I’m a big fan of experimenting with my own health.
In fact, most of the strategies and therapies that I’ve developed have been as a result of testing them on myself and then family members.
Today, I’m going to explore my experience using high-dose probiotics for 10 days straight.
I took 1 trillion CFU of my own probiotics for 10 days straight.
- Improved digestion (secondary goal)
- Better sleep
- Better mood
- Improved tolerance to certain foods (my main goal)
- Temporary increase in gas (first 1-2 days)
Why Take High-Dose Probiotics?
I already have what I would call fairly good gut health and even though my experiment did improve my gut health that wasn’t my main goal for doing it.
So, what was?
I wanted to see if I could improve my tolerance to certain foods.
My gut feeling (see what I did there?) is that the food that we ingest plays the most important role in regulating our mood, energy levels, hormones, and more.
While we all might intuitively understand this, it’s actually more difficult than it sounds to find the ideal diet for each person.
Because each of us is unique in terms of our tolerance to certain foods, our taste preferences, the amount of food that we need, the ratio of macromolecules our body does best on, and so on.
In my experience, both in treating myself, my family, and other patients, I’ve found that you can achieve great results with certain restrictive diets but it comes at a cost.
The cost has to do with the inability to have variance in your diet.
You may feel great, but you’re stuck eating very few types of foods because you know you can tolerate them.
I’ve found this to be true in my own health.
I’ve tried pretty much every diet I write about on this blog ranging from the AIP diet to the ketogenic diet, to strict paleo, to vegan, and variations of all of them.
While I found out what I do best, I also don’t want to constantly limit the types of food that I can have or limit my experience in tasting and enjoying what life has to offer (1).
I don’t feel restricted in my diet, but I also want to push the boundaries to see what kind of things I can uncover.
After all, you never know what is available to you if you don’t push the boundaries!
So anyway, my primary goal here was to be able to introduce new foods and to tolerate foods that I previously wasn’t able to tolerate very well.
The method I used to get there was high-dose probiotics (very high doses).
It actually worked.
My Gut Reset Protocol
I would argue that it’s fairly well known that high doses of probiotics are often better than lower doses (2) (this isn’t always true, of course, but most of the time it is).
You see this idea play out in new pharmaceutical companies that are producing pharmaceutical-grade probiotics.
These probiotics contain anywhere from 300 billion CFU per serving all the way up to 700 billion CFU.
This logic, and due to all of the research I’ve done on the topic, is the reason that I created Gut Bomb 350 billion.
Getting up to these very high doses of probiotics seems to create a “shock” to your intestinal system and my hope is that it can alter the environment in your GI tract for the better.
Originally, these high doses of probiotics (from pharmaceutical companies) were designed to treat conditions such as C. Difficile colitis, but I’ve found that high doses tend to work well for people without diagnosed intestinal issues.
And just to put 1 trillion CFU into context, you can consider that the average probiotic contains somewhere between 5 and 15 billion CFU per serving.
That means taking 1 trillion probiotics each day is approximately 66 to 200x more than most probiotics provide you with.
It’s like getting 5 months’ worth of probiotics in a short 10-day period.
Getting up to 1 Trillion CFU Per Day
How did I get up to 1 trillion CFU per day?
The easiest way for me to get there was to use my own probiotics and double up on my most potent probiotic (Gut Bomb 350 billion).
Gut Bomb contains 350 billion probiotics in each sachet and this route was preferable to taking 20-30+ capsules of other brands of probiotics.
The only downside to using high doses of probiotics is getting them into your body.
I found that mixing them with water/juice/smoothies and an immersion blender to be the best approach.
In addition, because I wanted to consume my probiotics with other supplements, I could also add more volume of supplements into liquids that are sweeter (like smoothies).
The exact supplements and probiotics that I used over this 10-day period:
- Gut Bomb 350 billion – 2 Sachets per day (350 billion per Sachet x2 per day is 700 billion CFU). *Note: I’m no longer carrying Gut Bomb 350 Billion as it has been replaced by my 3-in-1 probiotic Thyro Biotic.
- Ultra Biotic x100 – 3 capsules per day (100 billion CFU per capsule x3 per day is 300 billion CFU). *Note: I’m no longer carrying Ultra Biotic x100 as it has been replaced by my 3-in-1 probiotic Thyro Biotic.
- 5-15 grams of L-glutamine powder (this is the L-glutamine that I used (link to Amazon), I think using a powder is ideal to allow you to get higher doses and to prevent swallowing too many capsules each day).
- 2 scoops per day of anti-oxidant red drink (greens + reds).
I should also note that I kept most of my other routines the same (with the exception of my diet because I found I could actually tolerate more foods!).
Total probiotics (Species and Strains consumed each day):
- ~400 billion CFU of Lactobacillus acidophilus La-14
- ~200 billion CFU of Bifidobacterium lactis Bl-04
- ~200 billion CFU of Bifidobacterium lactis HN019
- ~190 billion CFU of Lactobacillus plantarum Lp-115
- ~150 billion CFU of Bifidobacterium longum Bl-05
- ~30 billion CFU of Lactobacillus rhamnosus HN001
- ~10 billion CFU of Lactobacillus bulgaricus Lb-87
- ~10 billion CFU of Bifidobacterium longum infantis Bi-26
- ~10 billion CFU of Bifidobacterium longum Bl-05
- ~10 billion CFU of Bifidobacterium bifidum bb-06
- ~10 billion CFU of Lactobacillus rhamnosus Lr-32
- ~10 billion CFU of Lactobacillus brevis Lbr-35
- ~10 billion CFU of Lactobacillus gasseri Lg-36
- ~10 billion CFU of Lactobacillus casei Lc-11
- ~10 billion CFU of Lactobacillus salivarius Ls-33
- ~10 billion CFU of Bifidobacterium breve Bb-03
- ~10 billion CFU of Lactococcus lactis Ll-23
- ~10 billion CFU of Streptococcus thermophilus St-21
- ~10 billion CFU of Bifidobacterium bifidum Bb-02
You’ll notice that if you add up all of these numbers it totals more than 1 trillion CFU per day.
The reason for this is the fact that Gut Bomb 350 Billion is formulated with 650 billion CFU at the time of manufacture to guarantee that 350 billion is delivered when you ingest it.
So, realistically, it’s possible that I was consuming more than 1 trillion CFU per day but I averaged it out to around that amount.
Through this 10-day period, I also consumed at least 19 different strains of probiotics with the highest doses of the most well-known and studied strains and subspecies of probiotics.
My current feeling is that, when it comes to probiotics, the more diversity in the species that you are consuming the better (which is why I choose this route).
Dosing and how I took them each day:
- Morning = 350 billion CFU + 10 grams L-glutamine + 2 scoops protein powder in my smoothie (it’s really easy to hide supplements and powders in a smoothie because they are so sweet)
- Lunch = 350 billion CFU + 5 grams L-glutamine + red drink in orange juice (orange juice contains naringenin (3) and helps mask the taste)
- Dinner (right before bed) = 300 billion CFU (3 capsules of Ultra Biotic x100) with water (taking these right before bed seemed to help with sleep)
- Total = 350 billion + 350 billion + 300 billion = 1 trillion CFU per day.
The dosing is probably not as important as just making sure that you get up to 1 trillion CFU each day.
I don’t think it would be a good idea to take all 1 trillion at the same time which is why I spaced them out.
Taking some probiotics right before bed is another strategy I used to help improve digestion and sleep and something I will probably continue with.
Okay, so back to my improvements for a moment.
I found out (somewhat accidentally) that taking these high doses of probiotics helped me to tolerate dairy products quite well.
I’ve never talked about my own personal diet before but I can’t tolerate dairy products or gluten very well at all.
I will occasionally have cheese (like when we have a family pizza night) but I always suffer the consequences of abdominal pain and usually increased abdominal bloating (4) as a result.
I found that while using the probiotics my symptoms when consuming cheese cut down by around 80%.
This was huge for me and once I figured out that it was working I actually started to use it a little bit more.
Even despite the huge increase in cheese (3-4 times in the 10-day period), my stomach was doing great.
Another benefit I found was an increase in appetite.
My wife uses Gut Bomb to curb her appetite, but I’m actually trying to gain weight (muscle mass).
While using these high doses of probiotics I found that my appetite had increased and I was consuming larger amounts of healthier foods.
The short 10-day period is too small to determine if this will help me increase my weight or not, but it’s worth mentioning.
In addition to all of these, I also experienced an improvement in my mood (pretty good at baseline but it made me even happier), better sleep (which is something I’m always trying to improve), and better digestion (fairly good to begin with).
The benefits are definitely enough to get me interested and to experiment again in the future (I’m not even convinced that I’m the ideal candidate for this type of cleanse).
Considering Cost (& Will I do it again?)
Obviously, this isn’t a cheap experiment.
The total cost required to do this experiment is the cost of 2 Gut Bombs ($97.50 each) and 1 Ultra Biotic x100 ($69.25) bringing the total to around $264.25 for this 10-day reset.
It’s easy for me to do this because I have a near-unlimited supply of probiotics to choose from!
While it’s not inexpensive I definitely think that it was worth it and I certainly plan to do it again by myself.
I’m also going to experiment on some family members (and some of you if you’re up for it) to see what kind of results I can get.
I’m going to see how long the changes I’ve experimented with will last and then go from there.
I’m thinking that perhaps another 10-day gut cleanse will be in order in about 2-3 months or so.
The only change I would make in future iterations of this 10-day gut cleanse is to have a specific set of foods to eat while doing it and add in some other supplements (especially prebiotics).
In addition, I think a minimal amount of fasting would also probably be beneficial.
I think rounding out the 10-day cleanse with these additions would make the results even more positive.
Should you do it?
I can’t answer for you, nor would I make a recommendation about your health on this medium, but I can say that I definitely enjoyed doing it and will be doing it again.
I plan to run some of my family members through it, especially my wife who is currently breastfeeding.
I want her to re-vamp her GI tract while she is breastfeeding to give the baby a good foundation to stand upon (although I think he is doing great as is).
I have a feeling that this type of protocol will be ideal for those suffering from GI-related conditions such as IBS, constipation, acid reflux, and so on.
I also believe it would be ideal for those with autoimmune conditions (Hashimoto’s, etc.) and those who are looking for weight loss.
On the topic of weight loss, I think experimenting with high-dose probiotics, diet, fasting, and other supplements will probably result in both improved fat loss with improved muscle building.
I would probably not recommend this protocol to those suffering from SIBO (at least not until they go through a bacterial elimination phase).
If you enjoyed reading about my experiment then you’ll probably enjoy some of my future experiments.
Future experiments I have planned:
- 30-day muscle-building experiment with vegan protein powder (will include workout routine, diet, and other supplements)
- 30-day adrenal reset protocol (will include supplements, and other stress reduction techniques)
- 10-14 day Gut cleanse with improvements to see if I can re-introduce gluten back into my diet in small amounts
Most of the time I don’t write about these experiments but I figured it would be a good idea to get some feedback on what types of problems you are facing so that I can find experiments designed to help you.
My goal with my experiments is to find therapies and protocols that can be replicated and that provide results to you.
This is the exact same way I came up with the therapies listed in my weight loss guide (I actually tried them on myself and about 5-10 others at the same time and found we all had amazing results).
It seems that using high-dose probiotics has a potential benefit in improving the GI tract and improving my tolerance to certain foods.
I’m particularly interested in helping people expand their diet and the foods that they have available to them which is why I wanted to share this experiment.
I think that by addressing the gut we can go a long way to improving our health, mood, hormones, and more.
Now I want to hear from you:
Have you experimented with high-dose probiotics before?
What kind of side effects did you experience?
Do you feel it helped you?
Why or why not?
Leave your comments or questions below!