Essential T2Bioidentical T2 Thyroid Support Supplement (3,5 Diiodo-L-Thyronine)
$41.99 — or subscribe to save 10%
- Metabolism & energy support: 100% bio-identical T2 in its most active form (3,5 diiodo-l-thyronine), bypasses the need for thyroid conversion & directly activates your cells*
- Targets stubborn fat: activates brown adipose tissue (BAT) to help turn stored fat into heat & energy*
- Batch-up manufacturing: unlike other T2 supplements, our methodical manufacturing process ensures consistent and reliable dosing in every capsule*
- Doctor-dosed for safety: designed to be usable with all thyroid medications, without the risk of overstimulation or “jitters”*
No proprietary blends, fillers, or glandular.
What’s inside
- 100% bio-identical T2 as 3,5 diiodo-l-thyronine, 100 mcg per capsule
- Batch-up manufacturing for consistent and reliable dosing in every capsule
- Only 3 other ingredients: hypromellose capsule, microcrystalline cellulose, and non-GMO vegetable magnesium stearate
No proprietary blends, fillers, or glandulars. See the doses and research below.
How to use
Start with 1 capsule per day (100 mcg) and increase to 2 capsules after a few days as tolerated. Take it in the morning, on an empty stomach, at least 30 to 60 minutes away from other supplements. It can be taken at the same time as every type of thyroid medication.
Shipping and returns
Free US shipping on every order, processed within 1 business day, arriving in 3 to 5 business days via USPS Ground Advantage. 60 day money-back guarantee: if it does not work for you, return it for a full refund. No questions asked.
Formulated by thyroid expert Dr. Westin Childs
T2: the “missing” hormone your doctor never mentioned
Most patients focus on T4 and T3, but they’ve been left in the dark about T2. While T4 and T3 handle the big systems, T2 specializes in your metabolism and mitochondria, acting as your internal thermostat.[1][3]
If your metabolism feels sluggish but your labs look “great”, T2 may be the missing link.
Join thousands of patients using T2 daily for a better metabolism, all-day energy, and comprehensive thyroid support.*
Dr. Westin ChildsThyroid specialist and formulator
T4 and T3 handle the big systems
Levothyroxine and Synthroid give you T4. Cytomel and liothyronine give you T3. The healthy thyroid gland produces four thyroid hormones though: T4, T3, T2, and T1. By taking T2, you’re more closely mimicking the healthy thyroid gland.*
T2 specializes in your metabolism
T2 works on your metabolism and your mitochondria, acting as your internal thermostat.[1][3] If your metabolism feels sluggish but your labs look great, T2 may be the missing link.*
It’s the one you don’t need a prescription for
The only prescription thyroid medications that contain T2 are the NDT family, like Armour Thyroid and NP Thyroid. Essential T2 is the only thyroid hormone you can buy over the counter.
Do you need more T2?
Signs you need T2
When you take thyroid medications (of any type) including levothyroxine, you are shutting down the natural production of thyroid hormones from your thyroid gland. This is both a good and a bad thing. Good because it is providing you with the hormone that you desperately need but bad because it’s also shutting down the production of other thyroid hormones such as T3 and T2 in the process.
You’re still symptomatic on thyroid medication
If you are still experiencing low thyroid symptoms even while taking thyroid medication (and other factors have been ruled out), then it’s likely your thyroid hormones are not optimized.
Your labs look “great” but you feel sluggish
If your metabolism feels sluggish but your labs look “great”, T2 may be the missing link.
Your resting heart rate or body temperature runs low
Proxy measurements of your metabolism such as your resting heart rate and basal body temperature can track with your thyroid status.
Your T3 is low
The major source of T2 in the body is from T3 to T2 conversion.[4] If your body is low in T3 then you know you lack the substrate to make T2.
What is inside
Ensuring accuracy and results in every dose
The actual supplement facts panel. Click to enlarge.3,5-Diiodo-L-Thyronine 100 mcg
The only active ingredient in the bottle. By supporting T4 and T3 function, and through its own cellular action, T2 thyroid hormone:
- Regulates basal metabolic rate[1][6]*
- Activates detoxification enzymes in the liver*
- Activates brown adipose tissue[2][10]*
- Increases cellular ATP production[3]*
- Regulates cholesterol production[8]*
- Assists muscles in burning fat and maintaining muscle health[10]*
- Protects kidney function*
- Assists in the regulation of blood sugar*
- Helps determine muscle tone*
Bioidentical T2 as 3,5 diiodo-l-thyronine
Essential T2 provides an exact match replica of the T2 thyroid hormone that your body would produce naturally, in its most active form. This ensures maximum usability in your cells, better synergy with other thyroid hormones, and better symptom control.[5][7]*
Batch-up manufacturing accuracy in every capsule
As a pioneer in T2 supplements, Dr. Childs has created a batch-up manufacturing process. This process of blending and mixing our raw material allows for the even distribution of thyroid hormone throughout the entire manufacturing process, from mixing to encapsulation.
Nothing else in the capsule 3 other ingredients
Hypromellose capsule, microcrystalline cellulose, and non-GMO vegetable magnesium stearate. No blend, no fillers doing nothing, and no glandular.
Real-world patient outcomes
What thyroid patients actually report
“My resting heart rate increased from 45 to 65 bpm, my temperature came up above 98 degrees for the first time, and I started sleeping 7 to 8 hours instead of 4 to 5.”
Night and day difference
Night and day difference in energy and mental clarity within a few days of taking T2. It gave me hope that I could be energized and high functioning again.
It kick started my metabolism
After a long time working to find the right combination of T-4 and T-3, the addition of Essential T-2 kick started my metabolism in a very positive way.
Way more energy than I used to have
This has helped so much with afternoon fatigue! I have way more energy than I used to have for sure!
I have lost 20 pounds
I started taking T2 about 4 months ago and I have lost 20 pounds and I have more energy.
Losing a pound a week
Before I was done with my first bottle, I started losing a pound a week without changing anything else, after stalled weight loss for months.
Not so cold all the time
By the time I finished the first bottle I was aware that my body was not so cold all the time, even in the air conditioning. For me that is a really big deal.
Frequently bought together
Patients often pair it with these
T3 Conversion Booster
Uses zinc and selenium to activate the enzymes that convert inactive T4 into active, fat-burning T3.*
Thyro Mag+
Three advanced forms of magnesium for superior absorption in the three areas you need it most: your thyroid, gut, and brain.
How to use
Simple to add to your daily routine
- 1
Start with 1 capsule per dayIt’s best to start out with 1 capsule per day, which provides 100 mcg of T2.
- 2
Increase to 2 capsules after a few daysIncrease up to 2 capsules per day after a few days, as long as you can tolerate the 1 capsule dose.
- 3
Take it in the morning, on an empty stomachBefore noon, at least 30 to 60 minutes away from other supplements. Can be taken at the same time as every type of thyroid medication, including natural, synthetic, and NDT formulations.
What to expect
Subtle changes start
You may notice initial changes in daily energy and body temperature.
Stronger symptom support
This is where you may notice that your body is starting to respond. You may be more productive and notice your body changing.
Benefits build and compound
This is when T2 may have a more noticeable effect on your body, how clothes fit you, body temperature, and metabolism.
How it compares
See how Essential T2 compares
In an online survey of 12,146 hypothyroid patients, those taking levothyroxine alone reported the lowest treatment satisfaction of any group, a median of 5 out of 10.[11]
| Essential T2 | Other thyroid supplements | Thyroid medication (Rx) | Regular supplements | |
|---|---|---|---|---|
| Bio-identical T2 | ✓ | ✕ | ✕ | ✕ |
| Biologically active T2 | ✓ | ✕ | ✓ | ✕ |
| Precision dosed | ✓ | ? | ✓ | ✕ |
| Made for thyroid patients | ✓ | ✓ | ✓ | ✕ |
| Thyroid safe | ✓ | ? | ✓ | ✕ |
| Created by thyroid expert | ✓ | ? | ✕ | ✕ |
| Usable with thyroid meds | ✓ | ? | ✓ | ? |
| Available without Rx | ✓ | ✓ | ✕ | ✓ |
| High customer approval | ✓ | ? | ? | ✕ |
| Boosts metabolism & energy | ✓ | ? | ? | ✕ |
| 60 day guarantee | ✓ | ✕ | ✕ | ✕ |
Frequently Asked Questions
What is 3,5 Diiodo-L-Thyronine?
3,5 Diiodo-L-Thyronine is the official medical name for T2 thyroid hormone. Each thyroid hormone has a name based on the number of iodine atoms found bound to it.
T4 thyroid hormone is known as thyroxine, T3 thyroid hormone is known as triiodothyronine, and T2 thyroid hormone is known as 3,5 diiodo-l-thyronine.
Don’t let the name confuse you, though, it’s just another way to say T2 thyroid hormone.
How do I know if I need it?
If you are a thyroid patient then there’s a good chance you can benefit from taking T2 thyroid hormone. Here’s why:
Your body creates T2 thyroid hormone in the natural and healthy state. When you take thyroid medications (of any type) including levothyroxine, you are shutting down the natural production of thyroid hormones from your thyroid gland.
This is both a good and a bad thing. Good because it is providing you with the hormone that you desperately need but bad because it’s also shutting down the production of other thyroid hormones such as T3 and T2 in the process.
We don’t know as much about T2 thyroid hormone as we do about T4 and T3 but what we do know suggests that T2 thyroid hormone is an important part of thyroid hormone regulation and plays an important role in several different areas.[5]
In cases of complete thyroid gland destruction (such as radioactive iodine ablation), complete thyroid removal (such as thyroidectomy), and end-stage Hashimtoo’s then using T2 thyroid hormone is a no-brainer because your body is no longer producing it.
Taking T2 thyroid hormone in conjunction with T4 and T3 thyroid medications provides you with a more comprehensive thyroid profile similar to what the healthy thyroid gland produces naturally.
What is the source of T2 used in this supplement?
Essential T2 features a synthetic source of T2.
Thyroid patients sometimes assume synthetic thyroid hormones are automatically bad just because they are synthetic but that isn’t the case.
All thyroid medications are bioidentical, where they differ is the source.
Natural Desiccated Thyroid medications are considered “natural” because they come from animals (usually pigs).
But just because something comes from animals doesn’t mean it’s automatically safe, either!
We know from studies that horse hormones, for instance, can cause problems in humans.
We also know that animal proteins (such as those found in NDT) can exacerbate and flare up the immune system in humans.
What’s more important than the source is whether or not the hormone is bioidentical and Essential T2 contains bioidentical T2 thyroid hormone.
Can Essential T2 be used with other thyroid medications?
Yes! Essential T2 can be used with other thyroid medications.
And, just like other thyroid medications, you will want to treat T2 thyroid hormone in a similar way.
That means taking Essential T2 on an empty stomach, away from food and drink, and at least 30-60 minutes away from other supplements and medications.
It is also likely that T2 thyroid hormone will help both T4 and T3 thyroid medications work more effectively.
How can I test my T2 level?
Unfortunately, right now there isn’t a readily available way to test your free T2 level.
The testing for T2 exists but right now it’s primarily used for research purposes.
Even though you can’t directly test your T2 level, there are still ways to indirectly assess whether you have enough.
Here are a few:
#1. You can estimate your T2 level by looking at your T3 level. This works because the major source of T2 in the body is from T3 to T2 conversion.[4] If your body is low in T3 then you know you lack the substrate to make T2.
#2. You can look at proxy measurements of your metabolism such as your resting heart rate and basal body temperature. These are not perfect measures of your metabolism, but they can track with your thyroid status (but not always).
#3. You can look at your thyroid symptoms. If you are still experiencing low thyroid symptoms even while taking thyroid medication (and other factors have been ruled out), then it’s likely your thyroid hormones are not optimized. In a perfect world, you should optimize T2 levels like you would optimize T4 and T3 levels.
How do you take it?
For best results, take 1-2 capsules in the morning, on an empty stomach, and at least 30-60 minutes away from other supplements. Can be taken at the same time as thyroid medication.
Because Essential T2 contains thyroid hormone, you will want to take it in a similar way as your thyroid medication (if you take any).
It’s best to start out with 1 capsule per day (which provides 100mcg of T2) and increase up to 2 capsules per day after a few days as long as you can tolerate the 1 capsule dose.
How long can it be used?
Essential T2 can be used indefinitely (forever if you want)!
Why? Because it’s bioidentical to the thyroid hormone that your body produces naturally.
In a healthy state, your thyroid produces T2 continuously throughout your life.
This is not the case in many hypothyroid patients, though, so Essential T2 serves to replace that lost thyroid hormone via supplement form.
Will it interfere with my thyroid lab tests?
When used at the correct dose, Essential T2 should not have an impact on thyroid lab tests.
This is based on studies that show that using doses of up to 300mcg per day does not significantly impact TSH, free T3, and free T4 levels.[6]
Whenever you are trying to improve your thyroid function, though, whether that be through natural therapies or with the use of thyroid medications, it’s always a good idea to keep an eye on your thyroid lab tests.
If you notice a change in how you are feeling, then rechecking your thyroid lab tests (with a complete thyroid lab panel) would be a good idea after 6-8 weeks of continuous use.
With physician supervision, if you see changes in your thyroid function, then you can make appropriate changes to your thyroid medication at that time.
What are the side effects?
Essential T2 is generally very well tolerated when used at our recommended doses.
Patients have reported side effects that range from more energy, a better quality of life, higher metabolism, weight loss, improved sleep, reduced brain fog, and many others.
Because your thyroid influences just about every cell in your body, the side effects that you may experience when improving thyroid function are variable.
In other words, the benefits you obtain from using it might be different from the next person and so on.
How is Essential T2 different from thyroid medications?
Thyroid medications like levothyroxine and Synthroid contain T4 thyroid hormone in the form of thyroxine.
Thyroid medications like Cytomel and liothyronine contain T3 thyroid hormone in the form of triiodothyronine.
The only prescription thyroid medication that contains small amounts of T2 are medications in the Natural Desiccated Thyroid family, which include medications like Armour thyroid, NP thyroid, and Nature-Throid.
T2 thyroid hormone is the only thyroid hormone that doesn’t require a prescription medication because it is not as powerful as the other hormones mentioned.
Can you test T2 levels?
There are no standard tests available for testing free T2 levels, unfortunately. Assays are currently being developed, though,[7] and T2 testing will likely become a regular part of thyroid hormone testing in the future.
There will likely come a time when thyroid patients receive all thyroid hormones as part of their thyroid medication regimen, including T4, T3, and T2.
Can I use Essential T2 if I don’t have a thyroid gland?
Yes, not only can you use it in this situation, but it would also be a great idea to do so!
The reason is simple:
Once your thyroid gland has been removed, it can no longer produce any thyroid hormone, including T2.
This means your only method of obtaining T2 thyroid hormone is via supplement form or through medications like Armour thyroid.
Many thyroid patients without a thyroid are not taking these medications, though, which means they are not benefitting from T2 thyroid hormone.
This same concept applies to those who are post radioactive iodine ablation and those in end-stage Hashimoto’s.
How long will it take to see results?
Thyroid function is slow to respond when compared to other hormone systems in the body.
It takes 6 weeks of daily use of any thyroid hormone or thyroid support supplement before your body will reach a steady state, which means it will take this long before it completely enters your system.
It’s usually around this time that you will start to see changes in how you are feeling, but I recommend using any thyroid support supplement or medication for at least 90 days before determining whether or not it’s working for you.
How can I tell if it’s working?
The most obvious way will be to assess your symptoms or how you are feeling!
T2 thyroid hormone shouldn’t have a big impact on your thyroid lab tests (which is by design), so the best way to assess if it’s working is based on your symptoms.
Most people have an intuitive sense of how they are feeling and can tell if thyroid support supplements are working based on that alone.
If you are having a harder time keeping track then I recommend keeping a journal or record of things such as your daily energy level, how you are sleeping, the quality of your sleep, your body temperature, your resting heart rate, your body fat percentage, your body weight, and a general sense of your mood.
These are all indirect measures of thyroid function and can help you determine how Essential T2 is helping you.
Can it be used with Dr. Westin Childs’s other supplements?
Yes! I created Essential T2 with both thyroid medications and thyroid supplements in mind.
It wouldn’t be a very good thyroid support supplement if thyroid patients couldn’t use it with other thyroid medications or thyroid supplements!
It can safely be used with all of my other thyroid support supplements and will become a part of certain thyroid bundles in the future because I believe it is that important for healthy thyroid function.
Can I use it if I’m already taking NDT medications like Armour thyroid or NP thyroid?
Good question, and yes! Formulations of natural desiccated thyroid such as Armour thyroid contain some amount of T2 thyroid hormone, which is why this question comes up.
The dosing of T2 in NDT is variable and is not felt to contribute significantly to the effectiveness of these medications.
What other inactive ingredients are included in Essential T2?
Aside from the active ingredient (3,5 Diiodo-L-Thyronine), Essential T2 contains hypromellose, microcrystalline cellulose, and Nu-Flow Rice Fiber.
All of these inactive ingredients are considered very safe and should not cause any issues.
They are included in this supplement to ensure consistent dosing of the active ingredient so that you know you are getting as close to 100mcg per capsule as possible.
Will Essential T2 help me lose weight?
Essential T2 is not considered a weight loss supplement. It is considered a thyroid support supplement that was designed to provide thyroid patients with a more balanced thyroid hormone profile.
Having said that, studies that evaluate the effect of T2 thyroid hormone on the metabolism have been positive.
It’s clear that T2 thyroid hormone does have some impact on both metabolism and the T3 receptor.
One animal study showed that using 300mcg/day of T2 caused a significant increase in resting metabolic rate (metabolism) with a corresponding decrease in body weight over several weeks.[6]
These benefits were seen without altering free T3, free T4, and TSH levels.[6]
When used correctly and in conjunction with healthy lifestyle changes, it’s possible that weight loss may be a positive secondary side effect of its use.
I don’t recommend using T2 for the primary purpose of weight loss, though.
It’s best used to provide your body with normal thyroid hormone regulation, and if the result of that is weight loss, then that’s great.
But, the potential for abuse is too high, which is why it should only be used by those who need it (those with thyroid dysfunction).
If you are a thyroid patient who is struggling to lose weight, optimizing your thyroid function is a necessary step as it controls and regulates your metabolism.
When using any thyroid support supplement, including Essential T2, combine it with a healthy whole-food diet, regular exercise, and intermittent fasting for the best possible results.
How does shipping work?
All domestic orders receive free shipping regardless of price. Orders are typically processed within 1 business day, are shipped out via USPS Ground Advantage, and typically arrive within 1-3 business days.
We also offer international shipping to most countries! International orders ship free if the order value is greater than $250 USD. Otherwise, the price of shipping is calculated on the checkout page. We primarily use USPS for international shipments.
What is your Return/Refund Policy?
All of my products come with a 60-day money-back guarantee. I’m confident that my products will work for you, but in case they don’t, for whatever reason, you can return them for a full refund within 60 days. It makes purchasing them a no-brainer!
You can find more information about our return and refund policy by clicking here.
Are your supplements regulated for quality?
Yep! Every single batch of supplements undergoes third-party testing for heavy metals, pathogens, ingredient profile, and purity. In addition, my products are produced in a GMP-compliant facility in the United States.
What if I have other questions?
Don’t hesitate to reach out! Please email us at hello@restartmed.com and we will do our best to get back to you within a day or so! You can also call us here: (480) 331-9431.
Questions about our quality standards? Please see this article for more information.
No risk to you
If it doesn’t work, you don’t pay for it
60 day money-back guarantee
Return it within 60 days for a full refund. No questions asked and no hoops to jump through.
Third-party tested, every lot
Gluten free, non-GMO, and made in an NSF-certified GMP facility. See the results
Free domestic shipping
Every US order ships free via USPS Ground Advantage regardless of price, processed within one business day and arriving in 3 to 5 business days.
Essential T2
$41.99 or $37.79 with subscribe and save. 60 servings.
Scientific references
View All References
1. Cimmino, M., et al. (1996). Demonstration of in vivo metabolic effects of 3,5-di-iodothyronine. Journal of Endocrinology. doi:10.1677/joe.0.1490319.
2. Lanni, A., et al. (1998). 3,5-Diiodo-L-thyronine and 3,5,3′-triiodo-L-thyronine both improve the cold tolerance of hypothyroid rats, but possibly via different mechanisms. Pflugers Archiv. doi:10.1007/s004240050650.
3. Cavallo, A., et al. (2011). 3,5-Diiodo-L-thyronine increases FoF1-ATP synthase activity and cardiolipin level in liver mitochondria of hypothyroid rats. Journal of Bioenergetics and Biomembranes.
4. Nishikawa, M., et al. (1983). Serum concentrations of 3,3′-diiodothyronine, 3′,5′-diiodothyronine, and 3,5-diiodothyronine in altered thyroid states. Endocrinologia Japonica.
5. Orozco, A., et al. (2014). 3,5-Diiodothyronine (T2) is on a role. A new hormone in search of recognition. General and Comparative Endocrinology. doi:10.1016/j.ygcen.2014.02.014.
6. Antonelli, A., et al. (2011). 3,5-Diiodo-L-thyronine increases resting metabolic rate and reduces body weight without undesirable side effects. Journal of Biological Regulators and Homeostatic Agents.
7. Lorenzini, L., et al. (2019). Assay of endogenous 3,5-diiodo-L-thyronine (3,5-T2) and 3,3′-diiodo-L-thyronine (3,3′-T2) in human serum: a feasibility study. Frontiers in Endocrinology. doi:10.3389/fendo.2019.00088.
8. Goldberg, I.J., et al. (2012). Thyroid hormone reduces cholesterol via a non-LDL receptor-mediated pathway. Endocrinology. doi:10.1210/en.2012-1572.
9. Hernandez, A. (2015). 3,5-Diiodo-L-thyronine (T2) in dietary supplements: what are the physiological effects?. Endocrinology. doi:10.1210/en.2014-1660.
10. Jonas, W., et al. (2015). 3,5-Diiodo-L-thyronine (3,5-T2) exerts thyromimetic effects on hypothalamus-pituitary-thyroid axis, body composition, and energy metabolism in male diet-induced obese mice. Endocrinology. doi:10.1210/en.2014-1604.
11. Peterson, S.J., et al. (2018). An online survey of hypothyroid patients demonstrates prominent dissatisfaction. Thyroid. doi:10.1089/thy.2017.0681.
Additional information
| Weight | .125 lbs |
|---|---|
| Dimensions | 2.25 × 2.25 × 4.25 in |
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
**Results may vary.
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