How Long Does it Take Thyroid Medication to Work?

How Long Does it Take Thyroid Medication to Work?

Have you recently started taking thyroid medication?

Are you still waiting for it to kick in?

If so, then this is the article for you. 

The short answer to your question is that it takes around 6 weeks for thyroid medication to kick in and for you to start feeling better. 

The long answer is that it can be shorter than that or even longer depending on several factors. 

Learn more about what factors influence how quickly you will feel better, what things can be sabotaging your medication from working, and how long it will take you to lose weight

How Long Does it Take to Feel Better?

As I said before, if you are just starting thyroid medication then you should expect to wait about 6 weeks before you start noticing any difference. 

Why does it take so long for thyroid medication to work?

Unlike other medications, thyroid medication acts as a hormone inside of your cells. 

Thyroid hormone circulates through your body, enters into your cells, latches onto the nucleus, and directly changes your genes through genetic transcription (1). 

As you can imagine, this process is not instant. 

It takes time to take effect.

There is no immediate “on” switch like there is for other functions in your body and using thyroid medication just takes time. 

Does that mean it takes 6 weeks for everyone?

Not at all. 

In fact, some people notice an almost immediate difference when they take thyroid medication (even after the first pill)

Usually, this is an indication that they are severely deficient in thyroid hormone. 

For those people with mild deficiency, however, it can take up to the full 6 weeks or anytime in between. 

Finally, it’s not uncommon for it to take even longer than the cited 6 weeks as well. 

Some people just respond slower than others to typical medications and doses and there isn’t anything you can do about it. 

It’s also important to remember that other factors can influence how quickly you will feel better. 

Things to consider when it comes to waiting for your thyroid medication include:

#1. Your starting dose

Generally, the higher your starting dose the quicker you will start to feel better. 

That doesn’t mean you should jump to a high dose, however, as higher doses may cause symptoms of excess thyroid hormone. 

#2. Are you taking T3?

Another important factor is whether or not you are using T3 thyroid medication. 

People who take T3 thyroid medication will often feel better even sooner than those taking T4 medications like Synthroid or levothyroxine


Because T3 is the most active thyroid hormone and it doesn’t require activation in order for it to work. 

#3. Is your lifestyle healthy?

No amount of thyroid medication is going to make you feel better if your diet is not clean, if you are not sleeping at night if you don’t exercise, and if you are stressed out of your mind. 

If you don’t take care of these things then you may continue to feel poorly while taking thyroid medication even if you are taking ‘enough’. 

There are also plenty of other factors which influence the length of time it takes thyroid medication to kick in and some of these are within your control. 

Whether you realize it or not, you may accidentally be sabotaging yourself by doing certain habits which influence how effective your thyroid medication dose can be. 


Foods to Avoid if you Have Thyroid Problems:

I’ve found that these 10 foods cause the most problems for thyroid patients. Learn which foods you should avoid if you have thyroid disease of any type.


The Complete List of Thyroid Lab tests:

The list includes optimal ranges, normal ranges, and the complete list of tests you need to diagnose and manage thyroid disease correctly!


Reasons You May Not Be Feeling Better

What if you’ve waited for more than 6-8 weeks and you still aren’t feeling any better?

If this is you then don’t panic. 

There are no fewer than 8 reasons you may not be feeling better that could potentially explain your persistent symptoms. 

If you still remain symptomatic after taking your thyroid medication then make sure to read this list below. 

But most of all, remember to be patient!

It can take a while to get your dose dialed in and the entire process can take months. 

Don’t let this discourage you, however, because there is a high chance that you will get to where you need to be. 

Just remember:

It’s not normal to feel poorly if you are still taking thyroid medication. 

#1. You are taking your medication with food. 

One simple thing to remember when you take thyroid medication is to never take it with food!

The only thyroid medication that you can take with food is Tirosint (2) (and even then it’s probably not recommended). 

Typical thyroid medications such as levothyroxine and Synthroid absorption can be blocked if you take them with food. 

This is why your doctor (and pharmacist) should have told you to take your medication on an empty stomach. 

Whether or not you listened to them is a different story!

join 80,000 other thyroid patients who have used dr. westin childs' thyroid support supplements.

Taking your medication with food in your stomach may limit the amount of thyroid hormone your body can absorb (3). 

So, even if you are taking the right medication, at the right time, and in the right dose, it’s still possible that it’s not getting into your body. 

Make sure you take your medication on empty stomach and give yourself enough time before you eat. 

Most people recommend no food 1-4 hours before or after you take your medication. 

You can learn more about other tips and tricks when taking your thyroid medication in this post here

#2. Your dose isn’t high enough. 

Another common reason you may not be feeling better is that your dose is simply not high enough!

This actually happens a fair amount.  


Because your doctor would much rather accidentally underdose you than overdose you. 

Doctors do the same thing with other medications such as insulin for diabetics (4). 

But, even if your doctor wants to get you on the right dose, the chances of him or her putting you on the exact amount that your body needs on the first try is very slim. 

In the vast majority of thyroid patients, it takes at least 2-5 dose adjustments before you find what works well for your body. 

And, because you shouldn’t check your thyroid labs sooner than 6 weeks, it can take several months for you to fine-tune your dose. 

The good news is that you don’t have to get your dose to the perfect range for you to start feeling better, however. 

Along the way, as you adjust your dose, you should notice small but incremental changes to your symptoms (in a positive way). 

Don’t be afraid to ask your doctor to check your thyroid lab tests if you aren’t feeling back to 100%. 

#3. You need a different type of thyroid medication. 

Most patients with hypothyroidism are started on medication such as Levothyroxine or Synthroid. 

But there are actually many more different types of thyroid medications available than just these. 

Some medications get a bad reputation for unfair reasons, but that’s just the way it is. 

The reality is that these medications have their place in the treatment of certain patients and it’s possible that you are one of them. 

You can split thyroid medications into 3 main groups:

If you aren’t feeling well on T4-only thyroid medication (which is what Synthroid and levothyroxine are) then you may want to at least trial the other medications in the list above. 

These medications can sometimes be trickier to dose, but it’s absolutely worth it if it means that you feel better. 

#4. You are taking your medication with coffee. 

You may be taking your medication without food but are you taking it with your morning coffee?

Coffee is another factor that may be influencing your thyroid hormone absorption and one that you aren’t even considering!

Coffee has the effect of increasing the kinetic movement of your bowels. 

Basically, coffee speeds up the movement of your bowels because of the caffeine content in it which is one of the reasons it can cause you to have a bowel movement. 

This may be a desirable effect for you, but it doesn’t do any good for thyroid hormone absorption. 

The faster your bowels move the shorter amount of time your medication has to be absorbed in the intestinal tract. 

If you are taking your medication with coffee in the morning, you may want to think twice!

If you absolutely have to have your morning coffee then you may find more success switching to Tirosint which is still absorbed even while eating or drinking coffee (5). 

#5. You aren’t waiting long enough. 

This may not be what you want to hear but it may be the truth. 

Sometimes it’s just a matter of time before your thyroid medication kicks in. 

The average length of time it takes for most people to notice a difference is around 6 weeks. 

But that is just the average. 

Some people notice a difference almost immediately (after the first pill) while it may take others longer than the 6-week period of noticeable improvement. 

How quickly (or slowly) it takes to work in your body will depend on how deficient you are, what other problems you are dealing with, and how much thyroid medication you are absorbing. 

If you haven’t noticed a significant improvement after 6-8 weeks then don’t be afraid to go back to your doctor to get your labs re-tested and medication adjusted if necessary. 

#6. Your thyroid isn’t your main problem. 

Another potential explanation has to do with factors unrelated to your thyroid. 

It’s actually possible (and common) for hypothyroid patients to also suffer from OTHER medical conditions. 

And these problems can cause symptoms that mimic hypothyroidism. 


Some of the most common symptoms of hypothyroidism include hair loss, fatigue, and weight gain. 

There are so many other conditions that can cause these exact same symptoms. 

Conditions such as nutrient deficiencies, insulin resistance, leptin resistance, adrenal fatigue, and so on. 

If you’re taking thyroid medication and your lab tests look good but you still remain symptomatic, then you may need to take a look at these other factors. 

#7. You aren’t being consistent. 

If you want your thyroid medication to work then you need to be consistent while taking it. 

What do I mean?

I mean taking it at the same time each and every day. 

By maintaining consistency in how you take your medication you will help even out absorption and bloodstream levels of the hormone. 

If you are taking your medication at 6:00 am one morning and then 8:00 am the next morning or skipping a day here or there then that may explain your persistent symptoms. 

Pick a time to take your medication and stick to it. 

#8. Other medications are interfering with your medication. 

Lastly, another factor worth considering has to do with other medications that you might be taking. 

It’s not uncommon for other medications to interfere with thyroid medication. 

Not all medications do this, but there are certain medications that tend to cause problems. 

Medications that interfere with thyroid hormone include:

If you are on any of these medications you may want to touch base with your Doctor to see if you can find another option. 

Whatever you do, don’t stop taking your medication cold turkey without discussing it with your doctor!

In many cases, you may be able to switch to a different type or class of medication which can often help. 

How Long After Starting Medication Will it Take to Lose Weight?

When should you expect to magically lose all of the weight you’ve gained from hypothyroidism?

Unfortunately, the answer is that most people do NOT lose weight after starting thyroid medication (especially T4-only thyroid medications). 

If you are one of the lucky few people who will lose weight after starting your medication then it will most likely occur slowly and over a period of 3 to 6 months. 

You will probably notice a small amount of weight loss on the scale but over time you should notice that your clothes fit better. 

It’s important to note that this is not common. 

Don’t let this get you down, however, because there are still definitely ways for you to lose weight if you have thyroid disease

Why don’t most people lose weight?

It has to do with what medication you are using, your dose, your free thyroid hormone levels, and other hormones in your body. 

Simply taking thyroid medication isn’t enough to solve all of these problems but it is a good step in the right direction. 

When it comes to weight loss, most hypothyroid patients find success using medications that contain T3 (medications such as Armour thyroid and Cytomel). 

This has to do with the fact that your free T3 levels (and total T3) tend to correlate with weight loss (10). 

The higher your T3 levels the more weight you will lose. 

Standard thyroid medications like levothyroxine do not contain T3 thyroid hormone and so people on these medications may still experience low T3 even though they are taking it. 


If you are taking thyroid medication then you should allow a good 6 weeks from your start date before you start getting worried about whether it is working for you or not. 

Thyroid medication tends to take time to work as it alters genetic transcription inside of your cells. 

This waiting game can be frustrating, but it’s just how it goes. 

There are also many other reasons which can limit how effective your thyroid medication can be. 

If you have been taking your thyroid medication faithfully for 6 weeks or longer then you may want to look at these other factors. 

Now I want to hear from you:

Are you taking thyroid medication right now?

Are you feeling better?

How long did it take for you to notice a difference? Are you still waiting?

Leave your questions or comments below! 











is your thyroid medication working?

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About Dr. Westin Childs

Hey! I'm Westin Childs D.O. (former Osteopathic Physician). I don't practice medicine anymore and instead specialize in helping people like YOU who have thyroid problems, hormone imbalances, and weight loss resistance. I love to write and share what I've learned over the years. I also happen to formulate the best supplements on the market (well, at least in my opinion!) and I'm proud to say that over 80,000+ people have used them over the last 6 years. You can read more about my own personal health journey and why I am so passionate about what I do.

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41 thoughts on “How Long Does it Take Thyroid Medication to Work?”

  1. Hi there, just curious about your thoughts on thyroid and bio-identical homones like progesterone? That research article in your link is about estrogen (E2) and the thyroid.

    • Hi Lisa,

      Generally, progesterone is safe to use with thyroid medicatin provided you are deficient (but many situations can alter this general statement).

      • My main complaint is the shaking and jitters and instead of getting to the bottom of the T3,T4 they just keep giving me anxiety meds which I hate.

  2. Hi Dr. Child’s- I love reading your articles and watching your You Tube. I just received all of my shipments of your supplements and anxious to see how they work…. I readyout article about the different T3 medications and I see that you prefer IR vs SR T3. I was on SR for a long time and just switched to IR.., you didn’t really go into why you prefer IR ? Another doctor I follow prefers this as well, but she didn’t go into it either. Any info would be appreciated!

    • Hi Meghan,

      I’ll have to do an article about that in the future but the very short version is that it simply works much better for most patients most likely due to intestinal issues that many thyroid patients suffer from.

    • Hi Dr. Child’s,

      After successfully being on Naturethroid for 6 years, being switched to WP during the backorder and then back to reformulated Naturethroid and not doing well (fatigue, hair loss, joint pain and brain fog) I was switched to NP which seemed to be an improvement the first month and the next refill smelled awful and I went downhill again. I was switched to compounded synthetic t3/t4 which seemed to improve everything but left me with a headache at the top of my head. Now I am on armour and seems to be getting better but have developed reflux and hair is starting to fall again . I have been on armour about 9 weeks slowly going up. My question is how do you know if the medicine is not agreeing with you or you need more time. My labs have stabilized but my ‘tsh’ is higher now at 2.6. I was able to be optimal on Naturethroid 1 grain for years but can’t seem to figure this out. I’m am on 45 mg of armour.

  3. Hello there.
    I was diagnosed with Hypothyroidism and was put on Synthroid and after testing normal my does was ( 137 mcg ) ..
    My issue is I feel worse then I did before I started taking this…
    So is this normal will it level out?

    • Hi Sherell,

      That definitely occurs but I wouldn’t say it is normal. And no, there are some people who just start levothyroxine and never actually feel better and there are some where it takes a while to “kick in”.

  4. I have bad low back and hip muscular pain last 6 months. I’m on T4. Just added T3 and LDN. Is there a good chance this will resolve my pain. I’m supposed to be going overseas in 3 months. I don’t think I can go if I’m like this

    • Hi Julie,

      It really depends on the main cause of your muscle pain. For instance, your muscle pain could be caused by something unrelated to your thyroid in which case thyroid meds would have no impact. If it is the thyroid, and if you are on the right dose, then it should resolve within a few weeks.

  5. Hello Doctor,
    I am 53 and have been on either Synthroid or Levothyroxine since I was 25. I never really experienced any symptoms as my doctor picked it up on a routine screening and started me on meds after that. I believe my tsh was up in the 20 something range and after that had been normal ever since. 3 years ago I had a hyst/bso and was started on estradiol, and have required dose adjustments in my thyroid twice due to my tsh being above range. Is this common after a hyst and being on estrogen? Also, I have never taken it on an empty stomach but I am going to start! I start feeling foggy when my dose is even a little out of range. I recently had a physical and all my other routine blood work is normal.

  6. I’m 39 and have been on generic Levo since I was about 30, after a partial thyroidectomy due to a hurthle cell adenoma at the age of 27. I don’t recall any bad effects on synthetics T4 only therapys once I got up to .88mcg, however over the past 3-4 years I’ve had periods of time when I have more fatigue, crashes, and aches and pains.

    A few months ago symptoms got pretty bad so I called my pharmacy to inquire if they had changed the pharmaceutical company that provides their generic levo and sure enough they had. Decided I would try Synthroid for the second time, once at .75mcg and the second at .88mcg, which has been my usual dose for 10 years, but each time I suffered from terrible muscle weakness and fatigue, could barely lift my arms and couldn’t get out of bed.

    This week I went to a Dr that focuses on the whole patient and not the numbers. I’m currently trying 1g of NP Thyroid. Today, is day three and I feel some weakness and fuzziness but trying to keep hopeful that this will get me back on track and I’ll be able to get my energy and strength back. I’ve found that it’s harder to switch brands and get it right than it is initially starting, as you said your body is usually so deficient in thyroid hormone already that you start feeling better from the get go.

    When switching brands or types of thyroid therapies any idea if it takes a little longer to acclimate? On the NP chart there wasn’t a conversion for .88mcg to NP thyroid, only 100mcg which is 1g of NP. I’m starting off at 1g of NP, which is 60mg equivalent to 100mcg and it almost feels like I need a little more after 3 days. Is natural combo thyroid medication less potent than synthetic? Should I give it a week to see if I normalize and level out before moving up? Does it take that long?

  7. It has taken me a year to feel slightly better on levothyroxine. I still don’t feel great. Tried taking medication at the same time each day for months. I take it now when I get up and have breakfast at least half an hour later.

  8. Hi,

    I have Hashimoto’s disease and was diagnosed in 2007. Initially, when I went on levothyroxine, I did lose a good deal of the weight I’d gained and my hair filled back in almost completely.

    I ended up moving my entire family back in with my parents so I could care for my mom through breast cancer- she fought for five years before the disease took her last year. In that time I completely neglected my own health and only recently finally met with my GP. My levels were beyond low. She started me at 100mcg levothyroxine and I did notice less overall exhaustion within just a few days. My hair thinned severely during this last thyroid drought so I began using minoxidil 5% mousse. Is it okay to continue that and my thyroid medication or will I potentially end up looking like chewbacca? Also, can armour and levothyroxine be taken together?

  9. Does the ARMOUR THYROID have any side effects ? I am currently on 50 Levothyroxine. It’s hard to lose the weight and so I wanted to know the comparison in side effects compared to both ?

  10. Hi Doctor,

    I’ve been on Levothyroxine 50MCG for my thyroid for about 2 weeks now. I have not seen a lasting change yet except that I find about an hour or so after taking the medication, the throbbing, stabbing foot pain I’m currently getting in my left foot towards the arch area seems to disappear or temporarily subside! Is there a correlation between the throbbing foot pain and the thyroid being out of whack?

  11. Greeting from Bosnia, thank you for all of your work, I learned a lot watching your YouTube videos regarding thyroid gland, supplements, etc. I am on my 25th day of taking 100mcg of Levothyroxine, I don’t feel any change in my emotions, energy, mood, nothing at all, I am starting to worry more and more, I am afraid that this medication is not helping me with Hypothyroidsm caused by Hashimoto’s.

  12. Loved your article. I was feeling better in 3 days after starting levothyroxine. Then a few days later I felt so tired that I couldn’t function. I could not think of a reason for this unless a virus or my thyroid, then the next day, after sleeping 12 hours I felt like a new person and have since then. It’s been 6 days since this happened. This is my reason to read more about Hypothyroidism. Prior to being diagnosed, I was exhausted, my hands swelled so none of my rings fit, pain in my legs for no reason, I didn’t feel like doing anything, I needed to sleep a great deal more than my normal 8-9 hours. I’m 58 years old and well past menopause. So gaining 5 pounds a year I figured was normal even though I don’t eat a great deal. I have noticed I feel very bloated if I eat bread/grains so I have cut them out and other than the 1 day, I feel wonderful, like a new person. I’m ready to go do things again. Life is wonderful. I have a slow colon so based on what I was reading, that may be why the medicine worked so much faster for me?!?!? Thank you for your article.

    • Hi Bargietornados,

      You are probably someone who just converts T4 into T3 very rapidly which is a great thing if you have thyroid problems.

  13. Good Morning!! I was on Synthroid 0.125mcg. And My Doctor just was changed my Meds to Unithroid 0.125mcg due to several symptoms I was having. She said that Unithroid has less ingredients because I have alot of allergy problems. I have only been on for not even two weeks yet and I feel very nervous. I do have anxiety already …but this just seems more inclined than I was and in my stomach alot . Is that normal?
    Should I give it more time or let my Doctor know ?. Thank You

    • Hi Susan,

      Unithroid isn’t much different from Synthroid. If it’s not working for you then you would know pretty quickly.

  14. Hello Dr. Childs

    I love your articles, very specific, and easy to understand.
    I’ve been, on 75mcg. Synthroid, and 5mcg Cytomel. For 15 years. Some how, I forgot to take my cytomel, (I don’t know, for how long) until I start, feeling, awful, luck on energy, sluggish, gaining weight, (dieting, and eating, very light, and exercising, as usual). Went back to my Dr. who put me back on 5 mcg cytomel. Although symptoms persist, and I keep going up on weight, (more than 20 Lbs, on 10-11 months).
    I just switch Dr’s. Who has switch 75mcg of Synthroid, for 75 mcg, Unithroid. (5mcg of Cytomel, kept the same) I’ve been taking Unithroid for 10 days, I’m still have puffy face, swollen, all over, hands, feet) And a huge inflamed like, stomach. I don’t think, just switching from Synthroid to Unithroid, will be the solution.
    What would you, think, and suggest ?

    Thank you

  15. Good Morning:
    I saw my doctor recently and he changed my thyroid medication from 75 to 112. I happen to have medication from 88 and 100 in my medicine cabinet from a switch within this year. Should I take the 88 and then the 100 before I start to take the 112? I thought I read that a gradual increase was best. If so, how long should I take the 88 and 100 before I go to the 112?

  16. I’ve been taking cytomel for two weeks with no symptoms whatsoever. You said it takes six weeks, but I am taking pure t3 at very high doses, 100 than 150, so it should kick in a lot sooner I would think. Is it possible they’re fake? I cannot get a thryoid test right now.

    • Hi Jane,

      I suppose it’s possible that it’s fake if you bought it overseas or something like that. Taking a high dose of 100 to 150mcg without physician supervision is also risky so I’m not sure I would condone such action if that is the case.

  17. Dr. Childs,
    I went for routine blood work, and my doctor said my thyroid level is in the low-normal range. I have no symptoms, and feel fine (for a 58 year old woman). She prescribed a low dose, 15 mg, of Armour Thyroid, to take once a day in the morning. She did not go over the potential side effects with me. The first day, I felt a little anxiety. I am very sensitive to medication and any stimulant (I never use anything with caffeine in it). I also felt some abdominal discomfort. The same happened on the next day. The third day I also had some shortness of breath. It is a holiday weekend, and nobody was available to talk to about it, so I decided it is best to not take this medication, since I really don’t need it, and I now have read all the side effects. My question is if it was safe to go off of it suddenly, since I only took it for three days?

    • Hi Cindy,

      Unfortunately, I can’t give you advice regarding what you should do with your thyroid medication. I would recommend that you call your doctor to see what their thoughts are before proceeding.

      It most likely won’t cause any issues to go off of it but I’m not your doctor and I don’t have all of the information necessary to make that call.

    • Hi Ralph,

      It could be due to many reasons. The only way to find out is with a complete and comprehensive history and physical.

  18. I have been on levothyroxine for 20 years. Suddenly this year, my thyroid started going wonky. My doctor adjusted my meds so many times this year. I was on .137 then .15, then .2, then .175, then .15 again. All within the year.
    I think the pharmacy might even have screwed up somewhere in there. I just started the lower dose this week. I just feel so jittery. Even though the last 3 doses have been decreasing, will it still take 6 weeks to feel better?

    • Hi Cheryl,

      Yes, 6 weeks is about the average time it takes to see a difference in thyroid function after altering your dose.

  19. I started Armour 10 days ago. I had been on Levothyroine for 20 years. I was not converting T4 to T3, so this change was made. I take 2 30mg tabs in the morning and 1 in the evening. I feel terrible. I have an on going thumping in my neck, I am depressed and have a whole lot of anxiety. My doctor is having me take Gaba to slow these feelings down.
    I’m scared. Not sure if my doctor is doing the right thing. I am very sensitive to medications.

  20. Greetings!
    I had no idea I had hypothyroidism, not a clue, just thought I was a delicate sensitive person, then perrimenopause, then maybe it’s HRT side effects. I also struggled to loose weight so was agressive with diets, clean eating, no alcohol, no caffeine, no white carbs. But, it was still hard to function. As a typical woman I just pushed on and sucked it up.

    After a full blood test done on Monday (my GP wanted to check everything just incase anything was lurking, because I’m a Therapist), surprise surprise……I have a very underactive thyroid. Didn’t even know what that was. Picked up this stuff called levothyroxine and took my first 50 tablet three days ago, not expecting much at all.

    From the first dose, I felt a flutter in my throat about an hour after taking it. Later that day I noticed I was walking faster. Sitting straighter, and doing things I hadn’t been interested doing in years.

    I’ve since read up about this mystery and I’m flabbergasted! My symptoms go back 19 years!!!! I thought everyone felt like me, just getting older etc. I am amazed. Spent most of the day singing and dancing in the kitchen in between client zoom sessions and cant wait to live the rest of my life. I am delighted beyond reason.

    I think it worked fast because my system is very clean, and I was very deficient. Just wanted to share my experience with others. I understand that the journey won’t be all smooth sailing, but compared to how I had resigned myself to living for almost two decades, I’ll roll with the punches……with relish!

  21. Is it common for a Dr. To prescribe a dosage of 100mcg of Synthroid for 6 days and then I take 150mcg on the seventh day. Just wondering, have been doing this for 3 weeks and still feel bad. How long does it take for me to see a difference.

    • Hi Angela,

      I wouldn’t say it’s common but it does happen for sure. It generally takes at least 4-6 weeks to see improvement in your symptoms when taking thyroid medication provided you are taking the right dose and type of medication.


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