

A better tool to assess whether or not what you are doing is working is to use body measurements.

You’ve probably heard the adage that muscle is heavier than fat, right? Even though your total weight will stay the same initially, the size of your body will shrink.

Body measurements provide a safe and easy tool to assess for body fat loss while also taking into account the building of muscle mass.

For best results, take the following measurements when you start and periodically (every 1-2 weeks) as needed:

  • Hips: Find the widest part of your glutes and take the measurement.
  • Chest: Find the widest part of your chest and take the measurement (be mindful of your menstrual cycle which can impact your breast size)
  • Thighs: Find the midpoint between the lower glutes and the back of the knee, and take your measurement here.
  • Waist: Find the narrowest part of your natural waist and take your measurement.
  • Arms: Find the midpoint between your shoulder bone and the elbow of your arm. Take the measurement here.

Berberine 500+ is designed to be taken indefinitely so I recommend using it as long as you need it!

For most people, that will be as long as they are trying to lose weight but it can also be used daily to help with things like blood sugar levels, building muscle mass, and for anti-aging purposes.

You have a couple of different options!

For starters, I would recommend checking out the reviews on all of my products.

I feel transparency is very important to the health of a business and for patient expectations which is why we do not hide or delete reviews.

In other words, you can trust our reviews.

In addition to the reviews, you can also check out some case studies of real patients who have used my weight loss treatments with success.

Here are several that you can check out:

The links above will walk you through everything these patients used to lose weight and keep it off including what type of diet they used, the supplements they took, the medications and hormones that they needed, and much more.

I’ve also included a lot of additional information including how to use hormones, therapies, and other supplements to help with weight loss in my 60-day weight loss program.

My 60-day weight loss program is found inside my weight loss supplement bundle.


You can combine Berberine 500+ with other weight loss supplements or prescription weight loss medications.


Even though they both target insulin resistance, it’s still great to use them together.

Here’s why:

Using berberine with metformin may allow you to keep your dose of performing lower which will reduce negative side effects.

Even though they both target insulin levels, they are working via different mechanisms so you don’t run the risk of competition in that way.

It’s also highly unlikely that the combination will result in low blood sugar (I’ve never seen this happen before).

Berberine 500+ will not break your fast so it is safe to take it while you are in the middle of your fast.

Yes! If you are feeling like you need more assistance then I have multiple resources that can help.

If you want something to help guide you through the weight loss process then my 60-day weight loss program would be a great option.

It contains meal plans, medication guides, a supplement guide, a detox guide, and much more.

It’s built into my weight loss supplement support bundle at no extra charge.

If you are looking for some free information just so you can learn more then I would recommend checking out the many articles I’ve written and videos I’ve produced on the topic of weight loss.

You shouldn’t experience any negative symptoms while taking Berberine 500+. Having said that, sometimes berberine can be a little bit hard on the stomach if it’s taken without food.

If you are experiencing any issues, such as nausea, make sure you take it with food and that should solve the issue!

There is one study that everyone cites that showed that lipoic acid may reduce T4 to T3 conversion. What people don’t often realize is that this study was done in an experimental model of hyperthyroidism so it says nothing about the effects of lipoic acid on hypothyroid states.

In addition, there are far more studies that show that alpha lipoic acid has a positive effect on thyroid function and when all of the research is combined, there are far more net positive studies than negative.

In addition, it’s been my experience that thyroid patients do very well on alpha lipoic acid.

To date, berberine 500+ has been used on thousands of thyroid patients and we have yet to see any issues in T3 levels or thyroid function so this issue appears purely theoretical.

This product does NOT contain Wheat, gluten, yeast, soy, dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organisms, artificial colors, artificial sweeteners, or artificial preservatives.

All domestic orders receive free shipping regardless of price. Orders are typically processed within 1 business day, they are shipped out via USPS Ground Advantage and typically arrive within 1-3 business days.

We also offer intentional shipping to most countries as well! International orders ship free if the order value is greater than $250 USD. Otherwise, the price of shipping is calculated on the checkout page. We primarily use USPS for international shipments.

All of my products come with a 60-day money-back guarantee. I’m confident that my products will work for you but, in case they don’t, for whatever reason, you can return them for a full refund within 60 days. It makes purchasing them a no-brainer!

You can find more information about our return and refund policy by clicking here.

Yep! Every single batch of supplements undergoes third-party testing for heavy metals, pathogens, ingredient profile, and purity. In addition, my products are produced in a GMP-compliant facility in the United States.

Don’t hesitate to reach out! Please email us at and we will do our best to get back to you within a day or so! You can also call us here: (480) 331-9431.

Questions about our quality standards? Please see this article for more information.

Scientific References

























Additional information

Weight 0.25 lbs
Dimensions 2.5 × 2.5 × 5 in

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

**Results may vary.

Customer Reviews

Based on 592 reviews
Kay A.
Dramatic fat loss

Berberine 500+ is apparently what my body was missing. I stopped sugar and grains over 2 1/2 years ago. I have been intermittent fasting 16 hours for almost two years. I have been walking consistently at least 4 miles daily. All of these things were necessary due to a traumatic brain injury. My weight loss was 30 lbs but the body fat was still far above what my normal body should be. After three bottles of Berberine 500+ (mostly taken just two per day) my body fat dropped by over 20%. I did start Pilates Reformer classes three months ago and it helps dramatically with flexibility and toning. I am incredibly grateful. Visceral fat is dangerous to our organs. Last weekend I hiked 22,000 steps and felt energized! Thank you Dr. Childs. I look forward to the product being back in stock in a couple of days.

Lisa M.
Works for me!

Almost finished with my first order and have lost 7 pounds and LDL Cholesterol levels have reduced 21 points. Slow and steady wins the race!

Deborah T.
Berberine is Working

I've been on Berberine for 2 months and am starting to see improvements! Be patient:-)

Rebecca R.

I switched to this formula from the other formula. I haven't really noticed a difference, but I haven't gained weight either, so maybe it's helping.

Berberine 500+

Giving this Berberine 500 a 3 star as I have only been using it for a month, so far I have not witnessed any physical changes.

berberine 500+ front bottle image 1500 x 1500 (updated)
Berberine 500+ | Dihydroberberine Weight Loss Formula (60 Servings)
$53.99 or subscribe and save 5%
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