Leptin Resistance Rx - Leptin Sensitizer with ORALVISC & GAGs

Leptin Resistance Rx – Leptin Sensitizer with ORALVISC & GAGs for Metabolic Support


  • Helps lower serum leptin levels*.
  • Helps lower inflammation and inflammatory cytokines*.
  • Both animal studies and human studies suggest ORALVISC helps lower serum leptin levels*.
  • Designed to be used as part of a comprehensive weight loss program.

Earn up to 350 Points.


Leptin Resistance Rx – Targeting Fat Cells & Leptin Resistance

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Leptin Resistance Rx is an over the counter supplement which contains a blend of special glycosaminoglycans (GAGs for short) combined with Vitamin C which help target serum leptin levels and inflammatory levels.

The result?

It is one of the very few supplements which have been shown in clinical trials in both humans and animals to help lower serum leptin levels and manage weight.

One Human Trial showed that taking ORALVISC (blend of GAGs found in Leptin Resistance Rx) daily for 12 weeks resulted in reduced serum leptin levels, inflammatory markers, and cytokines.

I find leptin resistance to be one of the most important underlying hormone imbalances in people who are overweight, especially those with thyroid problems and sex hormone imbalances.

Leptin Resistance Rx is designed to be used as part of a comprehensive weight loss program to help boost your metabolism and assist with weight loss.

How it Works

Leptin resistance is prevalent in all obese patients who have an elevated leptin level but who are unable to lose weight.

This combination is sufficient for the diagnosis of leptin resistance.

What you may not realize is that leptin is probably the single most important factor when determining how likely you are to lose weight and keep it off.

The higher your leptin level, the more leptin resistance present in your body, the less likely you are to lose weight.

This is well known and non-controversial.

While we know that this is the case, there haven’t been many great treatments available to patients with this condition.

Leptin Resistance Rx may help fight leptin resistance by helping to lower serum leptin levels (thereby sensitizing your body to leptin), by helping to reduce inflammation (thereby indirectly improving thyroid function), and improving fat cell turnover by influencing genetic markers on fat cells.

How to Use Leptin Resistance Rx – Treating Leptin Resistance

If you have leptin resistance then you know that it is a difficult condition to treat.

I want to be very clear that while this supplement may help lower your leptin levels and improve leptin resistance it should never be used alone for weight loss.

Instead, it should ALWAYS be used as part of a comprehensive weight loss plan that includes both changes to your diet, exercise, and intermittent fasting.

If used in this way then you will see the best results! Leptin Resistance Rx will help lower your leptin levels which makes your body more susceptible to weight loss but it may not directly lead to weight loss unless it is also combined with other therapies.

How to use Leptin Resistance Rx:

  • For light leptin resistance (serum leptin level between 11-19 ng/ml) -> Use 1 capsule per day and combine with Omega Soothe SR x 3 months in combination with exercise/diet/intermittent fasting.
  • For moderate leptin resistance (serum leptin level between 20-29 ng/ml) -> Use 1 capsule per day and combine with Omega Soothe SR + Gut Bomb 350 Billion x 4-6 months in combination with exercise/diet/intermittent fasting.
  • For extreme leptin resistance (serum leptin level 30+ ng/ml) -> Use 1 capsule per day and combine with Omega Soothe SR + Gut Bomb 350 Billion + Functional Fuel ENERGIZE + prescription medications for leptin resistance in combination with exercise/diet/intermittent fasting.

Leptin Resistance Rx should be used for 1-2 months AFTER you hit your target weight loss goal and during your weight loss phase. This will help you get the best results possible and help you keep your weight off.

Can Leptin Resistance Rx still be used if you aren’t exercising or changing your diet?

The answer is yes, and it will still help sensitize your body to leptin, but you should not expect weight loss during this time if you are not also doing other therapies.

Currently, I find that the combination of high dose probiotics, Leptin resistance Rx, and high doses of fish oil can be helpful in treating leptin resistance (see my recommendations above).

Leptin Resistance Rx can also be used after extreme diets such as the hCG diet to help balance leptin. It is not a cure for the damage done during these diets, but it has the potential to help.

Frequently Asked Questions

Unfortunately, we are not able to ship Leptin Resistance Rx to those who reside in Canada. ORALVISC, the active ingredient, is considered a pharmaceutical in Canada which means we can’t ship it across the border. We are still able to ship ORALVISC to every state in the United States, however.

The formula did NOT change and Leptin Resistance Rx is still the exact same as it was previously.

We recently changed the capsule from a red capsule to a clear capsule for 2 main reasons:

#1. Due to shortages, the red capsule was not readily available which would have put Leptin Resistance Rx on backorder for quite some time.

#2. We used this opportunity to cut down on any unnecessary fillers/dyes. Even though the old red capsule contained natural colorings, there were a small handful of people who reacted to it. Now, these people can take advantage of the new capsule and there are fewer ingredients to worry about.

Other than the color of the capsule, the ingredients are 100% the exact same.

If you are struggling with weight gain, the inability to lose weight, or just want help losing a couple of extra pounds then this supplement is ideal for you.

Almost every single overweight person has some degree of leptin resistance and when present, leptin resistance limits your ability to lose weight and keep it off.

By improving your leptin level you will help your body lose weight faster and keep it off longer.

You do NOT have to check your leptin level prior to using this supplement. Just being overweight is enough to know that you have some degree of leptin resistance.

Checking your level can help you determine how severe your leptin resistance is and can be useful, however.

Take 1 capsule per day, with or without food, for 2-6 months (depending on the severity of your leptin resistance).

The more severe your leptin resistance or the more weight that you want to lose you should take Leptin Resistance Rx for longer.

I recommend continuing taking Leptin Resistance Rx after you get to your target weight for at least 1-2 months to ensure that your weight will stay off.

For more severe forms of leptin resistance, you should also consider adding additional supplements (guidelines above).

Yes! Leptin Resistance Rx can be used with my other supplements (and, in fact, work better this way) and it can be used with all types of thyroid medications.

The duration of therapy depends on how quickly you lose weight and how severe your leptin resistance is.

In general, it’s a good idea to use Leptin Resistance Rx throughout the duration of your weight loss phase and at least 1-2 months into your maintenance phase.

As long as you are trying to lose weight you should be taking it!

You should not experience negative side effects while using Leptin Resistance Rx.

Nope! This product does NOT contain Wheat, gluten, yeast, soy, dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, or artificial preservatives.

All product orders to the United States receive free shipping. We ship out within 1 day of your order (unless you order on the weekend) and it takes approximately 1-3 days to reach the destination depending on how far you live away from Arizona.

We offer international shipping as well! You can calculate the price of shipping at the checkout page (we do not mark up the cost of shipping) and currently we ship to all countries.

All of my products come with a 60-day money-back guarantee. I’m confident that my products will work for you but, in case they don’t, for whatever reason, you can return them for a full refund within 60 days. It makes purchasing them a no-brainer!

You can find more information about our return and refund policy by clicking here.

Yep! Every single batch of supplements undergoes third-party testing for heavy metals, pathogens, ingredient profile, and purity. In addition, my products are produced in a GMP-compliant facility in the United States.

Don’t hesitate to reach out! Please email us at hello@restartmed.com and we will do our best to get back to you within a day or so! You can also call us here: (480) 331-9431.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

**Results may vary.

Questions about our quality standards? Please see this article for more information.

Scientific References

  • https://pubmed.ncbi.nlm.nih.gov/24899570/
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564147/

Additional information

Weight 0.25 lbs
Dimensions 2.5 × 2.5 × 5.0 in

30 Capsules, 60 Capsules

Customer Reviews

Based on 608 reviews
1 bottle isn't showing me anything yet

I can't give a honest review until I have tried this for atleast 3 months.

We have a 60 day guarantee on all of our products. You should be seeing results within 4-6 weeks of consistent use. If you are not seeing the results you had hoped for, we are willing to exchange for another product or refund your investment within the 60 day window. Just let us know how you would like to proceed. You can reach out at hello@restartmed.com


Leptin Resistance Rx - Leptin Sensitizer with ORALVISC & GAGs for Metabolic Support

Mary R.
Gut Bomb / Leptin sensitizer

I take it 4 weeks and I have less hunger. Its really helpful.

Margaret S.
Weight Loss Supplements and Program

I have been taking your weight loss supplements and use your weight loss program. Unfortunately, I did not lose any weight. In fact, I gained few more pounds. I do not know what to do next, as I truly put a lot of effort to lose weight.

Hi Margaret,

Thanks for reaching out and sorry to hear about your struggle! Have you been doing everything listed in the guide including fasting, changing your diet, the use of thyroid medications, the use of hormones, and the use of other prescription medications like GLP-1 agonists? To date, we've only had 2 people who have not lost weight using all of those therapies listed in the guide.

There are many situations in which just using supplements and diet are not enough so if you have only been trying those options then you are probably someone who needs to be more aggressive. For various reasons, some people are just resistant to losing weight either because they have genetic factors at play or because they have severely damaged their metabolism over the course of years and years. In cases such as these, you will often need more than just supplements and diet but the weight loss guide you mentioned provides all of the information on the other therapies that you will need to lose weight.

If you need help with this feel free to reach out to just at hello@restartmed.com or by responding to this email and we can help further!

Donna B.
Less Hunger with Leptin Resistance

My medication I found has made my appetite increase. I started noticing a decrease in appetite after week one of taking the Leptin Resistance. It is great not to be nauseatingly hungry all the time. Great Product and I will be purchasing more.

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Leptin Resistance Rx – Leptin Sensitizer with ORALVISC & GAGs for Metabolic Support
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