- T2 (diiodothyronine) is a thyroid hormone that your healthy thyroid gland naturally produces but is completely absent from standard thyroid medications like levothyroxine and Synthroid.
- T2 plays a critical role in mitochondrial function and fat burning that T4 and T3 alone do not fully replicate, which may explain why some patients still feel unwell on standard medication.
- Unlike T3, T2 does not significantly affect TSH or cause the heart-related side effects that make doctors cautious about prescribing T3, making it a safer supplemental option.
- NDT medications like Armour Thyroid contain small amounts of T2, which may partially explain why some patients feel better on NDT compared to synthetic T4-only medication.
- T2 supplements are available without a prescription and can be added to your existing thyroid medication regimen to address the metabolic gap left by T4-only or T4+T3 therapies.
Persistent Symptoms Despite Normal Thyroid Labs
She was doing everything right.
She took her thyroid medication, as instructed. She cleaned up her diet (cutting out processed food & sugar). She even added every recommended supplement she could find from gurus and influencers.
And yet… nothing changed.
She was still tired all of the time. Her weight wouldn’t go down. Her hair was still thinning. And her brain felt like it was wrapped in fog all day long.
When Lab Results Do Not Explain How You Feel
“Everything looks fine. Your thyroid labs are normal.”
But she knew her body. She knew something was off. And she was tired of being dismissed.
So she did what most thyroid patients aren’t expected to do:
She started digging.
Learning About T2 Thyroid Hormone
She came across something that none of her doctors ever mentioned:
A lesser-known thyroid hormone called T2.
T2 isn’t measured on standard thyroid lab tests, and it isn’t included in standard thyroid medications.
And most doctors haven’t been trained on what it is or what it does.
But here’s what the research says:
T2 plays a critical role in metabolism [1], energy, fat-burning [2], and mitochondrial function [3].
In fact, it also helps other thyroid hormones, like T3 and T4, do their job.
So while her labs looked “normal”, her body was starving for complete and healthy thyroid function at the cellular level.
Her Experience With T2 Supplementation
After adding T2 into her daily routine, everything began to shift.
She started to have more energy. And that energy became more stable.
Her brain fog started to lift. She felt like she could hold a conversation.
The scale even started to move down, slowly but surely, for the first time in years.
And this all happened without extreme dieting and without thyroid medication adjustments.
It was as if she was back to her normal pre-thyroid self again. For the first time in over a decade.
What Is T2 Thyroid Hormone?
- T2 is a naturally occurring thyroid hormone your body makes in small amounts.
- It’s not available in thyroid medications like Synthroid or levothyroxine.
- It’s the only thyroid hormone available over the counter (which means you don’t need a prescription to get it).
- And despite its importance, it’s been almost completely ignored by conventional doctors for years.
But thousands of thyroid patients are now using targeted T2 support to help their bodies and thyroid function the way it was meant to. And as a result, they are taking control of their thyroid.
What Is Essential T2?
Doctor-formulated. Research-backed. 100% non-prescription.
Essential T2 is a thyroid support formula designed to provide you with 100% bio-identical T2 thyroid hormone. The exact hormone that your medication is missing.
To date, it’s been used by thousands of thyroid patients (with or without thyroid medication) to help:
- Support healthy metabolism
- Enhance energy and mental clarity
- Promote fat-burning and mitochondrial function
- Improve thyroid hormone conversion & stabilize T4 and T3 levels
- Support healthy cholesterol levels
No fillers. No junk. Just the thyroid support that you’ve been missing.
How to Get Started With Essential T2
If you’ve been told that “everything looks normal”…
If you’ve done all of the right things but still feel off..
If you’re tired of wasting your money on treatments that don’t work…
Then T2 might be the missing piece of your thyroid puzzle.
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“This was the missing link!”
“I have been hypothyroid for many years and was doing okay on NP Thyroid until the fatigue and weight gain started creeping back. My doctor adjusted my meds based on labs, and it helped a bit, but I still wasn’t back to feeling like myself.
I tried T2 about 10 weeks after my last med adjustment and that’s when things finally changed. Around the 6–7 week mark, I noticed more energy, more motivation, and that things I used to dread felt easy again. I’m loving exercise again and feel like I’m back to my real self. I didn’t even realize how far I’d drifted until I came back. I LOVE this product. It was the missing link in my treatment.”
— Amy C. | July 2025
Click here to try Essential T2 now.
(Backed by our 100% 60-day guarantee)
What Thousands of Thyroid Patients Are Saying About Essential T2
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“I started taking this in mid May. After 6 weeks my tsh dropped from almost 3 to .91! My energy has skyrocketed and I am feeling so much better. I take t4 only meds, and obviously this is the missing link. I will continue to purchase again and again. Thank you for the information and the great product!“
— Randi N.
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“…Sugar cravings are way down and I feel more energy and fuller after smaller meals!! I wrote this before doing labs – but I don’t even really care what they come back as – I feel so much better.
But I suspect my labs will be good. I’ll update if issues.
I can’t be more Thankful for Dr Child’s and T2!!”
— Tammy R.
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“I am feeling great, this bundle is doing so well for me, not needing to take prescription drugs. I would highly recommend anyone to give it a try, it made me a believer. Yes, I will continue ordering.
— Cheri W.
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“3rd Day on …..May have to take every few days 100 MCG
“Wow ……my basal metabolic rate has skyrocketed. After 3 doses. I think it is helping with blood sugar regulating too ((been having issues there side effects of keto/carnivore)). But man o man THIS stuff is powerful. NEVER experienced anything like this on natural dessiacted thyroid in 17 YEARS on it….”
— Ruth N.
Want to see more? Click here to see 1,000+ reviews from thyroid patients just like you.
Learn More About T2 and Thyroid Health
If you want a deeper dive into how T2 works and why it’s been overlooked by conventional medicine, check out these resources:
- T2 Supplement Benefits (How it works & what it does in your body)
- T2 Safety & Side Effects (Is it really safe?)
- T2 In Thyroid Medications (How much is there?)
- Using T2 for Weight Loss
Not sure if you need T2? Take the 60 second quiz:
T2 Videos:
Scientific References
1. Senese R, et al. (2018). 3,5-Diiodothyronine: A Novel Thyroid Hormone Metabolite and Potent Modulator of Energy Metabolism. Frontiers in endocrinology. doi:10.3389/fendo.2018.00427.
2. Senese R, et al. (2019). 3,5 Diiodo-l-Thyronine (T₂) Promotes the Browning of White Adipose Tissue in High-Fat Diet-Induced Overweight Male Rats Housed at Thermoneutrality. Cells. doi:10.3390/cells8030256.
3. Lombardi A, et al. (2009). 3,5-Diiodo-L-thyronine rapidly enhances mitochondrial fatty acid oxidation rate and thermogenesis in rat skeletal muscle: AMP-activated protein kinase involvement. American journal of physiology. Endocrinology and metabolism. doi:10.1152/ajpendo.90642.2008.
Do you have to be on thyroid medication with Hashimotos? My antibodies were 12 & 8 in 2015 but no one diagnosed me. I checked my antibodies in June and they are now 5 & 5. I would rather not go on medication and hear from others that it does not help with fatigue and weight loss. Ugh! I have not been able to lose weight since giving birth to my last child at the age of 36. That was 23 years ago. I have literally tried everything to lose weight. The only thing that moved the needle was 36 hr fasts which I am now learning is not good for those with Hashimotos. Wondered if starting your T2 could help?
Hi Beth Ann,
You do not necessarily have to be on thyroid medication if you have Hashimoto’s, though you may find it helpful if you have thyroid gland destruction/damage. The goal in someone who has Hashimoto’s is to put your disease into remission so you stop the attack on your thyroid gland. If you can do that then you won’t need to take thyroid medication (or at least it greatly diminishes the odds that you will need to take it).
As far as weight loss goes, T2 can be helpful and has helped many people in similar situation as yours. It’s always impossible to predict how it will impact any given individual, though.
Hi dr child’s, take armour works good but weight does come off ,is it ok to take t-2 with it? Thanks jean
Hi Jean,
Absolutely, T2 pairs very well with Armour Thyroid and provides an additional boost to metabolism which can help with stubborn weight. The starting dose would be 100 mcg per day, but you may ultimately need 200 mcg per day.
So do I take this supplement and my 100mg levothyroxine?
Hi AnneMarie,
Yes, that is correct. This would be used with your levothyroxine.
Hello my name Christina Jensen I seriously suffer from hyper thyroid issues please give me someone to help me
Will this be helpful for hyperthyroidism as well? if not what is your recommendation?
Hi Regina,
Yes, but you would only want to use it if you have:
1. Undergone thyroid removal or radioactive iodine ablation.
Or 2. Are currently doing add-back or block and release treatment.
If you are actively hyperthyroid and taking methimazole, you would not want to use it. But most hyperthyroid patients are actually hypothyroid and just don’t realize it since all of the treatments for hyperthyroidism result in permanent thyroid gland reduction and reliance on thyroid medication for life.
I take Armour Thyroid 90 mg. Would this still be helpful?
Hi Connie,
Absolutely. T2 is great for those without a thyroid because they no longer produce any thyroid hormones. It’s even more important in this situation.
I still have my Thyroid.
Hi Connie,
Sorry, I must have confused your comment with another! T2 is great to use alongside Armour Thyroid because Armour contains very low amounts of T2, if any. Adding T2 helps complement the T4 and T3 in Armour by supporting metabolism and cellular thyroid signaling without pushing T3 too high. It is a simple way to round out what Armour provides.
I am taking Armour thyroid 30mg. I only get blood work done every 6 months, but feel lousy every day. So tired I could sleep all day. I am 81 years old and have been on thyroid medicine for years. Do I take the T2 with the Armour? Thanks, Suzanne
Hi Suzanne,
Yes, you can take T2 at the same time as your Armour, and that is how most people do it. I recommend taking them together in the morning as you usually take your Armour, and avoid calcium or iron within 4 hours since those can interfere with thyroid meds.
I had RAI therapy and now I take Armour Thyroid. Could a T2 supplement possibly help me if I have no thyroid? I do feel sluggish and tired quite a bit.
I have been on levothyroxine for many yrs over 40 and I am still tired and constantly cold feeling like I have internal shivers all the time. I have spoken to my new Dr. and we agreed to try Armour. I was thinking of taking T2 also but should I wait and see how the Armour works first. I am going to start it on April 1. How long if I wait before I try the T2.
Hi Deb,
After 40+ years on levothyroxine with persistent cold and fatigue, T2 is exactly what I’d recommend here. Those symptoms point to sluggish mitochondrial function, and T2 directly stimulates mitochondrial activity and thermogenesis in a way that T4 and T3 don’t. It’s the overlooked piece for a lot of thyroid patients who still feel cold and tired despite being on medication.
You can absolutely start T2 right away alongside your transition to Armour. T2 is available over the counter and works through a different mechanism than T3/T4, so there’s no conflict. In fact, combining Armour (which gives you T4 and T3) with T2 covers all three major thyroid hormones and tends to give the best results for patients with your symptom profile.
Give everything about 6-8 weeks, then recheck your labs (TSH, free T3, free T4, reverse T3) to see where you stand.
I take Thyroid medication. Do I just buy the T2 medication. I also would like to lose some weight. What should I be taking?
Hi Dr, I would like to buy T2 but I ran across information stating that it cannot be monitored like T4 and T3, and it can lead to heart problems. Should I be concerned?
Hi Michelle,
Great question! The answer is no, you shouldn’t be concerned.
I broke down the myth that T2 causes heart problems in this article here: https://www.restartmed.com/side-effects-of-t2-thyroid-hormone/
The bottom line is that if you use T2 in doses of less than 300 mcg per day, there is no risk of heart problems or any other issues. Essential T2 provides 100 mcg of T2 per serving, which is very far away from this threshold.
If you have any other questions, please let me know!
under active thyroid because of hysterectomy taking 60 mg of Armour can i take this too?
Hi Sandra,
Absolutely. T2 is great for all cases of hypothyroidism and for those taking NDT formulations like Armour Thyroid. Armour likely contains a small amount of NDT, but not a sufficient amount to cover your physiologic needs, which is why I see patients taking NDT thrive when they add additional T2.
I take 0.137MG once a day of levothyroxine. If I bought this product, how much would I use? I do have so many of these symptoms especially the sluggish feeling every day.
Would this still benefit someone who is on only a small dose of Armour (60 mg) and the remainder is the T3-only Liothyronine (50 mg) or would it be duplicating what is already in the Armour?